Radiorecovery activity of manganese(III)2(II)(μ3-O)-(μ-3,5-diisopropylsalicylate)6
Manganese(III)2(II)(mu 3-O)(mu-3,5-diisopropylsalicylate)6 [Mn3(O)(3,5-DIPS)6] was used to treat female C57BL/6 mice irradiated with LD50/30 doses of gamma rays and examine the possibility that treatment after irradiation increases survival. Female C57BL/6 mice were treated with 0, 10, 20, or 40 mum...
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| Veröffentlicht in: | Radiation research 1993-10, Vol.136 (1), p.126-129 |
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| container_title | Radiation research |
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| creator | HENDERSON, T. D BURT, R. L KAUFMAN, S. E WILLINGHAM, W. M SORENSON, J. R. J |
| description | Manganese(III)2(II)(mu 3-O)(mu-3,5-diisopropylsalicylate)6 [Mn3(O)(3,5-DIPS)6] was used to treat female C57BL/6 mice irradiated with LD50/30 doses of gamma rays and examine the possibility that treatment after irradiation increases survival. Female C57BL/6 mice were treated with 0, 10, 20, or 40 mumol Mn3(O)(3,5-DIPS)6/kg of body mass 1 or 3 h after irradiation. Treatment with 40 mumol/kg 1 or 3 h after irradiation produced survivals of 72 or 92%, respectively, increases of 29 or 130% in comparison with 56 or 40% survivals in the respective vehicle-treated groups. These data support the hypothesis that Mn3(O)(3,5-DIPS)6 is an effective radiorecovery agent. |
| doi_str_mv | 10.2307/3578649 |
| format | Article |
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D ; BURT, R. L ; KAUFMAN, S. E ; WILLINGHAM, W. M ; SORENSON, J. R. J</creator><creatorcontrib>HENDERSON, T. D ; BURT, R. L ; KAUFMAN, S. E ; WILLINGHAM, W. M ; SORENSON, J. R. J</creatorcontrib><description>Manganese(III)2(II)(mu 3-O)(mu-3,5-diisopropylsalicylate)6 [Mn3(O)(3,5-DIPS)6] was used to treat female C57BL/6 mice irradiated with LD50/30 doses of gamma rays and examine the possibility that treatment after irradiation increases survival. Female C57BL/6 mice were treated with 0, 10, 20, or 40 mumol Mn3(O)(3,5-DIPS)6/kg of body mass 1 or 3 h after irradiation. Treatment with 40 mumol/kg 1 or 3 h after irradiation produced survivals of 72 or 92%, respectively, increases of 29 or 130% in comparison with 56 or 40% survivals in the respective vehicle-treated groups. These data support the hypothesis that Mn3(O)(3,5-DIPS)6 is an effective radiorecovery agent.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3578649</identifier><identifier>PMID: 8210328</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Radiation Research Society</publisher><subject>Animals ; Biological and medical sciences ; Biological effects of radiation ; Female ; Fundamental and applied biological sciences. Psychology ; Gamma Rays ; Ionizing radiations ; Manganese Compounds - pharmacology ; Mice ; Mice, Inbred C57BL ; Organometallic Compounds - pharmacology ; Radiation Injuries, Experimental - prevention & control ; Radiation-Protective Agents - pharmacology ; Salicylates - pharmacology ; Tissues, organs and organisms biophysics</subject><ispartof>Radiation research, 1993-10, Vol.136 (1), p.126-129</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c220t-fff7ba8194eaefcd79967573339e11f6e69e5dcce4c5c30ef1f866dbf85588d63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3823603$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8210328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HENDERSON, T. D</creatorcontrib><creatorcontrib>BURT, R. L</creatorcontrib><creatorcontrib>KAUFMAN, S. E</creatorcontrib><creatorcontrib>WILLINGHAM, W. M</creatorcontrib><creatorcontrib>SORENSON, J. R. J</creatorcontrib><title>Radiorecovery activity of manganese(III)2(II)(μ3-O)-(μ-3,5-diisopropylsalicylate)6</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>Manganese(III)2(II)(mu 3-O)(mu-3,5-diisopropylsalicylate)6 [Mn3(O)(3,5-DIPS)6] was used to treat female C57BL/6 mice irradiated with LD50/30 doses of gamma rays and examine the possibility that treatment after irradiation increases survival. Female C57BL/6 mice were treated with 0, 10, 20, or 40 mumol Mn3(O)(3,5-DIPS)6/kg of body mass 1 or 3 h after irradiation. Treatment with 40 mumol/kg 1 or 3 h after irradiation produced survivals of 72 or 92%, respectively, increases of 29 or 130% in comparison with 56 or 40% survivals in the respective vehicle-treated groups. These data support the hypothesis that Mn3(O)(3,5-DIPS)6 is an effective radiorecovery agent.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological effects of radiation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gamma Rays</subject><subject>Ionizing radiations</subject><subject>Manganese Compounds - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Radiation Injuries, Experimental - prevention & control</subject><subject>Radiation-Protective Agents - pharmacology</subject><subject>Salicylates - pharmacology</subject><subject>Tissues, organs and organisms biophysics</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kN1KwzAYhoMoc07xCoQdCK5gNOnX_B3K8KcwGMg8LlmaSKRdS1IHvTevwWuysrKT7-XjfXgPHoSuKXlIgYhHYELyTJ2gKVUgMctIdoqmhABgwaQ4RxcxfpHhp1xN0ESmlEAqp2jzrkvfBGuavQ39XJvO733Xzxs3r_XuU-9stIs8z5N0uMni9wfwOsFDYrhnuPQ-Nm1o2r6KuvKmr3RnE36Jzpyuor0ac4Y-Xp43yze8Wr_my6cVNmlKOuycE1stqcqsts6UQikumAAAZSl13HJlWWmMzQwzQKyjTnJebp1kTMqSwwzdHXZNaGIM1hVt8LUOfUFJ8a-lGLUM5M2BbL-3tS2P3Ohh6G_HXkejKxf0zvh4xECmwAeXf9laaTI</recordid><startdate>199310</startdate><enddate>199310</enddate><creator>HENDERSON, T. D</creator><creator>BURT, R. L</creator><creator>KAUFMAN, S. E</creator><creator>WILLINGHAM, W. M</creator><creator>SORENSON, J. R. J</creator><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199310</creationdate><title>Radiorecovery activity of manganese(III)2(II)(μ3-O)-(μ-3,5-diisopropylsalicylate)6</title><author>HENDERSON, T. D ; BURT, R. L ; KAUFMAN, S. E ; WILLINGHAM, W. M ; SORENSON, J. R. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c220t-fff7ba8194eaefcd79967573339e11f6e69e5dcce4c5c30ef1f866dbf85588d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological effects of radiation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gamma Rays</topic><topic>Ionizing radiations</topic><topic>Manganese Compounds - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Organometallic Compounds - pharmacology</topic><topic>Radiation Injuries, Experimental - prevention & control</topic><topic>Radiation-Protective Agents - pharmacology</topic><topic>Salicylates - pharmacology</topic><topic>Tissues, organs and organisms biophysics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HENDERSON, T. D</creatorcontrib><creatorcontrib>BURT, R. L</creatorcontrib><creatorcontrib>KAUFMAN, S. E</creatorcontrib><creatorcontrib>WILLINGHAM, W. M</creatorcontrib><creatorcontrib>SORENSON, J. R. 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J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiorecovery activity of manganese(III)2(II)(μ3-O)-(μ-3,5-diisopropylsalicylate)6</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>1993-10</date><risdate>1993</risdate><volume>136</volume><issue>1</issue><spage>126</spage><epage>129</epage><pages>126-129</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>Manganese(III)2(II)(mu 3-O)(mu-3,5-diisopropylsalicylate)6 [Mn3(O)(3,5-DIPS)6] was used to treat female C57BL/6 mice irradiated with LD50/30 doses of gamma rays and examine the possibility that treatment after irradiation increases survival. Female C57BL/6 mice were treated with 0, 10, 20, or 40 mumol Mn3(O)(3,5-DIPS)6/kg of body mass 1 or 3 h after irradiation. Treatment with 40 mumol/kg 1 or 3 h after irradiation produced survivals of 72 or 92%, respectively, increases of 29 or 130% in comparison with 56 or 40% survivals in the respective vehicle-treated groups. These data support the hypothesis that Mn3(O)(3,5-DIPS)6 is an effective radiorecovery agent.</abstract><cop>Oak Brook, Il</cop><pub>Radiation Research Society</pub><pmid>8210328</pmid><doi>10.2307/3578649</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Radiation research, 1993-10, Vol.136 (1), p.126-129 |
| issn | 0033-7587 1938-5404 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Animals Biological and medical sciences Biological effects of radiation Female Fundamental and applied biological sciences. Psychology Gamma Rays Ionizing radiations Manganese Compounds - pharmacology Mice Mice, Inbred C57BL Organometallic Compounds - pharmacology Radiation Injuries, Experimental - prevention & control Radiation-Protective Agents - pharmacology Salicylates - pharmacology Tissues, organs and organisms biophysics |
| title | Radiorecovery activity of manganese(III)2(II)(μ3-O)-(μ-3,5-diisopropylsalicylate)6 |
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