The Effect of Colchicine on the Accumulation of Hydroxyproline and on Lung Compliance after Irradiation
The development of late radiation fibrosis in rat lung after a single dose of 750, 1000, 1250, or 1500 rad of γ radiation was studied. The concentration of hydroxyproline was measured to evaluate collagen deposition in irradiated and control lungs. At 120 days after irradiation a linear dose-respons...
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| Veröffentlicht in: | Radiat. Res.; (United States) 1978-01, Vol.73 (1), p.111-120 |
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| creator | Dubrawsky, C. Dubravsky, N. B. Withers, H. R. |
| description | The development of late radiation fibrosis in rat lung after a single dose of 750, 1000, 1250, or 1500 rad of γ radiation was studied. The concentration of hydroxyproline was measured to evaluate collagen deposition in irradiated and control lungs. At 120 days after irradiation a linear dose-response curve can be established. Colchicine, known to modify collagen secretion and deposition, was used to modify lung fibrosis after irradiation. It was found that collagen deposition can be reduced only if colchicine is injected when the lung collagen is being synthesized, namely around 90 days after irradiation with these doses. Lung compliance at intervals up to 150 days after irradiation is reduced mainly as a result of increase in lung weight, not collagen deposition. |
| doi_str_mv | 10.2307/3574577 |
| format | Article |
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B. ; Withers, H. R.</creator><creatorcontrib>Dubrawsky, C. ; Dubravsky, N. B. ; Withers, H. R. ; Univ. of Texas System Cancer Center, Houston</creatorcontrib><description>The development of late radiation fibrosis in rat lung after a single dose of 750, 1000, 1250, or 1500 rad of γ radiation was studied. The concentration of hydroxyproline was measured to evaluate collagen deposition in irradiated and control lungs. At 120 days after irradiation a linear dose-response curve can be established. Colchicine, known to modify collagen secretion and deposition, was used to modify lung fibrosis after irradiation. It was found that collagen deposition can be reduced only if colchicine is injected when the lung collagen is being synthesized, namely around 90 days after irradiation with these doses. Lung compliance at intervals up to 150 days after irradiation is reduced mainly as a result of increase in lung weight, not collagen deposition.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3574577</identifier><identifier>PMID: 622454</identifier><language>eng</language><publisher>United States: Academic Press, Inc</publisher><subject>560152 - Radiation Effects on Animals- Animals ; ALKALOIDS ; ANIMALS ; ANTIMITOTIC DRUGS ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; BIOSYNTHESIS ; BODY ; BODY AREAS ; CHEST ; COBALT 60 ; COBALT ISOTOPES ; COLCHICINE ; Colchicine - administration & dosage ; Colchicine - pharmacology ; COLLAGEN ; Collagen - metabolism ; Collagens ; DELAYED RADIATION EFFECTS ; DISEASES ; Dosage ; Dose response relationship ; Dose-Response Relationship, Drug ; DOSE-RESPONSE RELATIONSHIPS ; DRUGS ; ELECTROMAGNETIC RADIATION ; EXTERNAL IRRADIATION ; FIBROSIS ; GAMMA RADIATION ; Hydroxyproline - metabolism ; INHIBITION ; INTERMEDIATE MASS NUCLEI ; INTERNAL CONVERSION RADIOISOTOPES ; IONIZING RADIATIONS ; IRRADIATION ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; Lung Compliance - radiation effects ; LUNGS ; Male ; MAMMALS ; MINUTES LIVING RADIOISOTOPES ; NUCLEI ; ODD-ODD NUCLEI ; Organ Size ; ORGANIC COMPOUNDS ; ORGANS ; PARTIAL BODY IRRADIATION ; PATHOLOGICAL CHANGES ; PROTEINS ; Pulmonary compliance ; Pulmonary Fibrosis - etiology ; Pulmonary Fibrosis - metabolism ; Pulmonary Fibrosis - physiopathology ; Radiation dosage ; RADIATION EFFECTS ; Radiation Injuries, Experimental - metabolism ; Radiation Injuries, Experimental - physiopathology ; Radiation pneumonitis ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIATIONS ; RADIOINDUCTION ; RADIOISOTOPES ; RADIOSENSITIVITY EFFECTS ; RATS ; RESPIRATORY SYSTEM ; RODENTS ; SCLEROPROTEINS ; Secretion ; SYNTHESIS ; TIME DEPENDENCE ; Time Factors ; VERTEBRATES ; YEARS LIVING RADIOISOTOPES</subject><ispartof>Radiat. 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B.</creatorcontrib><creatorcontrib>Withers, H. R.</creatorcontrib><creatorcontrib>Univ. of Texas System Cancer Center, Houston</creatorcontrib><title>The Effect of Colchicine on the Accumulation of Hydroxyproline and on Lung Compliance after Irradiation</title><title>Radiat. Res.; (United States)</title><addtitle>Radiat Res</addtitle><description>The development of late radiation fibrosis in rat lung after a single dose of 750, 1000, 1250, or 1500 rad of γ radiation was studied. The concentration of hydroxyproline was measured to evaluate collagen deposition in irradiated and control lungs. At 120 days after irradiation a linear dose-response curve can be established. Colchicine, known to modify collagen secretion and deposition, was used to modify lung fibrosis after irradiation. It was found that collagen deposition can be reduced only if colchicine is injected when the lung collagen is being synthesized, namely around 90 days after irradiation with these doses. Lung compliance at intervals up to 150 days after irradiation is reduced mainly as a result of increase in lung weight, not collagen deposition.</description><subject>560152 - Radiation Effects on Animals- Animals</subject><subject>ALKALOIDS</subject><subject>ANIMALS</subject><subject>ANTIMITOTIC DRUGS</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BIOSYNTHESIS</subject><subject>BODY</subject><subject>BODY AREAS</subject><subject>CHEST</subject><subject>COBALT 60</subject><subject>COBALT ISOTOPES</subject><subject>COLCHICINE</subject><subject>Colchicine - administration & dosage</subject><subject>Colchicine - pharmacology</subject><subject>COLLAGEN</subject><subject>Collagen - metabolism</subject><subject>Collagens</subject><subject>DELAYED RADIATION EFFECTS</subject><subject>DISEASES</subject><subject>Dosage</subject><subject>Dose response relationship</subject><subject>Dose-Response Relationship, Drug</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>DRUGS</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>EXTERNAL IRRADIATION</subject><subject>FIBROSIS</subject><subject>GAMMA RADIATION</subject><subject>Hydroxyproline - metabolism</subject><subject>INHIBITION</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>INTERNAL CONVERSION RADIOISOTOPES</subject><subject>IONIZING RADIATIONS</subject><subject>IRRADIATION</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>Lung Compliance - radiation effects</subject><subject>LUNGS</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MINUTES LIVING RADIOISOTOPES</subject><subject>NUCLEI</subject><subject>ODD-ODD NUCLEI</subject><subject>Organ Size</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>PARTIAL BODY IRRADIATION</subject><subject>PATHOLOGICAL CHANGES</subject><subject>PROTEINS</subject><subject>Pulmonary compliance</subject><subject>Pulmonary Fibrosis - etiology</subject><subject>Pulmonary Fibrosis - metabolism</subject><subject>Pulmonary Fibrosis - physiopathology</subject><subject>Radiation dosage</subject><subject>RADIATION EFFECTS</subject><subject>Radiation Injuries, Experimental - metabolism</subject><subject>Radiation Injuries, Experimental - physiopathology</subject><subject>Radiation pneumonitis</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIATIONS</subject><subject>RADIOINDUCTION</subject><subject>RADIOISOTOPES</subject><subject>RADIOSENSITIVITY EFFECTS</subject><subject>RATS</subject><subject>RESPIRATORY SYSTEM</subject><subject>RODENTS</subject><subject>SCLEROPROTEINS</subject><subject>Secretion</subject><subject>SYNTHESIS</subject><subject>TIME DEPENDENCE</subject><subject>Time Factors</subject><subject>VERTEBRATES</subject><subject>YEARS LIVING RADIOISOTOPES</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoP4Vav4BzwsInhazedmcyyl2kLBSz0vaTZpI7ubJcmC_fembvHmYRhm3mdemBeAewRfMIH8lTBOGednYIIEKXNGIT0HEwgJyTkr-TW4CeELphkV4gpcFhhTRidgt9nrbGGMVjFzJpu7Ru2tsp3OXJfFpM2UGtqhkdGmRSKWh9q770PvXXOkZFcfyfXQ7dJx2zdWdiqtTdQ-W3kva_t7egsujGyCvjv1Kfh8W2zmy3z98b6az9a5IgTFXNcCp9IFLRXRiFBTS8SNJCXeImjolhcSCsIENiq9iJFQqKxLREqhlcGMTMHj6OtCtFVQNmq1V67r0oMVh5wVjCToeYSUdyF4bare21b6Q4VgdUyzOqWZyIeR7Idtq-s_bowvyU-j_BWi8_-6_AAgW3mW</recordid><startdate>19780101</startdate><enddate>19780101</enddate><creator>Dubrawsky, C.</creator><creator>Dubravsky, N. B.</creator><creator>Withers, H. R.</creator><general>Academic Press, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19780101</creationdate><title>The Effect of Colchicine on the Accumulation of Hydroxyproline and on Lung Compliance after Irradiation</title><author>Dubrawsky, C. ; Dubravsky, N. B. ; Withers, H. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-ed92ed9e648c3e134fda17fa382b10f4b76a093592fc540219c18d81389ecf253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>560152 - Radiation Effects on Animals- Animals</topic><topic>ALKALOIDS</topic><topic>ANIMALS</topic><topic>ANTIMITOTIC DRUGS</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BIOSYNTHESIS</topic><topic>BODY</topic><topic>BODY AREAS</topic><topic>CHEST</topic><topic>COBALT 60</topic><topic>COBALT ISOTOPES</topic><topic>COLCHICINE</topic><topic>Colchicine - administration & dosage</topic><topic>Colchicine - pharmacology</topic><topic>COLLAGEN</topic><topic>Collagen - metabolism</topic><topic>Collagens</topic><topic>DELAYED RADIATION EFFECTS</topic><topic>DISEASES</topic><topic>Dosage</topic><topic>Dose response relationship</topic><topic>Dose-Response Relationship, Drug</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>DRUGS</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>EXTERNAL IRRADIATION</topic><topic>FIBROSIS</topic><topic>GAMMA RADIATION</topic><topic>Hydroxyproline - metabolism</topic><topic>INHIBITION</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>INTERNAL CONVERSION RADIOISOTOPES</topic><topic>IONIZING RADIATIONS</topic><topic>IRRADIATION</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>Lung Compliance - radiation effects</topic><topic>LUNGS</topic><topic>Male</topic><topic>MAMMALS</topic><topic>MINUTES LIVING RADIOISOTOPES</topic><topic>NUCLEI</topic><topic>ODD-ODD NUCLEI</topic><topic>Organ Size</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANS</topic><topic>PARTIAL BODY IRRADIATION</topic><topic>PATHOLOGICAL CHANGES</topic><topic>PROTEINS</topic><topic>Pulmonary compliance</topic><topic>Pulmonary Fibrosis - etiology</topic><topic>Pulmonary Fibrosis - metabolism</topic><topic>Pulmonary Fibrosis - physiopathology</topic><topic>Radiation dosage</topic><topic>RADIATION EFFECTS</topic><topic>Radiation Injuries, Experimental - metabolism</topic><topic>Radiation Injuries, Experimental - physiopathology</topic><topic>Radiation pneumonitis</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIATIONS</topic><topic>RADIOINDUCTION</topic><topic>RADIOISOTOPES</topic><topic>RADIOSENSITIVITY EFFECTS</topic><topic>RATS</topic><topic>RESPIRATORY SYSTEM</topic><topic>RODENTS</topic><topic>SCLEROPROTEINS</topic><topic>Secretion</topic><topic>SYNTHESIS</topic><topic>TIME DEPENDENCE</topic><topic>Time Factors</topic><topic>VERTEBRATES</topic><topic>YEARS LIVING RADIOISOTOPES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dubrawsky, C.</creatorcontrib><creatorcontrib>Dubravsky, N. B.</creatorcontrib><creatorcontrib>Withers, H. R.</creatorcontrib><creatorcontrib>Univ. of Texas System Cancer Center, Houston</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Radiat. Res.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dubrawsky, C.</au><au>Dubravsky, N. B.</au><au>Withers, H. R.</au><aucorp>Univ. of Texas System Cancer Center, Houston</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Colchicine on the Accumulation of Hydroxyproline and on Lung Compliance after Irradiation</atitle><jtitle>Radiat. Res.; (United States)</jtitle><addtitle>Radiat Res</addtitle><date>1978-01-01</date><risdate>1978</risdate><volume>73</volume><issue>1</issue><spage>111</spage><epage>120</epage><pages>111-120</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>The development of late radiation fibrosis in rat lung after a single dose of 750, 1000, 1250, or 1500 rad of γ radiation was studied. The concentration of hydroxyproline was measured to evaluate collagen deposition in irradiated and control lungs. At 120 days after irradiation a linear dose-response curve can be established. Colchicine, known to modify collagen secretion and deposition, was used to modify lung fibrosis after irradiation. It was found that collagen deposition can be reduced only if colchicine is injected when the lung collagen is being synthesized, namely around 90 days after irradiation with these doses. Lung compliance at intervals up to 150 days after irradiation is reduced mainly as a result of increase in lung weight, not collagen deposition.</abstract><cop>United States</cop><pub>Academic Press, Inc</pub><pmid>622454</pmid><doi>10.2307/3574577</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0033-7587 |
| ispartof | Radiat. Res.; (United States), 1978-01, Vol.73 (1), p.111-120 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_crossref_primary_10_2307_3574577 |
| source | Jstor Complete Legacy; MEDLINE |
| subjects | 560152 - Radiation Effects on Animals- Animals ALKALOIDS ANIMALS ANTIMITOTIC DRUGS BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BIOSYNTHESIS BODY BODY AREAS CHEST COBALT 60 COBALT ISOTOPES COLCHICINE Colchicine - administration & dosage Colchicine - pharmacology COLLAGEN Collagen - metabolism Collagens DELAYED RADIATION EFFECTS DISEASES Dosage Dose response relationship Dose-Response Relationship, Drug DOSE-RESPONSE RELATIONSHIPS DRUGS ELECTROMAGNETIC RADIATION EXTERNAL IRRADIATION FIBROSIS GAMMA RADIATION Hydroxyproline - metabolism INHIBITION INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES IONIZING RADIATIONS IRRADIATION ISOMERIC TRANSITION ISOTOPES ISOTOPES Lung Compliance - radiation effects LUNGS Male MAMMALS MINUTES LIVING RADIOISOTOPES NUCLEI ODD-ODD NUCLEI Organ Size ORGANIC COMPOUNDS ORGANS PARTIAL BODY IRRADIATION PATHOLOGICAL CHANGES PROTEINS Pulmonary compliance Pulmonary Fibrosis - etiology Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - physiopathology Radiation dosage RADIATION EFFECTS Radiation Injuries, Experimental - metabolism Radiation Injuries, Experimental - physiopathology Radiation pneumonitis RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOINDUCTION RADIOISOTOPES RADIOSENSITIVITY EFFECTS RATS RESPIRATORY SYSTEM RODENTS SCLEROPROTEINS Secretion SYNTHESIS TIME DEPENDENCE Time Factors VERTEBRATES YEARS LIVING RADIOISOTOPES |
| title | The Effect of Colchicine on the Accumulation of Hydroxyproline and on Lung Compliance after Irradiation |
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