Chemical and Biological Consequences of the Radioactive Decay of Iodine-125 in Plasmid DNA
Doubly labeled $[{\rm U}\text{-}{}^{14}{\rm C},\ 5\text{-}{}^{125}{\rm I}]\text{iododeoxycytidine}$ (IdC) triphosphate was synthesized and incorporated enzymatically into defined positions of the plasmid pBR322. After storage under various conditions, the stable end products were analyzed using radi...
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| Veröffentlicht in: | Radiat. Res.; (United States) 1985-02, Vol.101 (2), p.262-278 |
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| description | Doubly labeled $[{\rm U}\text{-}{}^{14}{\rm C},\ 5\text{-}{}^{125}{\rm I}]\text{iododeoxycytidine}$ (IdC) triphosphate was synthesized and incorporated enzymatically into defined positions of the plasmid pBR322. After storage under various conditions, the stable end products were analyzed using radio-GC, radio-HPLC, and electron microscopy. In addition, solutions of ^{14}{\rm C}\text{-}{\rm IdC}\text{-labeled}$ DNA containing Na125 I as an internal radiation source were studied to investigate the influence of internal radiolysis. Transmutation of the covalently bound 125 I leads to complete destruction of the labeled nucleotide, giving rise to 14 CO2 and ^{14}{\rm CO}$ as major products. Fragmentation of the pyrimidine base is independent of solvent and DNA configuration. Internal radiolysis caused by Na125 I leads to only minor damage. Electron microscopy studies reveal that decay-induced double strand breaks (dsb) occur both at the site of decay and in areas as far as hundreds of base pairs apart from that site. Number and distribution of the breaks is strongly dependent on solvent and DNA configuration. A direct correlation exists between the extent of fragmentation of the nucleotide and the mean number of dsb. |
| doi_str_mv | 10.2307/3576393 |
| format | Article |
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After storage under various conditions, the stable end products were analyzed using radio-GC, radio-HPLC, and electron microscopy. In addition, solutions of ^{14}{\rm C}\text{-}{\rm IdC}\text{-labeled}$ DNA containing Na125 I as an internal radiation source were studied to investigate the influence of internal radiolysis. Transmutation of the covalently bound 125 I leads to complete destruction of the labeled nucleotide, giving rise to 14 CO2 and ^{14}{\rm CO}$ as major products. Fragmentation of the pyrimidine base is independent of solvent and DNA configuration. Internal radiolysis caused by Na125 I leads to only minor damage. Electron microscopy studies reveal that decay-induced double strand breaks (dsb) occur both at the site of decay and in areas as far as hundreds of base pairs apart from that site. Number and distribution of the breaks is strongly dependent on solvent and DNA configuration. A direct correlation exists between the extent of fragmentation of the nucleotide and the mean number of dsb.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3576393</identifier><identifier>PMID: 3975356</identifier><identifier>CODEN: RAREAE</identifier><language>eng</language><publisher>Oak Brook, Il: Academic Press, Inc</publisher><subject>560111 - Radiation Effects on Biochemicals- In Vitro- (-1987) ; ALKALI METAL COMPOUNDS ; BACTERIA ; BETA DECAY RADIOISOTOPES ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; CARBON 14 COMPOUNDS ; CELL CONSTITUENTS ; CHEMICAL RADIATION EFFECTS ; CHEMICAL REACTIONS ; CHEMISTRY ; CHROMATOGRAPHY ; DATA ; DAYS LIVING RADIOISOTOPES ; DECOMPOSITION ; Deoxycytidine - analogs & derivatives ; DNA ; DNA - radiation effects ; DNA damage ; DNA POLYMERASES ; DOUBLE LABELLING ; ELECTRON CAPTURE RADIOISOTOPES ; ELECTRON MICROSCOPY ; ENZYMES ; ESCHERICHIA COLI ; EXPERIMENTAL DATA ; Fundamental and applied biological sciences. Psychology ; GAS CHROMATOGRAPHY ; HALIDES ; HALOGEN COMPOUNDS ; INFORMATION ; INORGANIC PHOSPHORS ; INTERMEDIATE MASS NUCLEI ; IODIDES ; IODINE 125 ; IODINE COMPOUNDS ; IODINE ISOTOPES ; Iodine Radioisotopes ; ISOTOPES ; LABELLED COMPOUNDS ; LABELLING ; LIQUID COLUMN CHROMATOGRAPHY ; MICROORGANISMS ; MICROSCOPY ; Microscopy, Electron ; Molecular and cellular biology ; Molecular genetics ; Molecules ; Mutagenesis. Repair ; NUCLEI ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; NUCLEOTIDYLTRANSFERASES ; NUMERICAL DATA ; ODD-EVEN NUCLEI ; ORGANIC COMPOUNDS ; ORGANIC HALOGEN COMPOUNDS ; ORGANIC IODINE COMPOUNDS ; Phosphates ; PHOSPHORS ; PHOSPHORUS-GROUP TRANSFERASES ; PLASMIDS ; Plasmids - radiation effects ; POLYMERASES ; RADIATION CHEMISTRY ; Radiation damage ; RADIATION EFFECTS ; Radiation Genetics ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; Radioactive decay ; Radioactivity ; RADIOINDUCTION ; RADIOISOTOPES ; RADIOLYSIS ; RIBOSIDES ; SEPARATION PROCESSES ; SODIUM COMPOUNDS ; SODIUM IODIDES ; Solvents ; STRAND BREAKS ; TRANSFERASES ; TRANSMISSION ELECTRON MICROSCOPY</subject><ispartof>Radiat. Res.; (United States), 1985-02, Vol.101 (2), p.262-278</ispartof><rights>Copyright 1985 Academic Press, Inc.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c276t-c52b10a145ee29d582d06d257e2be9d3c8bcf5e0d42f602cfa217fc0ab2195a33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3576393$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3576393$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,882,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9278644$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3975356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5854809$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Linz, Ute</creatorcontrib><creatorcontrib>Stöcklin, G.</creatorcontrib><creatorcontrib>Kernforschungsanlage, Juelich, West Germany</creatorcontrib><title>Chemical and Biological Consequences of the Radioactive Decay of Iodine-125 in Plasmid DNA</title><title>Radiat. Res.; (United States)</title><addtitle>Radiat Res</addtitle><description>Doubly labeled $[{\rm U}\text{-}{}^{14}{\rm C},\ 5\text{-}{}^{125}{\rm I}]\text{iododeoxycytidine}$ (IdC) triphosphate was synthesized and incorporated enzymatically into defined positions of the plasmid pBR322. After storage under various conditions, the stable end products were analyzed using radio-GC, radio-HPLC, and electron microscopy. In addition, solutions of ^{14}{\rm C}\text{-}{\rm IdC}\text{-labeled}$ DNA containing Na125 I as an internal radiation source were studied to investigate the influence of internal radiolysis. Transmutation of the covalently bound 125 I leads to complete destruction of the labeled nucleotide, giving rise to 14 CO2 and ^{14}{\rm CO}$ as major products. Fragmentation of the pyrimidine base is independent of solvent and DNA configuration. Internal radiolysis caused by Na125 I leads to only minor damage. Electron microscopy studies reveal that decay-induced double strand breaks (dsb) occur both at the site of decay and in areas as far as hundreds of base pairs apart from that site. Number and distribution of the breaks is strongly dependent on solvent and DNA configuration. A direct correlation exists between the extent of fragmentation of the nucleotide and the mean number of dsb.</description><subject>560111 - Radiation Effects on Biochemicals- In Vitro- (-1987)</subject><subject>ALKALI METAL COMPOUNDS</subject><subject>BACTERIA</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>CARBON 14 COMPOUNDS</subject><subject>CELL CONSTITUENTS</subject><subject>CHEMICAL RADIATION EFFECTS</subject><subject>CHEMICAL REACTIONS</subject><subject>CHEMISTRY</subject><subject>CHROMATOGRAPHY</subject><subject>DATA</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DECOMPOSITION</subject><subject>Deoxycytidine - analogs & derivatives</subject><subject>DNA</subject><subject>DNA - radiation effects</subject><subject>DNA damage</subject><subject>DNA POLYMERASES</subject><subject>DOUBLE LABELLING</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>ELECTRON MICROSCOPY</subject><subject>ENZYMES</subject><subject>ESCHERICHIA COLI</subject><subject>EXPERIMENTAL DATA</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GAS CHROMATOGRAPHY</subject><subject>HALIDES</subject><subject>HALOGEN COMPOUNDS</subject><subject>INFORMATION</subject><subject>INORGANIC PHOSPHORS</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>IODIDES</subject><subject>IODINE 125</subject><subject>IODINE COMPOUNDS</subject><subject>IODINE ISOTOPES</subject><subject>Iodine Radioisotopes</subject><subject>ISOTOPES</subject><subject>LABELLED COMPOUNDS</subject><subject>LABELLING</subject><subject>LIQUID COLUMN CHROMATOGRAPHY</subject><subject>MICROORGANISMS</subject><subject>MICROSCOPY</subject><subject>Microscopy, Electron</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecules</subject><subject>Mutagenesis. Repair</subject><subject>NUCLEI</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>NUCLEOTIDYLTRANSFERASES</subject><subject>NUMERICAL DATA</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC HALOGEN COMPOUNDS</subject><subject>ORGANIC IODINE COMPOUNDS</subject><subject>Phosphates</subject><subject>PHOSPHORS</subject><subject>PHOSPHORUS-GROUP TRANSFERASES</subject><subject>PLASMIDS</subject><subject>Plasmids - radiation effects</subject><subject>POLYMERASES</subject><subject>RADIATION CHEMISTRY</subject><subject>Radiation damage</subject><subject>RADIATION EFFECTS</subject><subject>Radiation Genetics</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>Radioactive decay</subject><subject>Radioactivity</subject><subject>RADIOINDUCTION</subject><subject>RADIOISOTOPES</subject><subject>RADIOLYSIS</subject><subject>RIBOSIDES</subject><subject>SEPARATION PROCESSES</subject><subject>SODIUM COMPOUNDS</subject><subject>SODIUM IODIDES</subject><subject>Solvents</subject><subject>STRAND BREAKS</subject><subject>TRANSFERASES</subject><subject>TRANSMISSION ELECTRON MICROSCOPY</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1LwzAUhoMoc07xFwhBBK-q-Wia5nJ2fgyGiuiNNyVNTl1G18ymE_bv7VzRK68OL-_De-BB6JSSK8aJvOZCJlzxPTSkiqeRiEm8j4aEcB5JkcpDdBTCgnSZJmqABlxJwUUyRO_ZHJbO6Arr2uIb5yv_8RMzXwf4XENtIGBf4nYO-EVb57Vp3RfgCRi92RZTb10NEWUCuxo_VzosncWTx_ExOih1FeCkvyP0dnf7mj1Es6f7aTaeRYbJpI2MYAUlmsYCgCkrUmZJYpmQwApQlpu0MKUAYmNWJoSZUjMqS0N0wagSmvMROt_t-tC6PBjXgpkbX9dg2lykIk6J6qDLHWQaH0IDZb5q3FI3m5ySfGsw7w125NmOXK2LJdhfrlfW9Rd9r0Mnqmx0bVz4xRSTaRLHf9gitL7599s3YxqAxw</recordid><startdate>198502</startdate><enddate>198502</enddate><creator>Linz, Ute</creator><creator>Stöcklin, G.</creator><general>Academic Press, Inc</general><general>Radiation Research Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>198502</creationdate><title>Chemical and Biological Consequences of the Radioactive Decay of Iodine-125 in Plasmid DNA</title><author>Linz, Ute ; Stöcklin, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c276t-c52b10a145ee29d582d06d257e2be9d3c8bcf5e0d42f602cfa217fc0ab2195a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>560111 - Radiation Effects on Biochemicals- In Vitro- (-1987)</topic><topic>ALKALI METAL COMPOUNDS</topic><topic>BACTERIA</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>CARBON 14 COMPOUNDS</topic><topic>CELL CONSTITUENTS</topic><topic>CHEMICAL RADIATION EFFECTS</topic><topic>CHEMICAL REACTIONS</topic><topic>CHEMISTRY</topic><topic>CHROMATOGRAPHY</topic><topic>DATA</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DECOMPOSITION</topic><topic>Deoxycytidine - analogs & derivatives</topic><topic>DNA</topic><topic>DNA - radiation effects</topic><topic>DNA damage</topic><topic>DNA POLYMERASES</topic><topic>DOUBLE LABELLING</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>ELECTRON MICROSCOPY</topic><topic>ENZYMES</topic><topic>ESCHERICHIA COLI</topic><topic>EXPERIMENTAL DATA</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GAS CHROMATOGRAPHY</topic><topic>HALIDES</topic><topic>HALOGEN COMPOUNDS</topic><topic>INFORMATION</topic><topic>INORGANIC PHOSPHORS</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>IODIDES</topic><topic>IODINE 125</topic><topic>IODINE COMPOUNDS</topic><topic>IODINE ISOTOPES</topic><topic>Iodine Radioisotopes</topic><topic>ISOTOPES</topic><topic>LABELLED COMPOUNDS</topic><topic>LABELLING</topic><topic>LIQUID COLUMN CHROMATOGRAPHY</topic><topic>MICROORGANISMS</topic><topic>MICROSCOPY</topic><topic>Microscopy, Electron</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecules</topic><topic>Mutagenesis. Repair</topic><topic>NUCLEI</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>NUCLEOTIDYLTRANSFERASES</topic><topic>NUMERICAL DATA</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC HALOGEN COMPOUNDS</topic><topic>ORGANIC IODINE COMPOUNDS</topic><topic>Phosphates</topic><topic>PHOSPHORS</topic><topic>PHOSPHORUS-GROUP TRANSFERASES</topic><topic>PLASMIDS</topic><topic>Plasmids - radiation effects</topic><topic>POLYMERASES</topic><topic>RADIATION CHEMISTRY</topic><topic>Radiation damage</topic><topic>RADIATION EFFECTS</topic><topic>Radiation Genetics</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>Radioactive decay</topic><topic>Radioactivity</topic><topic>RADIOINDUCTION</topic><topic>RADIOISOTOPES</topic><topic>RADIOLYSIS</topic><topic>RIBOSIDES</topic><topic>SEPARATION PROCESSES</topic><topic>SODIUM COMPOUNDS</topic><topic>SODIUM IODIDES</topic><topic>Solvents</topic><topic>STRAND BREAKS</topic><topic>TRANSFERASES</topic><topic>TRANSMISSION ELECTRON MICROSCOPY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Linz, Ute</creatorcontrib><creatorcontrib>Stöcklin, G.</creatorcontrib><creatorcontrib>Kernforschungsanlage, Juelich, West Germany</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Radiat. Res.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Linz, Ute</au><au>Stöcklin, G.</au><aucorp>Kernforschungsanlage, Juelich, West Germany</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical and Biological Consequences of the Radioactive Decay of Iodine-125 in Plasmid DNA</atitle><jtitle>Radiat. Res.; (United States)</jtitle><addtitle>Radiat Res</addtitle><date>1985-02</date><risdate>1985</risdate><volume>101</volume><issue>2</issue><spage>262</spage><epage>278</epage><pages>262-278</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><coden>RAREAE</coden><abstract>Doubly labeled $[{\rm U}\text{-}{}^{14}{\rm C},\ 5\text{-}{}^{125}{\rm I}]\text{iododeoxycytidine}$ (IdC) triphosphate was synthesized and incorporated enzymatically into defined positions of the plasmid pBR322. After storage under various conditions, the stable end products were analyzed using radio-GC, radio-HPLC, and electron microscopy. In addition, solutions of ^{14}{\rm C}\text{-}{\rm IdC}\text{-labeled}$ DNA containing Na125 I as an internal radiation source were studied to investigate the influence of internal radiolysis. Transmutation of the covalently bound 125 I leads to complete destruction of the labeled nucleotide, giving rise to 14 CO2 and ^{14}{\rm CO}$ as major products. Fragmentation of the pyrimidine base is independent of solvent and DNA configuration. Internal radiolysis caused by Na125 I leads to only minor damage. Electron microscopy studies reveal that decay-induced double strand breaks (dsb) occur both at the site of decay and in areas as far as hundreds of base pairs apart from that site. Number and distribution of the breaks is strongly dependent on solvent and DNA configuration. A direct correlation exists between the extent of fragmentation of the nucleotide and the mean number of dsb.</abstract><cop>Oak Brook, Il</cop><pub>Academic Press, Inc</pub><pmid>3975356</pmid><doi>10.2307/3576393</doi><tpages>17</tpages></addata></record> |
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| ispartof | Radiat. Res.; (United States), 1985-02, Vol.101 (2), p.262-278 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_crossref_primary_10_2307_3576393 |
| source | MEDLINE; Jstor Complete Legacy |
| subjects | 560111 - Radiation Effects on Biochemicals- In Vitro- (-1987) ALKALI METAL COMPOUNDS BACTERIA BETA DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS CARBON 14 COMPOUNDS CELL CONSTITUENTS CHEMICAL RADIATION EFFECTS CHEMICAL REACTIONS CHEMISTRY CHROMATOGRAPHY DATA DAYS LIVING RADIOISOTOPES DECOMPOSITION Deoxycytidine - analogs & derivatives DNA DNA - radiation effects DNA damage DNA POLYMERASES DOUBLE LABELLING ELECTRON CAPTURE RADIOISOTOPES ELECTRON MICROSCOPY ENZYMES ESCHERICHIA COLI EXPERIMENTAL DATA Fundamental and applied biological sciences. Psychology GAS CHROMATOGRAPHY HALIDES HALOGEN COMPOUNDS INFORMATION INORGANIC PHOSPHORS INTERMEDIATE MASS NUCLEI IODIDES IODINE 125 IODINE COMPOUNDS IODINE ISOTOPES Iodine Radioisotopes ISOTOPES LABELLED COMPOUNDS LABELLING LIQUID COLUMN CHROMATOGRAPHY MICROORGANISMS MICROSCOPY Microscopy, Electron Molecular and cellular biology Molecular genetics Molecules Mutagenesis. Repair NUCLEI NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES NUCLEOTIDYLTRANSFERASES NUMERICAL DATA ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC IODINE COMPOUNDS Phosphates PHOSPHORS PHOSPHORUS-GROUP TRANSFERASES PLASMIDS Plasmids - radiation effects POLYMERASES RADIATION CHEMISTRY Radiation damage RADIATION EFFECTS Radiation Genetics RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Radioactive decay Radioactivity RADIOINDUCTION RADIOISOTOPES RADIOLYSIS RIBOSIDES SEPARATION PROCESSES SODIUM COMPOUNDS SODIUM IODIDES Solvents STRAND BREAKS TRANSFERASES TRANSMISSION ELECTRON MICROSCOPY |
| title | Chemical and Biological Consequences of the Radioactive Decay of Iodine-125 in Plasmid DNA |
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