Induction and Repair of DNA Double-Strand Breaks in the Same Dose Range as the Shoulder of the Survival Curve

We have used pulsed-field gel electrophoresis (PFGE) to test two hypotheses that have been proposed to explain the survival curves with shoulders which are characteristic of low-LET ionizing radiation: (1) Neutral elution studies of the induction of double-strand breaks (DSBs) have suggested that io...

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Veröffentlicht in:	Radiation Research 1994-11, Vol.140 (2), p.161-165
Hauptverfasser:	Nevaldine, Barbara, Longo, John A., Vilenchik, Michael, King, Gerald A., Hahn, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	BIOCHEMICAL REACTION KINETICS Biological and medical sciences BIOLOGY AND MEDICINE, APPLIED STUDIES BIOLOGY AND MEDICINE, BASIC STUDIES Cell cycle Cell lines Cell Survival - radiation effects Cells, Cultured DNA Damage DNA REPAIR Dose-Response Relationship, Radiation DOSE-RESPONSE RELATIONSHIPS ELECTROPHORESIS Elution Fundamental and applied biological sciences. Psychology Gels Kinetics Lesions LET LOW DOSE IRRADIATION Molecular and cellular biology Molecular genetics Mutagenesis. Repair Radiation dosage RADIOINDUCTION Radiotherapy STRAND BREAKS SURVIVAL CURVES
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