50 Hz AC Sinusoidal Electric Fields Do Not Exert Genotoxic Effects (Micronucleus Formation) in Human Lymphocytes
Electromagnetic fields produce a variety of effects in several biological systems, including human peripheral blood lymphocytes. A great concern exists regarding possible carcinogenic effects in subjects exposed environmentally to such fields in the vicinity of power lines and electric domestic appl...
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| Veröffentlicht in: | Radiation research 1993-07, Vol.135 (1), p.64-68 |
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| container_title | Radiation research |
| container_volume | 135 |
| creator | Scarfì, M. R. Bersani, F. Cossarizza, A. Monti, D. Zeni, O. Lioi, M. B. Franceschetti, G. Capri, M. Franceschi, C. |
| description | Electromagnetic fields produce a variety of effects in several biological systems, including human peripheral blood lymphocytes. A great concern exists regarding possible carcinogenic effects in subjects exposed environmentally to such fields in the vicinity of power lines and electric domestic appliances. Using human lymphocytes from 33 healthy donors and a sensitive cytogenetic method, the cytokinesis-block micronucleus assay, we have demonstrated that the exposure to 50-Hz AC sinusoidal electric fields over a wide range of intensities (0.5-10 kV/m in air) does not increase the spontaneous frequency of micronuclei. Moreover, these fields did not affect the mitomycin-C-induced micronucleus formation, suggesting that they did not exert any synergistic or antagonistic effect. |
| doi_str_mv | 10.2307/3578397 |
| format | Article |
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Moreover, these fields did not affect the mitomycin-C-induced micronucleus formation, suggesting that they did not exert any synergistic or antagonistic effect.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3578397</identifier><identifier>PMID: 8327662</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Academic Press, Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blood ; Cells, Cultured ; Cultured cells ; Effects of various physical factors on living matter (vibrations, electric field, ultrasound, sound...) ; Electric fields ; Electromagnetic Fields ; Fundamental and applied biological sciences. Psychology ; Humans ; Incubators ; Lymphocytes ; Lymphocytes - drug effects ; Lymphocytes - radiation effects ; Magnetic fields ; Micronucleus Tests ; Middle Aged ; Mitomycin - toxicity ; Mutation ; Proportions ; Statistical analysis ; T tests ; Tissues, organs and organisms biophysics</subject><ispartof>Radiation research, 1993-07, Vol.135 (1), p.64-68</ispartof><rights>Copyright 1993 Academic Press, Inc.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-370a588f9747d9ef2ef769fb2758d06d2eab15cd84295d389b2230c598f137843</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3578397$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3578397$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3745622$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8327662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scarfì, M. R.</creatorcontrib><creatorcontrib>Bersani, F.</creatorcontrib><creatorcontrib>Cossarizza, A.</creatorcontrib><creatorcontrib>Monti, D.</creatorcontrib><creatorcontrib>Zeni, O.</creatorcontrib><creatorcontrib>Lioi, M. B.</creatorcontrib><creatorcontrib>Franceschetti, G.</creatorcontrib><creatorcontrib>Capri, M.</creatorcontrib><creatorcontrib>Franceschi, C.</creatorcontrib><title>50 Hz AC Sinusoidal Electric Fields Do Not Exert Genotoxic Effects (Micronucleus Formation) in Human Lymphocytes</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>Electromagnetic fields produce a variety of effects in several biological systems, including human peripheral blood lymphocytes. A great concern exists regarding possible carcinogenic effects in subjects exposed environmentally to such fields in the vicinity of power lines and electric domestic appliances. Using human lymphocytes from 33 healthy donors and a sensitive cytogenetic method, the cytokinesis-block micronucleus assay, we have demonstrated that the exposure to 50-Hz AC sinusoidal electric fields over a wide range of intensities (0.5-10 kV/m in air) does not increase the spontaneous frequency of micronuclei. Moreover, these fields did not affect the mitomycin-C-induced micronucleus formation, suggesting that they did not exert any synergistic or antagonistic effect.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Cells, Cultured</subject><subject>Cultured cells</subject><subject>Effects of various physical factors on living matter (vibrations, electric field, ultrasound, sound...)</subject><subject>Electric fields</subject><subject>Electromagnetic Fields</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Incubators</subject><subject>Lymphocytes</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - radiation effects</subject><subject>Magnetic fields</subject><subject>Micronucleus Tests</subject><subject>Middle Aged</subject><subject>Mitomycin - toxicity</subject><subject>Mutation</subject><subject>Proportions</subject><subject>Statistical analysis</subject><subject>T tests</subject><subject>Tissues, organs and organisms biophysics</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9LwzAYh4Moc07xEwg5COqhmiZNkxzH7DZh6kE9lzRNMKNtStLC5qe3siJePL28_B7ePw8AlzG6xwSxB0IZJ4IdgWksCI9ogpJjMEWIkIhRzk7BWQhbNPRxKiZgwglmaYqnoKUIrr_gfAHfbNMHZ0tZwazSqvNWwaXVVRngo4MvroPZTvsOrnTjOrcb0syYgQvw9tkq75peVboPcOl8LTvrmjtoG7jua9nAzb5uP53adzqcgxMjq6AvxjoDH8vsfbGONq-rp8V8EylCki4iDEnKuREsYaXQBmvDUmEKPHxTorTEWhYxVSVPsKAl4aLAgwdFBTcxYTwhM3BzmDucFoLXJm-9raXf5zHKf5Tlo7KBvDqQbV_UuvzlRkdDfj3mMihZGS8bZcMvRlhCU_wH24bO-X-3fQPrAnyR</recordid><startdate>19930701</startdate><enddate>19930701</enddate><creator>Scarfì, M. 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Psychology</topic><topic>Humans</topic><topic>Incubators</topic><topic>Lymphocytes</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - radiation effects</topic><topic>Magnetic fields</topic><topic>Micronucleus Tests</topic><topic>Middle Aged</topic><topic>Mitomycin - toxicity</topic><topic>Mutation</topic><topic>Proportions</topic><topic>Statistical analysis</topic><topic>T tests</topic><topic>Tissues, organs and organisms biophysics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scarfì, M. R.</creatorcontrib><creatorcontrib>Bersani, F.</creatorcontrib><creatorcontrib>Cossarizza, A.</creatorcontrib><creatorcontrib>Monti, D.</creatorcontrib><creatorcontrib>Zeni, O.</creatorcontrib><creatorcontrib>Lioi, M. 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| ispartof | Radiation research, 1993-07, Vol.135 (1), p.64-68 |
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| language | eng |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Adult Aged Biological and medical sciences Blood Cells, Cultured Cultured cells Effects of various physical factors on living matter (vibrations, electric field, ultrasound, sound...) Electric fields Electromagnetic Fields Fundamental and applied biological sciences. Psychology Humans Incubators Lymphocytes Lymphocytes - drug effects Lymphocytes - radiation effects Magnetic fields Micronucleus Tests Middle Aged Mitomycin - toxicity Mutation Proportions Statistical analysis T tests Tissues, organs and organisms biophysics |
| title | 50 Hz AC Sinusoidal Electric Fields Do Not Exert Genotoxic Effects (Micronucleus Formation) in Human Lymphocytes |
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