Effects of Low-Level α Radiation on Intracellular Energy Metabolism
The effect on the adenosine triphosphate (ATP) content of cell samples irradiated with α particles of a mean LET of 135-141 keV/μm is described. Cells in logarithmic growth phase showed an ATP content about 50% below the unirradiated control value 5-15 sec after receiving a mean cellular dose of 25...
Gespeichert in:
| Veröffentlicht in: | Radiation research 1980-03, Vol.81 (3), p.393-401 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 401 |
|---|---|
| container_issue | 3 |
| container_start_page | 393 |
| container_title | Radiation research |
| container_volume | 81 |
| creator | Steinhäusler, F. Schaffer, S. Lee, C. C. O'Connor, J. Wrenn, M. E. |
| description | The effect on the adenosine triphosphate (ATP) content of cell samples irradiated with α particles of a mean LET of 135-141 keV/μm is described. Cells in logarithmic growth phase showed an ATP content about 50% below the unirradiated control value 5-15 sec after receiving a mean cellular dose of 25 rad (0.25 Gy). This was followed by a slow recovery up to control values after about 30 sec. Stationary cells responded with an increase in ATP content about threefold over that of the controls 20 sec after irradiation. Within the following 20 sec these elevated ATP values decreased to control levels. Additional measurements of 14 C uptake also showed pronounced differentiated changes in carbon uptake after irradiation for cells in logarithmic and stationary growth phase. The possible importance of these effects on bioenergetic processes as a compensatory reaction of the cellular system to an increased demand for energy is discussed. |
| doi_str_mv | 10.2307/3575198 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_cross</sourceid><recordid>TN_cdi_crossref_primary_10_2307_3575198</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>3575198</jstor_id><sourcerecordid>3575198</sourcerecordid><originalsourceid>FETCH-LOGICAL-c305t-52ec4c2d3def5e137eeb2ccd06d463097ce3752e6cb8f1f442667353f54c15033</originalsourceid><addsrcrecordid>eNp1kM1Kw0AUhQdRaqziEwizEFxFZ3LnJ1lKjVqICKLrMJnckZS0KTOp0sfyRXwmR1rcCRcOl_Nx4BxCzjm7zoDpG5Ba8iI_IAkvIE-lYOKQJIwBpFrm-pichLBg8eeqmJCJBsXygifkrnQO7Rjo4Gg1fKYVfmBPv7_oi2k7M3bDisabr0ZvLPb9pjeeliv071v6hKNphr4Ly1Ny5Ewf8GyvU_J2X77OHtPq-WE-u61SC0yOqczQCpu10KKTyEEjNpm1LVOtUMAKbRF0hJRtcsedEJlSGiQ4KSyXscqUXO1yrR9C8Ojqte-Wxm9rzurfGer9DJG82JHrTbPE9o_b947-5c5fhHHw_8b8ALgsYiQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effects of Low-Level α Radiation on Intracellular Energy Metabolism</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><creator>Steinhäusler, F. ; Schaffer, S. ; Lee, C. C. ; O'Connor, J. ; Wrenn, M. E.</creator><creatorcontrib>Steinhäusler, F. ; Schaffer, S. ; Lee, C. C. ; O'Connor, J. ; Wrenn, M. E.</creatorcontrib><description>The effect on the adenosine triphosphate (ATP) content of cell samples irradiated with α particles of a mean LET of 135-141 keV/μm is described. Cells in logarithmic growth phase showed an ATP content about 50% below the unirradiated control value 5-15 sec after receiving a mean cellular dose of 25 rad (0.25 Gy). This was followed by a slow recovery up to control values after about 30 sec. Stationary cells responded with an increase in ATP content about threefold over that of the controls 20 sec after irradiation. Within the following 20 sec these elevated ATP values decreased to control levels. Additional measurements of 14 C uptake also showed pronounced differentiated changes in carbon uptake after irradiation for cells in logarithmic and stationary growth phase. The possible importance of these effects on bioenergetic processes as a compensatory reaction of the cellular system to an increased demand for energy is discussed.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3575198</identifier><identifier>PMID: 7360891</identifier><language>eng</language><publisher>United States: Academic Press, Inc</publisher><subject>Adenosine Triphosphate - metabolism ; Alpha Particles ; Carbon Radioisotopes ; Cell Division - radiation effects ; Cell growth ; Chlorella - metabolism ; Chlorella - radiation effects ; Cultured cells ; Energy metabolism ; Energy Metabolism - radiation effects ; Energy Transfer ; Ionizing radiation ; Irradiation ; Radiation damage ; Radiation Dosage ; Radiobiology ; Radiocarbon ; Steepest descent method ; Time Factors</subject><ispartof>Radiation research, 1980-03, Vol.81 (3), p.393-401</ispartof><rights>Copyright 1980 Academic Press, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-52ec4c2d3def5e137eeb2ccd06d463097ce3752e6cb8f1f442667353f54c15033</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3575198$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3575198$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7360891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steinhäusler, F.</creatorcontrib><creatorcontrib>Schaffer, S.</creatorcontrib><creatorcontrib>Lee, C. C.</creatorcontrib><creatorcontrib>O'Connor, J.</creatorcontrib><creatorcontrib>Wrenn, M. E.</creatorcontrib><title>Effects of Low-Level α Radiation on Intracellular Energy Metabolism</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>The effect on the adenosine triphosphate (ATP) content of cell samples irradiated with α particles of a mean LET of 135-141 keV/μm is described. Cells in logarithmic growth phase showed an ATP content about 50% below the unirradiated control value 5-15 sec after receiving a mean cellular dose of 25 rad (0.25 Gy). This was followed by a slow recovery up to control values after about 30 sec. Stationary cells responded with an increase in ATP content about threefold over that of the controls 20 sec after irradiation. Within the following 20 sec these elevated ATP values decreased to control levels. Additional measurements of 14 C uptake also showed pronounced differentiated changes in carbon uptake after irradiation for cells in logarithmic and stationary growth phase. The possible importance of these effects on bioenergetic processes as a compensatory reaction of the cellular system to an increased demand for energy is discussed.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Alpha Particles</subject><subject>Carbon Radioisotopes</subject><subject>Cell Division - radiation effects</subject><subject>Cell growth</subject><subject>Chlorella - metabolism</subject><subject>Chlorella - radiation effects</subject><subject>Cultured cells</subject><subject>Energy metabolism</subject><subject>Energy Metabolism - radiation effects</subject><subject>Energy Transfer</subject><subject>Ionizing radiation</subject><subject>Irradiation</subject><subject>Radiation damage</subject><subject>Radiation Dosage</subject><subject>Radiobiology</subject><subject>Radiocarbon</subject><subject>Steepest descent method</subject><subject>Time Factors</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1Kw0AUhQdRaqziEwizEFxFZ3LnJ1lKjVqICKLrMJnckZS0KTOp0sfyRXwmR1rcCRcOl_Nx4BxCzjm7zoDpG5Ba8iI_IAkvIE-lYOKQJIwBpFrm-pichLBg8eeqmJCJBsXygifkrnQO7Rjo4Gg1fKYVfmBPv7_oi2k7M3bDisabr0ZvLPb9pjeeliv071v6hKNphr4Ly1Ny5Ewf8GyvU_J2X77OHtPq-WE-u61SC0yOqczQCpu10KKTyEEjNpm1LVOtUMAKbRF0hJRtcsedEJlSGiQ4KSyXscqUXO1yrR9C8Ojqte-Wxm9rzurfGer9DJG82JHrTbPE9o_b947-5c5fhHHw_8b8ALgsYiQ</recordid><startdate>198003</startdate><enddate>198003</enddate><creator>Steinhäusler, F.</creator><creator>Schaffer, S.</creator><creator>Lee, C. C.</creator><creator>O'Connor, J.</creator><creator>Wrenn, M. E.</creator><general>Academic Press, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198003</creationdate><title>Effects of Low-Level α Radiation on Intracellular Energy Metabolism</title><author>Steinhäusler, F. ; Schaffer, S. ; Lee, C. C. ; O'Connor, J. ; Wrenn, M. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-52ec4c2d3def5e137eeb2ccd06d463097ce3752e6cb8f1f442667353f54c15033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Alpha Particles</topic><topic>Carbon Radioisotopes</topic><topic>Cell Division - radiation effects</topic><topic>Cell growth</topic><topic>Chlorella - metabolism</topic><topic>Chlorella - radiation effects</topic><topic>Cultured cells</topic><topic>Energy metabolism</topic><topic>Energy Metabolism - radiation effects</topic><topic>Energy Transfer</topic><topic>Ionizing radiation</topic><topic>Irradiation</topic><topic>Radiation damage</topic><topic>Radiation Dosage</topic><topic>Radiobiology</topic><topic>Radiocarbon</topic><topic>Steepest descent method</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steinhäusler, F.</creatorcontrib><creatorcontrib>Schaffer, S.</creatorcontrib><creatorcontrib>Lee, C. C.</creatorcontrib><creatorcontrib>O'Connor, J.</creatorcontrib><creatorcontrib>Wrenn, M. E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Radiation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steinhäusler, F.</au><au>Schaffer, S.</au><au>Lee, C. C.</au><au>O'Connor, J.</au><au>Wrenn, M. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Low-Level α Radiation on Intracellular Energy Metabolism</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>1980-03</date><risdate>1980</risdate><volume>81</volume><issue>3</issue><spage>393</spage><epage>401</epage><pages>393-401</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>The effect on the adenosine triphosphate (ATP) content of cell samples irradiated with α particles of a mean LET of 135-141 keV/μm is described. Cells in logarithmic growth phase showed an ATP content about 50% below the unirradiated control value 5-15 sec after receiving a mean cellular dose of 25 rad (0.25 Gy). This was followed by a slow recovery up to control values after about 30 sec. Stationary cells responded with an increase in ATP content about threefold over that of the controls 20 sec after irradiation. Within the following 20 sec these elevated ATP values decreased to control levels. Additional measurements of 14 C uptake also showed pronounced differentiated changes in carbon uptake after irradiation for cells in logarithmic and stationary growth phase. The possible importance of these effects on bioenergetic processes as a compensatory reaction of the cellular system to an increased demand for energy is discussed.</abstract><cop>United States</cop><pub>Academic Press, Inc</pub><pmid>7360891</pmid><doi>10.2307/3575198</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-7587 |
| ispartof | Radiation research, 1980-03, Vol.81 (3), p.393-401 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_crossref_primary_10_2307_3575198 |
| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adenosine Triphosphate - metabolism Alpha Particles Carbon Radioisotopes Cell Division - radiation effects Cell growth Chlorella - metabolism Chlorella - radiation effects Cultured cells Energy metabolism Energy Metabolism - radiation effects Energy Transfer Ionizing radiation Irradiation Radiation damage Radiation Dosage Radiobiology Radiocarbon Steepest descent method Time Factors |
| title | Effects of Low-Level α Radiation on Intracellular Energy Metabolism |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T20%3A07%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Low-Level%20%CE%B1%20Radiation%20on%20Intracellular%20Energy%20Metabolism&rft.jtitle=Radiation%20research&rft.au=Steinh%C3%A4usler,%20F.&rft.date=1980-03&rft.volume=81&rft.issue=3&rft.spage=393&rft.epage=401&rft.pages=393-401&rft.issn=0033-7587&rft.eissn=1938-5404&rft_id=info:doi/10.2307/3575198&rft_dat=%3Cjstor_cross%3E3575198%3C/jstor_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/7360891&rft_jstor_id=3575198&rfr_iscdi=true |