Effect of Misonidazole on Formation of Thymine Damage by Gamma Rays

The effect of the radiosensitizer misonidazole (Ro-07-0582) on the formation of thymine base damage of the 5,6-dihydroxydihydrothymine-type by γ rays was measured under aerobic and hypoxic conditions. HeLa cells, prelabeled with [methyl-3 H]thymidine, were suspended in phosphate-buffered saline in t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Radiat. Res.; (United States) 1985-02, Vol.101 (2), p.306-311
1. Verfasser:	Remsen, J. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	560111 - Radiation Effects on Biochemicals- In Vitro- (-1987) Aerobiosis Anaerobic conditions Anaerobiosis ANOXIA ANTINEOPLASTIC DRUGS AZINES AZOLES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL EFFECTS Biological effects of radiation BIOLOGICAL RADIATION EFFECTS COBALT 60 COBALT ISOTOPES Cobalt Radioisotopes DATA DNA DNA damage Dose-Response Relationship, Drug Dose-Response Relationship, Radiation DOSE-RESPONSE RELATIONSHIPS DRUGS ELECTROMAGNETIC RADIATION EXPERIMENTAL DATA Flood damage Frost damage Fundamental and applied biological sciences. Psychology GAMMA RADIATION Gamma Rays HELA CELLS HeLa Cells - drug effects HeLa Cells - radiation effects HETEROCYCLIC COMPOUNDS Humans HYDROXY COMPOUNDS Hydroxyl radicals Hypoxia IMIDAZOLES INFORMATION INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES IONIZING RADIATIONS Irradiation ISOMERIC TRANSITION ISOTOPES ISOTOPES LABELLED COMPOUNDS MINUTES LIVING RADIOISOTOPES MISONIDAZOLE Misonidazole - pharmacology Nitroimidazoles - pharmacology NUCLEI NUCLEIC ACIDS NUMERICAL DATA ODD-ODD NUCLEI ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS Oxygen PYRIMIDINES Radiation damage RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Radiation-Sensitizing Agents - pharmacology RADIATIONS RADIOISOTOPES RADIOSENSITIVITY EFFECTS RADIOSENSITIZERS THYMINE Thymine - radiation effects Tissues, organs and organisms biophysics TRITIUM COMPOUNDS URACILS YEARS LIVING RADIOISOTOPES
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!