Reduction of Short-Term Radiation Lethality by Biological Response Modifiers Given Alone or in Association with Other Chemical Protectors
The advantages gained by a combined treatment of different chemical protectors on short-term lethality of X-irradiated adult male mice have been studied. The following compounds were given alone or in a mixture of two or three compounds: 16,16-dimethyl PGE2 ( PGE2), cysteine (Cys), glucan, glutathio...
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| Veröffentlicht in: | Radiation research 1993-09, Vol.135 (3), p.332-337 |
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| creator | Maisin, J. R. Albert, C. Henry, A. |
| description | The advantages gained by a combined treatment of different chemical protectors on short-term lethality of X-irradiated adult male mice have been studied. The following compounds were given alone or in a mixture of two or three compounds: 16,16-dimethyl PGE2 ( PGE2), cysteine (Cys), glucan, glutathione (GSH), 5-hydroxytryptamine (5-HT), mercaptoproprionylglycine (MPG), or WR-2721. The survival of mice treated before X irradiation with the optimal dose of each radioprotector given separately shows that WR-2721 and 5-HT yield the best protection with dose reduction factors (DRFs) of 2.2 and 1.7, respectively. Cysteine, glucan, PGE2, MPG, and GSH, with DRFs of 1.4, 1.4, 1.2, 1.1, and 1.1, respectively, are less efficient radioprotectors. When PGE2 was combined with a low dose of WR-2721 (200 mg/kg), the protection increased in a synergistic way. The increase in protection offered by a combination of PGE2 with Cys, glucan, GSH, or 5-HT is less marked and the effect obtained is only additive. A synergistic action is also obtained with a combination of WR-2721 (200 mg/kg) and 5-HT (8 mg/kg) (DRF 2.7). |
| doi_str_mv | 10.2307/3578872 |
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R. ; Albert, C. ; Henry, A.</creator><creatorcontrib>Maisin, J. R. ; Albert, C. ; Henry, A.</creatorcontrib><description>The advantages gained by a combined treatment of different chemical protectors on short-term lethality of X-irradiated adult male mice have been studied. The following compounds were given alone or in a mixture of two or three compounds: 16,16-dimethyl PGE2 ( PGE2), cysteine (Cys), glucan, glutathione (GSH), 5-hydroxytryptamine (5-HT), mercaptoproprionylglycine (MPG), or WR-2721. The survival of mice treated before X irradiation with the optimal dose of each radioprotector given separately shows that WR-2721 and 5-HT yield the best protection with dose reduction factors (DRFs) of 2.2 and 1.7, respectively. Cysteine, glucan, PGE2, MPG, and GSH, with DRFs of 1.4, 1.4, 1.2, 1.1, and 1.1, respectively, are less efficient radioprotectors. When PGE2 was combined with a low dose of WR-2721 (200 mg/kg), the protection increased in a synergistic way. The increase in protection offered by a combination of PGE2 with Cys, glucan, GSH, or 5-HT is less marked and the effect obtained is only additive. A synergistic action is also obtained with a combination of WR-2721 (200 mg/kg) and 5-HT (8 mg/kg) (DRF 2.7).</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3578872</identifier><identifier>PMID: 8397428</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Academic Press, Inc</publisher><subject>16,16-Dimethylprostaglandin E2 - therapeutic use ; Amifostine - therapeutic use ; Animals ; Biological and medical sciences ; Biological effects of radiation ; Cysteine - therapeutic use ; Dosage ; Drug Therapy, Combination ; Endotoxins ; Fundamental and applied biological sciences. Psychology ; Glucans ; Glucans - therapeutic use ; Immunologic Factors - therapeutic use ; Irradiation ; Male ; Mice ; Mice, Inbred Strains ; Mortality ; Protectors ; Radiation dosage ; Radiation Injuries, Experimental - mortality ; Radiation Injuries, Experimental - prevention & control ; Radioprotection ; Serotonin - therapeutic use ; Serotonin receptors ; Solar X rays ; Tissues, organs and organisms biophysics</subject><ispartof>Radiation research, 1993-09, Vol.135 (3), p.332-337</ispartof><rights>Copyright 1993 Academic Press, Inc.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-d218838aeb96ac40c581aa7b54c9227be8817059973479431768cdc02e33d71b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3578872$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3578872$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4175718$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8397428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maisin, J. R.</creatorcontrib><creatorcontrib>Albert, C.</creatorcontrib><creatorcontrib>Henry, A.</creatorcontrib><title>Reduction of Short-Term Radiation Lethality by Biological Response Modifiers Given Alone or in Association with Other Chemical Protectors</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>The advantages gained by a combined treatment of different chemical protectors on short-term lethality of X-irradiated adult male mice have been studied. The following compounds were given alone or in a mixture of two or three compounds: 16,16-dimethyl PGE2 ( PGE2), cysteine (Cys), glucan, glutathione (GSH), 5-hydroxytryptamine (5-HT), mercaptoproprionylglycine (MPG), or WR-2721. The survival of mice treated before X irradiation with the optimal dose of each radioprotector given separately shows that WR-2721 and 5-HT yield the best protection with dose reduction factors (DRFs) of 2.2 and 1.7, respectively. Cysteine, glucan, PGE2, MPG, and GSH, with DRFs of 1.4, 1.4, 1.2, 1.1, and 1.1, respectively, are less efficient radioprotectors. When PGE2 was combined with a low dose of WR-2721 (200 mg/kg), the protection increased in a synergistic way. The increase in protection offered by a combination of PGE2 with Cys, glucan, GSH, or 5-HT is less marked and the effect obtained is only additive. A synergistic action is also obtained with a combination of WR-2721 (200 mg/kg) and 5-HT (8 mg/kg) (DRF 2.7).</description><subject>16,16-Dimethylprostaglandin E2 - therapeutic use</subject><subject>Amifostine - therapeutic use</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological effects of radiation</subject><subject>Cysteine - therapeutic use</subject><subject>Dosage</subject><subject>Drug Therapy, Combination</subject><subject>Endotoxins</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucans</subject><subject>Glucans - therapeutic use</subject><subject>Immunologic Factors - therapeutic use</subject><subject>Irradiation</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Mortality</subject><subject>Protectors</subject><subject>Radiation dosage</subject><subject>Radiation Injuries, Experimental - mortality</subject><subject>Radiation Injuries, Experimental - prevention & control</subject><subject>Radioprotection</subject><subject>Serotonin - therapeutic use</subject><subject>Serotonin receptors</subject><subject>Solar X rays</subject><subject>Tissues, organs and organisms biophysics</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kN9KwzAUxoMoc07xCYRcCF5VkyZd0ss5dAqTyZzXJU1PbUbXjCRT9gi-tXUrwxuvzr8f3-H7ELqk5DZmRNyxREgp4iPUpymTUcIJP0Z9QhiLRCLFKTrzfknamQ7THupJlgoeyz76nkOx0cHYBtsSv1XWhWgBboXnqjBqt59CqFRtwhbnW3xvbG0_jFY1noNf28YDfrGFKQ04jyfmExo8qm0D2Dps2t57qzuhLxMqPAsVODyuYLUTeXU2gA7W-XN0Uqraw0VXB-j98WExfoqms8nzeDSNNGM8REVMpWRSQZ4OleZEJ5IqJfKE6zSORQ5SUkGSNBWMi5QzKoZSF5rEwFghaM4G6Gavq5313kGZrZ1ZKbfNKMl-s8y6LFvyak-uN_kKigPXhdfer7u78q2X0qlGG3_AOBWJoH-wpW99_vvtB9UwhyI</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>Maisin, J. R.</creator><creator>Albert, C.</creator><creator>Henry, A.</creator><general>Academic Press, Inc</general><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19930901</creationdate><title>Reduction of Short-Term Radiation Lethality by Biological Response Modifiers Given Alone or in Association with Other Chemical Protectors</title><author>Maisin, J. R. ; Albert, C. ; Henry, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-d218838aeb96ac40c581aa7b54c9227be8817059973479431768cdc02e33d71b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>16,16-Dimethylprostaglandin E2 - therapeutic use</topic><topic>Amifostine - therapeutic use</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological effects of radiation</topic><topic>Cysteine - therapeutic use</topic><topic>Dosage</topic><topic>Drug Therapy, Combination</topic><topic>Endotoxins</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucans</topic><topic>Glucans - therapeutic use</topic><topic>Immunologic Factors - therapeutic use</topic><topic>Irradiation</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Mortality</topic><topic>Protectors</topic><topic>Radiation dosage</topic><topic>Radiation Injuries, Experimental - mortality</topic><topic>Radiation Injuries, Experimental - prevention & control</topic><topic>Radioprotection</topic><topic>Serotonin - therapeutic use</topic><topic>Serotonin receptors</topic><topic>Solar X rays</topic><topic>Tissues, organs and organisms biophysics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maisin, J. R.</creatorcontrib><creatorcontrib>Albert, C.</creatorcontrib><creatorcontrib>Henry, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maisin, J. R.</au><au>Albert, C.</au><au>Henry, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduction of Short-Term Radiation Lethality by Biological Response Modifiers Given Alone or in Association with Other Chemical Protectors</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>1993-09-01</date><risdate>1993</risdate><volume>135</volume><issue>3</issue><spage>332</spage><epage>337</epage><pages>332-337</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>The advantages gained by a combined treatment of different chemical protectors on short-term lethality of X-irradiated adult male mice have been studied. The following compounds were given alone or in a mixture of two or three compounds: 16,16-dimethyl PGE2 ( PGE2), cysteine (Cys), glucan, glutathione (GSH), 5-hydroxytryptamine (5-HT), mercaptoproprionylglycine (MPG), or WR-2721. The survival of mice treated before X irradiation with the optimal dose of each radioprotector given separately shows that WR-2721 and 5-HT yield the best protection with dose reduction factors (DRFs) of 2.2 and 1.7, respectively. Cysteine, glucan, PGE2, MPG, and GSH, with DRFs of 1.4, 1.4, 1.2, 1.1, and 1.1, respectively, are less efficient radioprotectors. When PGE2 was combined with a low dose of WR-2721 (200 mg/kg), the protection increased in a synergistic way. The increase in protection offered by a combination of PGE2 with Cys, glucan, GSH, or 5-HT is less marked and the effect obtained is only additive. A synergistic action is also obtained with a combination of WR-2721 (200 mg/kg) and 5-HT (8 mg/kg) (DRF 2.7).</abstract><cop>Oak Brook, Il</cop><pub>Academic Press, Inc</pub><pmid>8397428</pmid><doi>10.2307/3578872</doi><tpages>6</tpages></addata></record> |
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| subjects | 16,16-Dimethylprostaglandin E2 - therapeutic use Amifostine - therapeutic use Animals Biological and medical sciences Biological effects of radiation Cysteine - therapeutic use Dosage Drug Therapy, Combination Endotoxins Fundamental and applied biological sciences. Psychology Glucans Glucans - therapeutic use Immunologic Factors - therapeutic use Irradiation Male Mice Mice, Inbred Strains Mortality Protectors Radiation dosage Radiation Injuries, Experimental - mortality Radiation Injuries, Experimental - prevention & control Radioprotection Serotonin - therapeutic use Serotonin receptors Solar X rays Tissues, organs and organisms biophysics |
| title | Reduction of Short-Term Radiation Lethality by Biological Response Modifiers Given Alone or in Association with Other Chemical Protectors |
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