Radiation Response of Synchronized 9L Rat Brain Tumor Cells Separated by Centrifugal Elutriation
Survival curves of 9L rat brain tumor cells separated by centrifugal elutriation in early G1 (≥97%), mid-S (≥80%), and $\text{mid-}{\rm G}_{2}$ (≥70%) have been measured after 0-1800 rad of 137 Cs γ rays. The D0, $D_{{\rm q}}$, and n values calculated from the cell survival curves at early G1, mid-S...
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| Veröffentlicht in: | Radiat. Res.; (United States) 1980-09, Vol.83 (3), p.633-643 |
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| description | Survival curves of 9L rat brain tumor cells separated by centrifugal elutriation in early G1 (≥97%), mid-S (≥80%), and $\text{mid-}{\rm G}_{2}$ (≥70%) have been measured after 0-1800 rad of 137 Cs γ rays. The D0, $D_{{\rm q}}$, and n values calculated from the cell survival curves at early G1, mid-S, and $\text{mid-}{\rm G}_{2}$ were not significantly different (P > 0.1). Identical results were found with three different elutriation-irradiation procedures: (1) elutriating, irradiating, and plating for colony formation; (2) irradiating, elutriating, and plating for colony formation; (3) elutriating to obtain G1 cells, allowing them to progress, then irradiating in S or G2 and plating for colony formation. After doses of 600 and 900 rad given to every fraction separated by centrifugal elutriation from an asynchronous population of 9L cells, a very small but significant increase in resistance (∼1.4) was found in late G1 cells. The survival curve obtained with these resistant cells after elutriation showed a significant (P < 0.05) increase in the value of D0. The absence of any substantial change in radiosensitivity throughout the cell cycle makes it unlikely that the BCNU-radiation interaction previously observed for 9L cells was caused by presynchronizing the cells into a radiation-sensitive phase of the cell cycle. |
| doi_str_mv | 10.2307/3575343 |
| format | Article |
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The D0, $D_{{\rm q}}$, and n values calculated from the cell survival curves at early G1, mid-S, and $\text{mid-}{\rm G}_{2}$ were not significantly different (P > 0.1). Identical results were found with three different elutriation-irradiation procedures: (1) elutriating, irradiating, and plating for colony formation; (2) irradiating, elutriating, and plating for colony formation; (3) elutriating to obtain G1 cells, allowing them to progress, then irradiating in S or G2 and plating for colony formation. After doses of 600 and 900 rad given to every fraction separated by centrifugal elutriation from an asynchronous population of 9L cells, a very small but significant increase in resistance (∼1.4) was found in late G1 cells. The survival curve obtained with these resistant cells after elutriation showed a significant (P < 0.05) increase in the value of D0. The absence of any substantial change in radiosensitivity throughout the cell cycle makes it unlikely that the BCNU-radiation interaction previously observed for 9L cells was caused by presynchronizing the cells into a radiation-sensitive phase of the cell cycle.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3575343</identifier><identifier>PMID: 7413925</identifier><language>eng</language><publisher>United States: Academic Press, Inc</publisher><subject>ALKALI METAL ISOTOPES ; ANIMAL CELLS ; ANIMALS ; AZINES ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; BODY ; BRAIN ; Brain neoplasms ; Brain Neoplasms - pathology ; Brain Neoplasms - radiotherapy ; CELL CULTURES ; CELL CYCLE ; Cell Division ; Cell lines ; Cell Separation - methods ; Cell Survival - radiation effects ; CENTRAL NERVOUS SYSTEM ; Centrifugation ; CESIUM 137 ; CESIUM ISOTOPES ; CHO cells ; COLONY FORMATION ; Cultured cells ; DATA ; Dose-Response Relationship, Radiation ; DOSE-RESPONSE RELATIONSHIPS ; ELECTROMAGNETIC RADIATION ; Elution ; EXPERIMENTAL DATA ; GAMMA RADIATION ; Gamma Rays ; HeLa cells ; HETEROCYCLIC COMPOUNDS ; INFORMATION ; Interphase ; IONIZING RADIATIONS ; ISOTOPES ; LABELLED COMPOUNDS ; MAMMALS ; Neoplasms, Experimental - pathology ; Neoplasms, Experimental - radiotherapy ; NERVOUS SYSTEM ; NUCLEI ; NUCLEOSIDES ; NUCLEOTIDES ; NUMERICAL DATA ; ODD-EVEN NUCLEI ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; ORGANS ; PYRIMIDINES ; RADIATION EFFECTS ; Radiation Tolerance ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIATIONS ; RADIOISOTOPES ; RADIOSENSITIVITY ; RATS ; RIBOSIDES ; RODENTS ; SEPARATION PROCESSES ; SURVIVAL CURVES ; SYNCHRONOUS CULTURES ; THYMIDINE ; Time Factors ; TRITIUM COMPOUNDS ; TUMOR CELLS ; Tumors ; VERTEBRATES ; YEARS LIVING RADIOISOTOPES 560121 -- Radiation Effects on Cells-- External Source-- (-1987)</subject><ispartof>Radiat. Res.; (United States), 1980-09, Vol.83 (3), p.633-643</ispartof><rights>Copyright 1980 Academic Press, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-2f15ff04f4d9e534f0009707863f84e9a1da2bf45159ee71d5805865e75fab523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3575343$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3575343$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7413925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6784742$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Keng, Peter C.</creatorcontrib><creatorcontrib>Wheeler, Kenneth T.</creatorcontrib><creatorcontrib>Univ. of Rochester, NY</creatorcontrib><title>Radiation Response of Synchronized 9L Rat Brain Tumor Cells Separated by Centrifugal Elutriation</title><title>Radiat. Res.; (United States)</title><addtitle>Radiat Res</addtitle><description>Survival curves of 9L rat brain tumor cells separated by centrifugal elutriation in early G1 (≥97%), mid-S (≥80%), and $\text{mid-}{\rm G}_{2}$ (≥70%) have been measured after 0-1800 rad of 137 Cs γ rays. The D0, $D_{{\rm q}}$, and n values calculated from the cell survival curves at early G1, mid-S, and $\text{mid-}{\rm G}_{2}$ were not significantly different (P > 0.1). Identical results were found with three different elutriation-irradiation procedures: (1) elutriating, irradiating, and plating for colony formation; (2) irradiating, elutriating, and plating for colony formation; (3) elutriating to obtain G1 cells, allowing them to progress, then irradiating in S or G2 and plating for colony formation. After doses of 600 and 900 rad given to every fraction separated by centrifugal elutriation from an asynchronous population of 9L cells, a very small but significant increase in resistance (∼1.4) was found in late G1 cells. The survival curve obtained with these resistant cells after elutriation showed a significant (P < 0.05) increase in the value of D0. The absence of any substantial change in radiosensitivity throughout the cell cycle makes it unlikely that the BCNU-radiation interaction previously observed for 9L cells was caused by presynchronizing the cells into a radiation-sensitive phase of the cell cycle.</description><subject>ALKALI METAL ISOTOPES</subject><subject>ANIMAL CELLS</subject><subject>ANIMALS</subject><subject>AZINES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BODY</subject><subject>BRAIN</subject><subject>Brain neoplasms</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>CELL CULTURES</subject><subject>CELL CYCLE</subject><subject>Cell Division</subject><subject>Cell lines</subject><subject>Cell Separation - methods</subject><subject>Cell Survival - radiation effects</subject><subject>CENTRAL NERVOUS SYSTEM</subject><subject>Centrifugation</subject><subject>CESIUM 137</subject><subject>CESIUM ISOTOPES</subject><subject>CHO cells</subject><subject>COLONY FORMATION</subject><subject>Cultured cells</subject><subject>DATA</subject><subject>Dose-Response Relationship, Radiation</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>Elution</subject><subject>EXPERIMENTAL DATA</subject><subject>GAMMA RADIATION</subject><subject>Gamma Rays</subject><subject>HeLa cells</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>INFORMATION</subject><subject>Interphase</subject><subject>IONIZING RADIATIONS</subject><subject>ISOTOPES</subject><subject>LABELLED COMPOUNDS</subject><subject>MAMMALS</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Neoplasms, Experimental - radiotherapy</subject><subject>NERVOUS SYSTEM</subject><subject>NUCLEI</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>NUMERICAL DATA</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>ORGANS</subject><subject>PYRIMIDINES</subject><subject>RADIATION EFFECTS</subject><subject>Radiation Tolerance</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIATIONS</subject><subject>RADIOISOTOPES</subject><subject>RADIOSENSITIVITY</subject><subject>RATS</subject><subject>RIBOSIDES</subject><subject>RODENTS</subject><subject>SEPARATION PROCESSES</subject><subject>SURVIVAL CURVES</subject><subject>SYNCHRONOUS CULTURES</subject><subject>THYMIDINE</subject><subject>Time Factors</subject><subject>TRITIUM COMPOUNDS</subject><subject>TUMOR CELLS</subject><subject>Tumors</subject><subject>VERTEBRATES</subject><subject>YEARS LIVING RADIOISOTOPES 560121 -- Radiation Effects on Cells-- External Source-- (-1987)</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLAzEUhYMotVbxFwhBBFejySSZTJZa6gMKQlvXY2YmsZFpMiSZRf31pra4c3Uf5-Nw7wHgEqO7nCB-TxhnhJIjMMaClBmjiB6DMUKEZJyV_BSchfCF0owLMQIjTjERORuDj4VsjYzGWbhQoXc2KOg0XG5ts_bOmm_VQjGHCxnho5fGwtWwcR5OVdcFuFS99DImpN6mlY3e6OFTdnDWDan_tT0HJ1p2QV0c6gS8P81W05ds_vb8On2YZw0hecxyjZnWiGraCpU-0elWwREvC6JLqoTErcxrTRlmQimOW1YiVhZMcaZlzXIyAdd7XxeiqUJjomrWjbNWNbEqeEk53UG3e6jxLgSvdNV7s5F-W2FU7XKsDjkm8mpP9kO9Ue0fdwgu6Td7_StE5_-1-QHHlHcM</recordid><startdate>198009</startdate><enddate>198009</enddate><creator>Keng, Peter C.</creator><creator>Wheeler, Kenneth T.</creator><general>Academic Press, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>198009</creationdate><title>Radiation Response of Synchronized 9L Rat Brain Tumor Cells Separated by Centrifugal Elutriation</title><author>Keng, Peter C. ; Wheeler, Kenneth T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-2f15ff04f4d9e534f0009707863f84e9a1da2bf45159ee71d5805865e75fab523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>ALKALI METAL ISOTOPES</topic><topic>ANIMAL CELLS</topic><topic>ANIMALS</topic><topic>AZINES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BODY</topic><topic>BRAIN</topic><topic>Brain neoplasms</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>CELL CULTURES</topic><topic>CELL CYCLE</topic><topic>Cell Division</topic><topic>Cell lines</topic><topic>Cell Separation - methods</topic><topic>Cell Survival - radiation effects</topic><topic>CENTRAL NERVOUS SYSTEM</topic><topic>Centrifugation</topic><topic>CESIUM 137</topic><topic>CESIUM ISOTOPES</topic><topic>CHO cells</topic><topic>COLONY FORMATION</topic><topic>Cultured cells</topic><topic>DATA</topic><topic>Dose-Response Relationship, Radiation</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>Elution</topic><topic>EXPERIMENTAL DATA</topic><topic>GAMMA RADIATION</topic><topic>Gamma Rays</topic><topic>HeLa cells</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>INFORMATION</topic><topic>Interphase</topic><topic>IONIZING RADIATIONS</topic><topic>ISOTOPES</topic><topic>LABELLED COMPOUNDS</topic><topic>MAMMALS</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Neoplasms, Experimental - radiotherapy</topic><topic>NERVOUS SYSTEM</topic><topic>NUCLEI</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>NUMERICAL DATA</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>ORGANS</topic><topic>PYRIMIDINES</topic><topic>RADIATION EFFECTS</topic><topic>Radiation Tolerance</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIATIONS</topic><topic>RADIOISOTOPES</topic><topic>RADIOSENSITIVITY</topic><topic>RATS</topic><topic>RIBOSIDES</topic><topic>RODENTS</topic><topic>SEPARATION PROCESSES</topic><topic>SURVIVAL CURVES</topic><topic>SYNCHRONOUS CULTURES</topic><topic>THYMIDINE</topic><topic>Time Factors</topic><topic>TRITIUM COMPOUNDS</topic><topic>TUMOR CELLS</topic><topic>Tumors</topic><topic>VERTEBRATES</topic><topic>YEARS LIVING RADIOISOTOPES 560121 -- Radiation Effects on Cells-- External Source-- (-1987)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keng, Peter C.</creatorcontrib><creatorcontrib>Wheeler, Kenneth T.</creatorcontrib><creatorcontrib>Univ. of Rochester, NY</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Radiat. Res.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keng, Peter C.</au><au>Wheeler, Kenneth T.</au><aucorp>Univ. of Rochester, NY</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiation Response of Synchronized 9L Rat Brain Tumor Cells Separated by Centrifugal Elutriation</atitle><jtitle>Radiat. Res.; (United States)</jtitle><addtitle>Radiat Res</addtitle><date>1980-09</date><risdate>1980</risdate><volume>83</volume><issue>3</issue><spage>633</spage><epage>643</epage><pages>633-643</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>Survival curves of 9L rat brain tumor cells separated by centrifugal elutriation in early G1 (≥97%), mid-S (≥80%), and $\text{mid-}{\rm G}_{2}$ (≥70%) have been measured after 0-1800 rad of 137 Cs γ rays. The D0, $D_{{\rm q}}$, and n values calculated from the cell survival curves at early G1, mid-S, and $\text{mid-}{\rm G}_{2}$ were not significantly different (P > 0.1). Identical results were found with three different elutriation-irradiation procedures: (1) elutriating, irradiating, and plating for colony formation; (2) irradiating, elutriating, and plating for colony formation; (3) elutriating to obtain G1 cells, allowing them to progress, then irradiating in S or G2 and plating for colony formation. After doses of 600 and 900 rad given to every fraction separated by centrifugal elutriation from an asynchronous population of 9L cells, a very small but significant increase in resistance (∼1.4) was found in late G1 cells. The survival curve obtained with these resistant cells after elutriation showed a significant (P < 0.05) increase in the value of D0. The absence of any substantial change in radiosensitivity throughout the cell cycle makes it unlikely that the BCNU-radiation interaction previously observed for 9L cells was caused by presynchronizing the cells into a radiation-sensitive phase of the cell cycle.</abstract><cop>United States</cop><pub>Academic Press, Inc</pub><pmid>7413925</pmid><doi>10.2307/3575343</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-7587 |
| ispartof | Radiat. Res.; (United States), 1980-09, Vol.83 (3), p.633-643 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_crossref_primary_10_2307_3575343 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | ALKALI METAL ISOTOPES ANIMAL CELLS ANIMALS AZINES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BODY BRAIN Brain neoplasms Brain Neoplasms - pathology Brain Neoplasms - radiotherapy CELL CULTURES CELL CYCLE Cell Division Cell lines Cell Separation - methods Cell Survival - radiation effects CENTRAL NERVOUS SYSTEM Centrifugation CESIUM 137 CESIUM ISOTOPES CHO cells COLONY FORMATION Cultured cells DATA Dose-Response Relationship, Radiation DOSE-RESPONSE RELATIONSHIPS ELECTROMAGNETIC RADIATION Elution EXPERIMENTAL DATA GAMMA RADIATION Gamma Rays HeLa cells HETEROCYCLIC COMPOUNDS INFORMATION Interphase IONIZING RADIATIONS ISOTOPES LABELLED COMPOUNDS MAMMALS Neoplasms, Experimental - pathology Neoplasms, Experimental - radiotherapy NERVOUS SYSTEM NUCLEI NUCLEOSIDES NUCLEOTIDES NUMERICAL DATA ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS PYRIMIDINES RADIATION EFFECTS Radiation Tolerance RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOISOTOPES RADIOSENSITIVITY RATS RIBOSIDES RODENTS SEPARATION PROCESSES SURVIVAL CURVES SYNCHRONOUS CULTURES THYMIDINE Time Factors TRITIUM COMPOUNDS TUMOR CELLS Tumors VERTEBRATES YEARS LIVING RADIOISOTOPES 560121 -- Radiation Effects on Cells-- External Source-- (-1987) |
| title | Radiation Response of Synchronized 9L Rat Brain Tumor Cells Separated by Centrifugal Elutriation |
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