Hypoxia and Resistance to Hydrogen Peroxide Confer Resistance to Tumor Necrosis Factor in Murine L929 Cells

The mechanism whereby tumor necrosis factor (TNF) kills mammalian cells is not well understood, although oxidative damage has been suggested by several investigators. Further, it is not known why cells vary in their responsiveness to TNF. We show that the cytotoxic effect of TNF toward TNF-sensitive...

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Veröffentlicht in:	Radiation research 1992-08, Vol.131 (2), p.162-168
Hauptverfasser:	Park, Young-Mee K., Anderson, Robin L., Spitz, Douglas R., Hahn, George M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaerobic conditions Animals Biological and medical sciences Cell Line Cell lines Cell physiology Drug Resistance Enzymes Fundamental and applied biological sciences. Psychology Hydrogen Hydrogen Peroxide - pharmacology Hypoxia Mice Molecular and cellular biology Oxygen - physiology Peroxides Receptors Tumor cell line Tumor Necrosis Factor-alpha - toxicity Tumor necrosis factors Tumors
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