Isolation and Characterization of BHK Cells Sensitive to Ionizing Radiation and Alkylating Agents

A host-cell viral suicide enrichment procedure was used to isolate BHK strains sensitive to ionizing radiation. Of six strains surviving infection with irradiated herpes simplex virus (HSV), three were found to be more sensitive to ionizing radiation than the parental BHK cells. Thus the$D_{0}\text{...

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Veröffentlicht in:	Radiat. Res.; (United States) 1984-07, Vol.99 (1), p.202-210
Hauptverfasser:	Evans, Helen H., Horng, M. F., Weber, M. C., Glazier, K. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	560301 > Chemicals Metabolism & Toxicology-- Cells-- (-1987) Alkylating Agents - pharmacology ANIMAL CELLS Animals Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BIOLOGICAL RECOVERY BIOLOGICAL REPAIR CARBONIC ACID DERIVATIVES Cell cultures. Hybridization. Fusion Cell Line Cell lines Cell Survival - drug effects Cell Survival - radiation effects CHO cells Cricetinae DISEASES Dose-Response Relationship, Drug Drug Tolerance ELECTROMAGNETIC RADIATION EMS ESTERS Ethyl Methanesulfonate - pharmacology Fundamental and applied biological sciences. Psychology Genetic mutation GUANIDINES HeLa cells HERPES SIMPLEX HOST-CELL REACTIVATION IN VITRO INFECTIOUS DISEASES Ionizing radiation IONIZING RADIATIONS Kidney Liver cells METHYL METHANESULFONATE Methyl Methanesulfonate - pharmacology Methylnitronitrosoguanidine - pharmacology MICROORGANISMS Molecular and cellular biology Mutagenesis MUTAGENS MUTATIONS NITROSO COMPOUNDS ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC SULFUR COMPOUNDS PARASITES RADIATION EFFECTS Radiation Tolerance RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RECOVERY REPAIR Simplexvirus SKIN DISEASES SOMATIC CELLS Suicide SULFONIC ACID ESTERS ULTRAVIOLET RADIATION VIRAL DISEASES 560121 > Radiation Effects on Cells-- External Source-- (-1987) VIRUSES X RADIATION
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