Radium Retention in Mature Beagles Injected at 5 Years of Age
Retention of 226 Ra was substantially lower in mature beagles injected at 5 years of age compared to corresponding values for young adult beagles injected at 17 months of age. As with young adults, the percentage retention in mature dogs given about 10 μCi/kg exceeded that in mature dogs given 4 μCi...
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| Veröffentlicht in: | Radiat. Res.; (United States) 1983-04, Vol.94 (1), p.210-216 |
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| container_title | Radiat. Res.; (United States) |
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| creator | Lloyd, R. D. Bruenger, F. W. Jones, C. W. Taylor, G. N. Mays, C. W. |
| description | Retention of 226 Ra was substantially lower in mature beagles injected at 5 years of age compared to corresponding values for young adult beagles injected at 17 months of age. As with young adults, the percentage retention in mature dogs given about 10 μCi/kg exceeded that in mature dogs given 4 μCi/kg or less. Percentage retention, R, at t days after the injection of 10 μCi/kg in mature beagles could be represented by the equation, $R=64.1e^{-0.233t}+13.0e^{-0.00481t}+22.9e^{-0.000329t}$, and for mature beagles given 4 μCi/kg or less, $R=38.8e^{-0.40t}+30.6e^{-0.0424t}+11.9e^{-0.00567t}+18.7e^{-0.000352t}$. Measured ^{222}{\rm Rn}/{}^{226}{\rm Ra}$ ratios in bone were similar in mature and young adults. Roughly 66% of the injected radium was excreted by mature dogs during the first 3 weeks, about two-thirds of the total excretion appearing in the feces. Distribution of 226 Ra within the skeleton was similar in mature and young adult beagles. |
| doi_str_mv | 10.2307/3575876 |
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D. ; Bruenger, F. W. ; Jones, C. W. ; Taylor, G. N. ; Mays, C. W.</creator><creatorcontrib>Lloyd, R. D. ; Bruenger, F. W. ; Jones, C. W. ; Taylor, G. N. ; Mays, C. W. ; Univ. of Utah, Salt Lake City</creatorcontrib><description>Retention of 226 Ra was substantially lower in mature beagles injected at 5 years of age compared to corresponding values for young adult beagles injected at 17 months of age. As with young adults, the percentage retention in mature dogs given about 10 μCi/kg exceeded that in mature dogs given 4 μCi/kg or less. Percentage retention, R, at t days after the injection of 10 μCi/kg in mature beagles could be represented by the equation, $R=64.1e^{-0.233t}+13.0e^{-0.00481t}+22.9e^{-0.000329t}$, and for mature beagles given 4 μCi/kg or less, $R=38.8e^{-0.40t}+30.6e^{-0.0424t}+11.9e^{-0.00567t}+18.7e^{-0.000352t}$. Measured ^{222}{\rm Rn}/{}^{226}{\rm Ra}$ ratios in bone were similar in mature and young adults. Roughly 66% of the injected radium was excreted by mature dogs during the first 3 weeks, about two-thirds of the total excretion appearing in the feces. Distribution of 226 Ra within the skeleton was similar in mature and young adult beagles.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3575876</identifier><identifier>PMID: 6856767</identifier><language>eng</language><publisher>United States: Academic Press, Inc</publisher><subject>560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987) ; ADULTS ; Age ; AGE DEPENDENCE ; Age Factors ; AGE GROUPS ; ALKALINE EARTH ISOTOPES ; ALPHA DECAY RADIOISOTOPES ; ANIMALS ; BEAGLES ; BODY ; Body Burden ; Bone and Bones - analysis ; Bone and Bones - metabolism ; Bone Neoplasms - etiology ; Bones ; CLEARANCE ; Correspondence ; DATA ; DAYS LIVING RADIOISOTOPES ; DOGS ; EVEN-EVEN NUCLEI ; EXCRETION ; EXPERIMENTAL DATA ; Feces ; Feces - analysis ; FUNCTIONS ; HEAVY NUCLEI ; INFORMATION ; INJECTION ; INTAKE ; INTRAVENOUS INJECTION ; ISOTOPES ; MAMMALS ; Neoplasms, Experimental - etiology ; Neoplasms, Radiation-Induced - etiology ; NUCLEI ; NUMERICAL DATA ; ORGANS ; Radiation dosage ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIOISOTOPES ; RADIONUCLIDE KINETICS ; Radium ; Radium - administration & dosage ; Radium - metabolism ; RADIUM 226 ; RADIUM ISOTOPES ; Radon ; Radon - analysis ; RADON 222 ; RADON ISOTOPES ; RETENTION ; RETENTION FUNCTIONS ; SKELETON ; Spectrometry, Gamma ; Time Factors ; VERTEBRATES ; YEARS LIVING RADIOISOTOPES ; Young adults</subject><ispartof>Radiat. Res.; (United States), 1983-04, Vol.94 (1), p.210-216</ispartof><rights>Copyright 1983 Academic Press, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-604c40bcb124186a5115e09ed8f8453f6db4a8d122d048732cc4730c99501aba3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3575876$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3575876$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,881,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6856767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5578325$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Lloyd, R. D.</creatorcontrib><creatorcontrib>Bruenger, F. W.</creatorcontrib><creatorcontrib>Jones, C. W.</creatorcontrib><creatorcontrib>Taylor, G. N.</creatorcontrib><creatorcontrib>Mays, C. W.</creatorcontrib><creatorcontrib>Univ. of Utah, Salt Lake City</creatorcontrib><title>Radium Retention in Mature Beagles Injected at 5 Years of Age</title><title>Radiat. Res.; (United States)</title><addtitle>Radiat Res</addtitle><description>Retention of 226 Ra was substantially lower in mature beagles injected at 5 years of age compared to corresponding values for young adult beagles injected at 17 months of age. As with young adults, the percentage retention in mature dogs given about 10 μCi/kg exceeded that in mature dogs given 4 μCi/kg or less. Percentage retention, R, at t days after the injection of 10 μCi/kg in mature beagles could be represented by the equation, $R=64.1e^{-0.233t}+13.0e^{-0.00481t}+22.9e^{-0.000329t}$, and for mature beagles given 4 μCi/kg or less, $R=38.8e^{-0.40t}+30.6e^{-0.0424t}+11.9e^{-0.00567t}+18.7e^{-0.000352t}$. Measured ^{222}{\rm Rn}/{}^{226}{\rm Ra}$ ratios in bone were similar in mature and young adults. Roughly 66% of the injected radium was excreted by mature dogs during the first 3 weeks, about two-thirds of the total excretion appearing in the feces. Distribution of 226 Ra within the skeleton was similar in mature and young adult beagles.</description><subject>560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)</subject><subject>ADULTS</subject><subject>Age</subject><subject>AGE DEPENDENCE</subject><subject>Age Factors</subject><subject>AGE GROUPS</subject><subject>ALKALINE EARTH ISOTOPES</subject><subject>ALPHA DECAY RADIOISOTOPES</subject><subject>ANIMALS</subject><subject>BEAGLES</subject><subject>BODY</subject><subject>Body Burden</subject><subject>Bone and Bones - analysis</subject><subject>Bone and Bones - metabolism</subject><subject>Bone Neoplasms - etiology</subject><subject>Bones</subject><subject>CLEARANCE</subject><subject>Correspondence</subject><subject>DATA</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DOGS</subject><subject>EVEN-EVEN NUCLEI</subject><subject>EXCRETION</subject><subject>EXPERIMENTAL DATA</subject><subject>Feces</subject><subject>Feces - analysis</subject><subject>FUNCTIONS</subject><subject>HEAVY NUCLEI</subject><subject>INFORMATION</subject><subject>INJECTION</subject><subject>INTAKE</subject><subject>INTRAVENOUS INJECTION</subject><subject>ISOTOPES</subject><subject>MAMMALS</subject><subject>Neoplasms, Experimental - etiology</subject><subject>Neoplasms, Radiation-Induced - etiology</subject><subject>NUCLEI</subject><subject>NUMERICAL DATA</subject><subject>ORGANS</subject><subject>Radiation dosage</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOISOTOPES</subject><subject>RADIONUCLIDE KINETICS</subject><subject>Radium</subject><subject>Radium - administration & dosage</subject><subject>Radium - metabolism</subject><subject>RADIUM 226</subject><subject>RADIUM ISOTOPES</subject><subject>Radon</subject><subject>Radon - analysis</subject><subject>RADON 222</subject><subject>RADON ISOTOPES</subject><subject>RETENTION</subject><subject>RETENTION FUNCTIONS</subject><subject>SKELETON</subject><subject>Spectrometry, Gamma</subject><subject>Time Factors</subject><subject>VERTEBRATES</subject><subject>YEARS LIVING RADIOISOTOPES</subject><subject>Young adults</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLAzEUhYMotVbxFwhBBFejeSezcFGLj0JFKLpwNWSSO3VKO1OSzMJ_75Qp7lxdDt_H4XIQuqTkjnGi77nU0mh1hMY05yaTgohjNCaE82wPTtFZjGvSZ6ryERopI5VWeoweltbX3RYvIUGT6rbBdYPfbOoC4Eewqw1EPG_W4BJ4bBOW-AtsiLit8HQF5-ikspsIF4c7QZ_PTx-z12zx_jKfTReZ45ylTBHhBCldSZmgRllJqQSSgzeVEZJXypfCGk8Z80QYzZlzQnPi8lwSakvLJ-h66G1jqovo6gTu27VN0_9VSKkNZ7KXbgfJhTbGAFWxC_XWhp-CkmI_UnEYqTevBnPXlVvwf95hlZ7fDHwdUxv-rfkFQDlpBA</recordid><startdate>198304</startdate><enddate>198304</enddate><creator>Lloyd, R. D.</creator><creator>Bruenger, F. W.</creator><creator>Jones, C. W.</creator><creator>Taylor, G. N.</creator><creator>Mays, C. W.</creator><general>Academic Press, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>198304</creationdate><title>Radium Retention in Mature Beagles Injected at 5 Years of Age</title><author>Lloyd, R. D. ; Bruenger, F. W. ; Jones, C. W. ; Taylor, G. N. ; Mays, C. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-604c40bcb124186a5115e09ed8f8453f6db4a8d122d048732cc4730c99501aba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)</topic><topic>ADULTS</topic><topic>Age</topic><topic>AGE DEPENDENCE</topic><topic>Age Factors</topic><topic>AGE GROUPS</topic><topic>ALKALINE EARTH ISOTOPES</topic><topic>ALPHA DECAY RADIOISOTOPES</topic><topic>ANIMALS</topic><topic>BEAGLES</topic><topic>BODY</topic><topic>Body Burden</topic><topic>Bone and Bones - analysis</topic><topic>Bone and Bones - metabolism</topic><topic>Bone Neoplasms - etiology</topic><topic>Bones</topic><topic>CLEARANCE</topic><topic>Correspondence</topic><topic>DATA</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DOGS</topic><topic>EVEN-EVEN NUCLEI</topic><topic>EXCRETION</topic><topic>EXPERIMENTAL DATA</topic><topic>Feces</topic><topic>Feces - analysis</topic><topic>FUNCTIONS</topic><topic>HEAVY NUCLEI</topic><topic>INFORMATION</topic><topic>INJECTION</topic><topic>INTAKE</topic><topic>INTRAVENOUS INJECTION</topic><topic>ISOTOPES</topic><topic>MAMMALS</topic><topic>Neoplasms, Experimental - etiology</topic><topic>Neoplasms, Radiation-Induced - etiology</topic><topic>NUCLEI</topic><topic>NUMERICAL DATA</topic><topic>ORGANS</topic><topic>Radiation dosage</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOISOTOPES</topic><topic>RADIONUCLIDE KINETICS</topic><topic>Radium</topic><topic>Radium - administration & dosage</topic><topic>Radium - metabolism</topic><topic>RADIUM 226</topic><topic>RADIUM ISOTOPES</topic><topic>Radon</topic><topic>Radon - analysis</topic><topic>RADON 222</topic><topic>RADON ISOTOPES</topic><topic>RETENTION</topic><topic>RETENTION FUNCTIONS</topic><topic>SKELETON</topic><topic>Spectrometry, Gamma</topic><topic>Time Factors</topic><topic>VERTEBRATES</topic><topic>YEARS LIVING RADIOISOTOPES</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lloyd, R. D.</creatorcontrib><creatorcontrib>Bruenger, F. W.</creatorcontrib><creatorcontrib>Jones, C. W.</creatorcontrib><creatorcontrib>Taylor, G. N.</creatorcontrib><creatorcontrib>Mays, C. W.</creatorcontrib><creatorcontrib>Univ. of Utah, Salt Lake City</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Radiat. Res.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lloyd, R. D.</au><au>Bruenger, F. W.</au><au>Jones, C. W.</au><au>Taylor, G. N.</au><au>Mays, C. W.</au><aucorp>Univ. of Utah, Salt Lake City</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radium Retention in Mature Beagles Injected at 5 Years of Age</atitle><jtitle>Radiat. Res.; (United States)</jtitle><addtitle>Radiat Res</addtitle><date>1983-04</date><risdate>1983</risdate><volume>94</volume><issue>1</issue><spage>210</spage><epage>216</epage><pages>210-216</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>Retention of 226 Ra was substantially lower in mature beagles injected at 5 years of age compared to corresponding values for young adult beagles injected at 17 months of age. As with young adults, the percentage retention in mature dogs given about 10 μCi/kg exceeded that in mature dogs given 4 μCi/kg or less. Percentage retention, R, at t days after the injection of 10 μCi/kg in mature beagles could be represented by the equation, $R=64.1e^{-0.233t}+13.0e^{-0.00481t}+22.9e^{-0.000329t}$, and for mature beagles given 4 μCi/kg or less, $R=38.8e^{-0.40t}+30.6e^{-0.0424t}+11.9e^{-0.00567t}+18.7e^{-0.000352t}$. Measured ^{222}{\rm Rn}/{}^{226}{\rm Ra}$ ratios in bone were similar in mature and young adults. Roughly 66% of the injected radium was excreted by mature dogs during the first 3 weeks, about two-thirds of the total excretion appearing in the feces. Distribution of 226 Ra within the skeleton was similar in mature and young adult beagles.</abstract><cop>United States</cop><pub>Academic Press, Inc</pub><pmid>6856767</pmid><doi>10.2307/3575876</doi><tpages>7</tpages></addata></record> |
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| ispartof | Radiat. Res.; (United States), 1983-04, Vol.94 (1), p.210-216 |
| issn | 0033-7587 1938-5404 |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | 560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987) ADULTS Age AGE DEPENDENCE Age Factors AGE GROUPS ALKALINE EARTH ISOTOPES ALPHA DECAY RADIOISOTOPES ANIMALS BEAGLES BODY Body Burden Bone and Bones - analysis Bone and Bones - metabolism Bone Neoplasms - etiology Bones CLEARANCE Correspondence DATA DAYS LIVING RADIOISOTOPES DOGS EVEN-EVEN NUCLEI EXCRETION EXPERIMENTAL DATA Feces Feces - analysis FUNCTIONS HEAVY NUCLEI INFORMATION INJECTION INTAKE INTRAVENOUS INJECTION ISOTOPES MAMMALS Neoplasms, Experimental - etiology Neoplasms, Radiation-Induced - etiology NUCLEI NUMERICAL DATA ORGANS Radiation dosage RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RADIONUCLIDE KINETICS Radium Radium - administration & dosage Radium - metabolism RADIUM 226 RADIUM ISOTOPES Radon Radon - analysis RADON 222 RADON ISOTOPES RETENTION RETENTION FUNCTIONS SKELETON Spectrometry, Gamma Time Factors VERTEBRATES YEARS LIVING RADIOISOTOPES Young adults |
| title | Radium Retention in Mature Beagles Injected at 5 Years of Age |
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