The Influence of Dose and Dose Rate on the Incidence of Neoplastic Disease in RFM Mice after Neutron Irradiation
The influence of dose and dose rate on tumorigenicity after neutron irradiation was investigated in female RFM mice exposed to various doses of neutrons at dose rates of 5 and 25 rad/min or 1 rad/day. Comparison of neutron irradiation with acute gamma irradiation showed that tumors were induced more...
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| Veröffentlicht in: | Radiat. Res.; (United States) 1976-10, Vol.68 (1), p.115-131 |
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| creator | Ullrich, R. L. Jernigan, M. C. Cosgrove, G. E. Satterfield, L. C. Bowles, N. D. Storer, J. B. |
| description | The influence of dose and dose rate on tumorigenicity after neutron irradiation was investigated in female RFM mice exposed to various doses of neutrons at dose rates of 5 and 25 rad/min or 1 rad/day. Comparison of neutron irradiation with acute gamma irradiation showed that tumors were induced more effectively with neutrons than with gamma rays, particularly at low doses. Linear relationships were obtained at both dose rates for thymic lymphoma induction after neutron irradiation, while a dose-squared relationship was obtained for gamma rays. At low doses little dose-rate dependence was seen with neutrons, while at the highest doses the low dose rate was more effective. An increased incidence of lung adenomas was seen after neutron irradiation with doses as low as 20 rad, while the incidence after gamma-ray irradiation decreased with increased dose except at approximately 300 rad. In spite of the apparent sensitivity, the neutron dose-response curve for lung tumors was not linear. Neutron irradiation at low dose rates appeared to induce thymic lymphomas and possibly lung adenomas more efficiently than irradiation at high dose rates, but was less effective than high dose rates in inducing ovarian and pituitary tumors. Both the importance of a more complete understanding of dose and dose-rate relationships (particularly in the low dose range) and the need for examination of the basis of such relationships are discussed. |
| doi_str_mv | 10.2307/3574539 |
| format | Article |
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L. ; Jernigan, M. C. ; Cosgrove, G. E. ; Satterfield, L. C. ; Bowles, N. D. ; Storer, J. B.</creator><creatorcontrib>Ullrich, R. L. ; Jernigan, M. C. ; Cosgrove, G. E. ; Satterfield, L. C. ; Bowles, N. D. ; Storer, J. B. ; Oak Ridge National Lab., TN</creatorcontrib><description>The influence of dose and dose rate on tumorigenicity after neutron irradiation was investigated in female RFM mice exposed to various doses of neutrons at dose rates of 5 and 25 rad/min or 1 rad/day. Comparison of neutron irradiation with acute gamma irradiation showed that tumors were induced more effectively with neutrons than with gamma rays, particularly at low doses. Linear relationships were obtained at both dose rates for thymic lymphoma induction after neutron irradiation, while a dose-squared relationship was obtained for gamma rays. At low doses little dose-rate dependence was seen with neutrons, while at the highest doses the low dose rate was more effective. An increased incidence of lung adenomas was seen after neutron irradiation with doses as low as 20 rad, while the incidence after gamma-ray irradiation decreased with increased dose except at approximately 300 rad. In spite of the apparent sensitivity, the neutron dose-response curve for lung tumors was not linear. Neutron irradiation at low dose rates appeared to induce thymic lymphomas and possibly lung adenomas more efficiently than irradiation at high dose rates, but was less effective than high dose rates in inducing ovarian and pituitary tumors. Both the importance of a more complete understanding of dose and dose-rate relationships (particularly in the low dose range) and the need for examination of the basis of such relationships are discussed.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3574539</identifier><identifier>PMID: 967967</identifier><language>eng</language><publisher>United States: Academic Press, Inc</publisher><subject>560152 - Radiation Effects on Animals- Animals ; ANIMALS ; BARYONS ; BODY ; Californium ; CARCINOGENESIS ; Cesium Radioisotopes ; DISEASES ; Dosage ; DOSE RATES ; Dose response relationship ; Dose-Response Relationship, Radiation ; ELEMENTARY PARTICLES ; Eye Neoplasms - etiology ; Female ; FERMIONS ; Gamma Rays ; HADRONS ; Harderian Gland ; IRRADIATION ; Leukemia, Radiation-Induced ; Lung Neoplasms - etiology ; LUNGS ; LYMPHATIC SYSTEM ; Lymphoma ; MAMMALS ; Mammary Neoplasms, Experimental - etiology ; MICE ; NEOPLASMS ; Neoplasms, Experimental - etiology ; Neoplasms, Radiation-Induced ; Neutron irradiation ; NEUTRONS ; NUCLEONS ; ORGANS ; Ovarian Neoplasms - etiology ; PATHOGENESIS ; Pituitary Neoplasms - etiology ; Radiation dose response relationship ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIOINDUCTION ; RADIOSENSITIVITY EFFECTS ; RESPIRATORY SYSTEM ; RODENTS ; THYMUS ; Tumors ; VERTEBRATES</subject><ispartof>Radiat. 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L.</creatorcontrib><creatorcontrib>Jernigan, M. C.</creatorcontrib><creatorcontrib>Cosgrove, G. E.</creatorcontrib><creatorcontrib>Satterfield, L. C.</creatorcontrib><creatorcontrib>Bowles, N. D.</creatorcontrib><creatorcontrib>Storer, J. B.</creatorcontrib><creatorcontrib>Oak Ridge National Lab., TN</creatorcontrib><title>The Influence of Dose and Dose Rate on the Incidence of Neoplastic Disease in RFM Mice after Neutron Irradiation</title><title>Radiat. Res.; (United States)</title><addtitle>Radiat Res</addtitle><description>The influence of dose and dose rate on tumorigenicity after neutron irradiation was investigated in female RFM mice exposed to various doses of neutrons at dose rates of 5 and 25 rad/min or 1 rad/day. Comparison of neutron irradiation with acute gamma irradiation showed that tumors were induced more effectively with neutrons than with gamma rays, particularly at low doses. Linear relationships were obtained at both dose rates for thymic lymphoma induction after neutron irradiation, while a dose-squared relationship was obtained for gamma rays. At low doses little dose-rate dependence was seen with neutrons, while at the highest doses the low dose rate was more effective. An increased incidence of lung adenomas was seen after neutron irradiation with doses as low as 20 rad, while the incidence after gamma-ray irradiation decreased with increased dose except at approximately 300 rad. In spite of the apparent sensitivity, the neutron dose-response curve for lung tumors was not linear. Neutron irradiation at low dose rates appeared to induce thymic lymphomas and possibly lung adenomas more efficiently than irradiation at high dose rates, but was less effective than high dose rates in inducing ovarian and pituitary tumors. Both the importance of a more complete understanding of dose and dose-rate relationships (particularly in the low dose range) and the need for examination of the basis of such relationships are discussed.</description><subject>560152 - Radiation Effects on Animals- Animals</subject><subject>ANIMALS</subject><subject>BARYONS</subject><subject>BODY</subject><subject>Californium</subject><subject>CARCINOGENESIS</subject><subject>Cesium Radioisotopes</subject><subject>DISEASES</subject><subject>Dosage</subject><subject>DOSE RATES</subject><subject>Dose response relationship</subject><subject>Dose-Response Relationship, Radiation</subject><subject>ELEMENTARY PARTICLES</subject><subject>Eye Neoplasms - etiology</subject><subject>Female</subject><subject>FERMIONS</subject><subject>Gamma Rays</subject><subject>HADRONS</subject><subject>Harderian Gland</subject><subject>IRRADIATION</subject><subject>Leukemia, Radiation-Induced</subject><subject>Lung Neoplasms - etiology</subject><subject>LUNGS</subject><subject>LYMPHATIC SYSTEM</subject><subject>Lymphoma</subject><subject>MAMMALS</subject><subject>Mammary Neoplasms, Experimental - etiology</subject><subject>MICE</subject><subject>NEOPLASMS</subject><subject>Neoplasms, Experimental - etiology</subject><subject>Neoplasms, Radiation-Induced</subject><subject>Neutron irradiation</subject><subject>NEUTRONS</subject><subject>NUCLEONS</subject><subject>ORGANS</subject><subject>Ovarian Neoplasms - etiology</subject><subject>PATHOGENESIS</subject><subject>Pituitary Neoplasms - etiology</subject><subject>Radiation dose response relationship</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOINDUCTION</subject><subject>RADIOSENSITIVITY EFFECTS</subject><subject>RESPIRATORY SYSTEM</subject><subject>RODENTS</subject><subject>THYMUS</subject><subject>Tumors</subject><subject>VERTEBRATES</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtKAzEUBuAg3moVX8BFEMHVaGYyk0yW0lottAqlroc0c0JT2mRI0oVvb3SqOyGQy_nOIfwIXefkoaCEP9KKlxUVR2iQC1pnVUnKYzQghNKMVzU_RxchbEi650ycoVPBeFoD1C3XgKdWb_dgFWCn8dgFwNK2_WEhY3q1OP4wZdpf9gau28oQjcJjE0AmayxeTOZ4bpKQOoJPaB996p56L1sjo3H2Ep1ouQ1wddiH6GPyvBy9ZrP3l-noaZYpKnjMWi5rCoLrShQtqEJTKBUTGsq8JJXmLV_Vikiu-UqQnAADLqiuqdSSacEYHaLbfq5Lf2yCMhHUWjlrQcWGU0qKlMUQ3fdIeReCB9103uyk_2xy0nzH2hxiTfKml91-tYP2z_U5pvJdX96E6Py_U74A2Np8Hg</recordid><startdate>197610</startdate><enddate>197610</enddate><creator>Ullrich, R. L.</creator><creator>Jernigan, M. C.</creator><creator>Cosgrove, G. E.</creator><creator>Satterfield, L. C.</creator><creator>Bowles, N. D.</creator><creator>Storer, J. B.</creator><general>Academic Press, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>197610</creationdate><title>The Influence of Dose and Dose Rate on the Incidence of Neoplastic Disease in RFM Mice after Neutron Irradiation</title><author>Ullrich, R. L. ; Jernigan, M. C. ; Cosgrove, G. E. ; Satterfield, L. C. ; Bowles, N. D. ; Storer, J. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-d7a83e97f592dec2f3e4c69fe41405f7d7b8c0a7f7b9010e6e793f83afa6f9663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>560152 - Radiation Effects on Animals- Animals</topic><topic>ANIMALS</topic><topic>BARYONS</topic><topic>BODY</topic><topic>Californium</topic><topic>CARCINOGENESIS</topic><topic>Cesium Radioisotopes</topic><topic>DISEASES</topic><topic>Dosage</topic><topic>DOSE RATES</topic><topic>Dose response relationship</topic><topic>Dose-Response Relationship, Radiation</topic><topic>ELEMENTARY PARTICLES</topic><topic>Eye Neoplasms - etiology</topic><topic>Female</topic><topic>FERMIONS</topic><topic>Gamma Rays</topic><topic>HADRONS</topic><topic>Harderian Gland</topic><topic>IRRADIATION</topic><topic>Leukemia, Radiation-Induced</topic><topic>Lung Neoplasms - etiology</topic><topic>LUNGS</topic><topic>LYMPHATIC SYSTEM</topic><topic>Lymphoma</topic><topic>MAMMALS</topic><topic>Mammary Neoplasms, Experimental - etiology</topic><topic>MICE</topic><topic>NEOPLASMS</topic><topic>Neoplasms, Experimental - etiology</topic><topic>Neoplasms, Radiation-Induced</topic><topic>Neutron irradiation</topic><topic>NEUTRONS</topic><topic>NUCLEONS</topic><topic>ORGANS</topic><topic>Ovarian Neoplasms - etiology</topic><topic>PATHOGENESIS</topic><topic>Pituitary Neoplasms - etiology</topic><topic>Radiation dose response relationship</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOINDUCTION</topic><topic>RADIOSENSITIVITY EFFECTS</topic><topic>RESPIRATORY SYSTEM</topic><topic>RODENTS</topic><topic>THYMUS</topic><topic>Tumors</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ullrich, R. L.</creatorcontrib><creatorcontrib>Jernigan, M. C.</creatorcontrib><creatorcontrib>Cosgrove, G. E.</creatorcontrib><creatorcontrib>Satterfield, L. C.</creatorcontrib><creatorcontrib>Bowles, N. D.</creatorcontrib><creatorcontrib>Storer, J. B.</creatorcontrib><creatorcontrib>Oak Ridge National Lab., TN</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Radiat. Res.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ullrich, R. L.</au><au>Jernigan, M. C.</au><au>Cosgrove, G. E.</au><au>Satterfield, L. C.</au><au>Bowles, N. D.</au><au>Storer, J. B.</au><aucorp>Oak Ridge National Lab., TN</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Influence of Dose and Dose Rate on the Incidence of Neoplastic Disease in RFM Mice after Neutron Irradiation</atitle><jtitle>Radiat. Res.; (United States)</jtitle><addtitle>Radiat Res</addtitle><date>1976-10</date><risdate>1976</risdate><volume>68</volume><issue>1</issue><spage>115</spage><epage>131</epage><pages>115-131</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>The influence of dose and dose rate on tumorigenicity after neutron irradiation was investigated in female RFM mice exposed to various doses of neutrons at dose rates of 5 and 25 rad/min or 1 rad/day. Comparison of neutron irradiation with acute gamma irradiation showed that tumors were induced more effectively with neutrons than with gamma rays, particularly at low doses. Linear relationships were obtained at both dose rates for thymic lymphoma induction after neutron irradiation, while a dose-squared relationship was obtained for gamma rays. At low doses little dose-rate dependence was seen with neutrons, while at the highest doses the low dose rate was more effective. An increased incidence of lung adenomas was seen after neutron irradiation with doses as low as 20 rad, while the incidence after gamma-ray irradiation decreased with increased dose except at approximately 300 rad. In spite of the apparent sensitivity, the neutron dose-response curve for lung tumors was not linear. Neutron irradiation at low dose rates appeared to induce thymic lymphomas and possibly lung adenomas more efficiently than irradiation at high dose rates, but was less effective than high dose rates in inducing ovarian and pituitary tumors. Both the importance of a more complete understanding of dose and dose-rate relationships (particularly in the low dose range) and the need for examination of the basis of such relationships are discussed.</abstract><cop>United States</cop><pub>Academic Press, Inc</pub><pmid>967967</pmid><doi>10.2307/3574539</doi><tpages>17</tpages></addata></record> |
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| identifier | ISSN: 0033-7587 |
| ispartof | Radiat. Res.; (United States), 1976-10, Vol.68 (1), p.115-131 |
| issn | 0033-7587 1938-5404 |
| language | eng |
| recordid | cdi_crossref_primary_10_2307_3574539 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | 560152 - Radiation Effects on Animals- Animals ANIMALS BARYONS BODY Californium CARCINOGENESIS Cesium Radioisotopes DISEASES Dosage DOSE RATES Dose response relationship Dose-Response Relationship, Radiation ELEMENTARY PARTICLES Eye Neoplasms - etiology Female FERMIONS Gamma Rays HADRONS Harderian Gland IRRADIATION Leukemia, Radiation-Induced Lung Neoplasms - etiology LUNGS LYMPHATIC SYSTEM Lymphoma MAMMALS Mammary Neoplasms, Experimental - etiology MICE NEOPLASMS Neoplasms, Experimental - etiology Neoplasms, Radiation-Induced Neutron irradiation NEUTRONS NUCLEONS ORGANS Ovarian Neoplasms - etiology PATHOGENESIS Pituitary Neoplasms - etiology Radiation dose response relationship RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOINDUCTION RADIOSENSITIVITY EFFECTS RESPIRATORY SYSTEM RODENTS THYMUS Tumors VERTEBRATES |
| title | The Influence of Dose and Dose Rate on the Incidence of Neoplastic Disease in RFM Mice after Neutron Irradiation |
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