Variation of Single-Strand Break Yield with Scavenger Concentration for Plasmid DNA Irradiated in Aqueous Solution

We have measured the yield of single-strand breaks (SSBs), induced by 137 Cs γ radiation as assayed by agarose gel electrophoresis, for three plasmids and SV40 DNA irradiated in aerobic aqueous solution. DNA SSBs are caused mainly by the hydroxyl radical under these conditions. To characterize the r...

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Veröffentlicht in:	Radiation research 1993-02, Vol.133 (2), p.151-157
Hauptverfasser:	Milligan, J. R., Aguilera, J. A., Ward, J. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aqueous solutions Biological and medical sciences Biological effects of radiation Cesium Radioisotopes DNA DNA Damage DNA, Single-Stranded - radiation effects DNA, Viral - radiation effects Free Radical Scavengers Fundamental and applied biological sciences. Psychology Gamma Rays Gels Genetic variation Hydroxyl radicals Ionizing radiations Kinetics Plasmids Radiation dosage Radiation Genetics Radius of a sphere Scavenging Simian virus 40 Solutions Tissues, organs and organisms biophysics Water
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