Influence of Melanin on Mutation Load in Drosophila Populations after Long-Term Irradiation
The effect of melanin on the level of mutation load has been studied in experimental Drosophila populations exposed to radiation for 115 generations. Four types of populations have been analyzed: (1) control; (2) treated with melanin; (3) irradiated; (4) irradiated and treated with melanin. Melanin...
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| Veröffentlicht in: | Radiation Research 1994-09, Vol.139 (3), p.357-359 |
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| creator | Mosse, I. B. Lyakh, I. P. |
| description | The effect of melanin on the level of mutation load has been studied in experimental Drosophila populations exposed to radiation for 115 generations. Four types of populations have been analyzed: (1) control; (2) treated with melanin; (3) irradiated; (4) irradiated and treated with melanin. Melanin was produced by auto-oxidation of 1-dioxyphenylalanine and was constantly added to food. Populations were X-irradiated twice in each generation (at the larvae stage with 6 Gy and at the imago stage with 9 Gy). The level of recessive mutation on the third chromosome was analyzed by a standard genetic method of balanced lethals. The data obtained have shown that the populations exposed to long-term irradiation have the greatest number of mutations decreasing viability. Melanin exhibited radioprotective properties-it reduced the percentage of lethal, semilethal and subvital mutations. Thus the possibility of effective protection of populations exposed to radiation for many generations by melanin has been shown for the first time. |
| doi_str_mv | 10.2307/3578834 |
| format | Article |
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B.</creatorcontrib><creatorcontrib>Lyakh, I. P.</creatorcontrib><title>Influence of Melanin on Mutation Load in Drosophila Populations after Long-Term Irradiation</title><title>Radiation Research</title><addtitle>Radiat Res</addtitle><description>The effect of melanin on the level of mutation load has been studied in experimental Drosophila populations exposed to radiation for 115 generations. Four types of populations have been analyzed: (1) control; (2) treated with melanin; (3) irradiated; (4) irradiated and treated with melanin. Melanin was produced by auto-oxidation of 1-dioxyphenylalanine and was constantly added to food. Populations were X-irradiated twice in each generation (at the larvae stage with 6 Gy and at the imago stage with 9 Gy). The level of recessive mutation on the third chromosome was analyzed by a standard genetic method of balanced lethals. The data obtained have shown that the populations exposed to long-term irradiation have the greatest number of mutations decreasing viability. Melanin exhibited radioprotective properties-it reduced the percentage of lethal, semilethal and subvital mutations. Thus the possibility of effective protection of populations exposed to radiation for many generations by melanin has been shown for the first time.</description><subject>Animals</subject><subject>BIOLOGY AND MEDICINE, APPLIED STUDIES</subject><subject>BIOLOGY AND MEDICINE, BASIC STUDIES</subject><subject>Chromosomes</subject><subject>DROSOPHILA</subject><subject>Drosophila melanogaster</subject><subject>Female</subject><subject>Free radicals</subject><subject>Genetic mutation</subject><subject>GENETIC RADIATION EFFECTS</subject><subject>Irradiation</subject><subject>Male</subject><subject>MELANIN</subject><subject>Melanins - physiology</subject><subject>Mutagenesis - radiation effects</subject><subject>MUTATION FREQUENCY</subject><subject>Population genetics</subject><subject>Radiation damage</subject><subject>Radiation genetics</subject><subject>Radiation protection</subject><subject>Radiation-Protective Agents</subject><subject>RADIOSENSITIVITY</subject><subject>RESPONSE MODIFYING FACTORS</subject><subject>Short Communications</subject><subject>VIABILITY</subject><subject>X RADIATION</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAUhS0EKqUgfgGSBySmgJ3rxPGIeFZqBUOZGCLHD5oqtSM7Gfj3mLZiY7qP8-lI5yB0ScltDoTfQcGrCtgRmlIBVVYwwo7RlBCAjBcVP0VnMW5IumkpJmhSEQ6Uiin6nDvbjcYpg73FS9NJ1zrsHV6OgxzatCy81Dj9HoOPvl-3ncTvvh-7nRqxtIMJCXJf2cqELZ6HIHW7E8_RiZVdNBeHOUMfz0-rh9ds8fYyf7hfZAqADJkucqMK2TSqEkABgJUgFUgmSlkYrmxpQQhuTGWp1lwL0jBuBM-1YNSmIDOE974-Dm0dVTsYtVbeOaOGmpM8Zwm52SMqpYjB2LoP7VaG75qS-rfA-lBgIq_2ZD82W6P_uENjSb_e65s4-PCvzQ_1lXW2</recordid><startdate>19940901</startdate><enddate>19940901</enddate><creator>Mosse, I. B.</creator><creator>Lyakh, I. P.</creator><general>Radiation Research Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19940901</creationdate><title>Influence of Melanin on Mutation Load in Drosophila Populations after Long-Term Irradiation</title><author>Mosse, I. B. ; Lyakh, I. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-d52ec5abbc8931333463ac3a496a5e7cf6f3997ee8f1dd7d90b47e972d941f073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>BIOLOGY AND MEDICINE, APPLIED STUDIES</topic><topic>BIOLOGY AND MEDICINE, BASIC STUDIES</topic><topic>Chromosomes</topic><topic>DROSOPHILA</topic><topic>Drosophila melanogaster</topic><topic>Female</topic><topic>Free radicals</topic><topic>Genetic mutation</topic><topic>GENETIC RADIATION EFFECTS</topic><topic>Irradiation</topic><topic>Male</topic><topic>MELANIN</topic><topic>Melanins - physiology</topic><topic>Mutagenesis - radiation effects</topic><topic>MUTATION FREQUENCY</topic><topic>Population genetics</topic><topic>Radiation damage</topic><topic>Radiation genetics</topic><topic>Radiation protection</topic><topic>Radiation-Protective Agents</topic><topic>RADIOSENSITIVITY</topic><topic>RESPONSE MODIFYING FACTORS</topic><topic>Short Communications</topic><topic>VIABILITY</topic><topic>X RADIATION</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mosse, I. B.</creatorcontrib><creatorcontrib>Lyakh, I. P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Radiation Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mosse, I. B.</au><au>Lyakh, I. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Melanin on Mutation Load in Drosophila Populations after Long-Term Irradiation</atitle><jtitle>Radiation Research</jtitle><addtitle>Radiat Res</addtitle><date>1994-09-01</date><risdate>1994</risdate><volume>139</volume><issue>3</issue><spage>357</spage><epage>359</epage><pages>357-359</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>The effect of melanin on the level of mutation load has been studied in experimental Drosophila populations exposed to radiation for 115 generations. Four types of populations have been analyzed: (1) control; (2) treated with melanin; (3) irradiated; (4) irradiated and treated with melanin. Melanin was produced by auto-oxidation of 1-dioxyphenylalanine and was constantly added to food. Populations were X-irradiated twice in each generation (at the larvae stage with 6 Gy and at the imago stage with 9 Gy). The level of recessive mutation on the third chromosome was analyzed by a standard genetic method of balanced lethals. The data obtained have shown that the populations exposed to long-term irradiation have the greatest number of mutations decreasing viability. Melanin exhibited radioprotective properties-it reduced the percentage of lethal, semilethal and subvital mutations. Thus the possibility of effective protection of populations exposed to radiation for many generations by melanin has been shown for the first time.</abstract><cop>United States</cop><pub>Radiation Research Society</pub><pmid>8073119</pmid><doi>10.2307/3578834</doi><tpages>3</tpages></addata></record> |
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| ispartof | Radiation Research, 1994-09, Vol.139 (3), p.357-359 |
| issn | 0033-7587 1938-5404 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Animals BIOLOGY AND MEDICINE, APPLIED STUDIES BIOLOGY AND MEDICINE, BASIC STUDIES Chromosomes DROSOPHILA Drosophila melanogaster Female Free radicals Genetic mutation GENETIC RADIATION EFFECTS Irradiation Male MELANIN Melanins - physiology Mutagenesis - radiation effects MUTATION FREQUENCY Population genetics Radiation damage Radiation genetics Radiation protection Radiation-Protective Agents RADIOSENSITIVITY RESPONSE MODIFYING FACTORS Short Communications VIABILITY X RADIATION |
| title | Influence of Melanin on Mutation Load in Drosophila Populations after Long-Term Irradiation |
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