Radical Oxidation Mechanisms in Cellular Radiosensitisation: Electron Transfer in the Pulse Radiolysis of Aqueous Nucleotide Solutions
Pulse radiolysis has been used to study one-electron transfer reactions in aqueous solutions containing various nucleic acid derivatives and, also, in solutions containing some highly electron-affinic compounds which can function as cellular radiosensitisers. These include 2 methyl naphthaquinone an...
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| Veröffentlicht in: | Radiat. Res. 49: No. 1, 85-95(Jan 1972) 85-95(Jan 1972), 1972-01, Vol.49 (1), p.85-95 |
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| container_title | Radiat. Res. 49: No. 1, 85-95(Jan 1972) |
| container_volume | 49 |
| creator | Adams, G. E. Greenstock, C. L. Van Hemmen, J. J. Willson, R. L. |
| description | Pulse radiolysis has been used to study one-electron transfer reactions in aqueous solutions containing various nucleic acid derivatives and, also, in solutions containing some highly electron-affinic compounds which can function as cellular radiosensitisers. These include 2 methyl naphthaquinone and paranitroacetophenone (PNAP). Radicals derived from nucleic acid derivatives transfer electrons to the sensitisers at rates which approach diffusion-limited values. The electron affinity of the substituted pyrimidine, orotic acid (OA) is intermediate between those of the common nucleic acid derivatives and those of the radiosensitisers. This, together with the intense absorption spectrum of its electron adduct, makes it a useful marker for these studies. The relevance of these model studies in aqueous solution to mechanisms of radiosensitisation, are discussed. |
| doi_str_mv | 10.2307/3573374 |
| format | Article |
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E. ; Greenstock, C. L. ; Van Hemmen, J. J. ; Willson, R. L.</creator><creatorcontrib>Adams, G. E. ; Greenstock, C. L. ; Van Hemmen, J. J. ; Willson, R. L. ; Mount Vernon Hospital, Middlesex, Eng</creatorcontrib><description>Pulse radiolysis has been used to study one-electron transfer reactions in aqueous solutions containing various nucleic acid derivatives and, also, in solutions containing some highly electron-affinic compounds which can function as cellular radiosensitisers. These include 2 methyl naphthaquinone and paranitroacetophenone (PNAP). Radicals derived from nucleic acid derivatives transfer electrons to the sensitisers at rates which approach diffusion-limited values. The electron affinity of the substituted pyrimidine, orotic acid (OA) is intermediate between those of the common nucleic acid derivatives and those of the radiosensitisers. This, together with the intense absorption spectrum of its electron adduct, makes it a useful marker for these studies. The relevance of these model studies in aqueous solution to mechanisms of radiosensitisation, are discussed.</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.2307/3573374</identifier><identifier>PMID: 5009151</identifier><language>eng</language><publisher>United States: Academic Press, Inc</publisher><subject>Absorption spectra ; Acetophenones - radiation effects ; Acids ; Adducts ; Aqueous solutions ; Benzophenones - radiation effects ; Electron transfer ; Electron Transport ; ELECTRONS ; ELECTRONS/reactions with nucleotides in aqueous solutions during pulse radiolysis, relation to radiosensitization mechanisms ; Free Radicals ; Kinetics ; Models, Biological ; N48110 -Life Sciences-Radiation Effects on Biochemicals- In-Vitro ; Naphthoquinones - radiation effects ; Nucleic acids ; NUCLEOTIDES ; Nucleotides - radiation effects ; NUCLEOTIDES/radiolysis of aqueous solutions of, relation of electron transfer reactions in pulse, to radiosensitization mechanisms ; Orotic Acid - radiation effects ; Oxidation-Reduction ; Radiation Effects ; Radiation-Sensitizing Agents ; Radiochemistry ; RADIOLYSIS ; RADIOSENSITIVITY ; Sensitization ; SOLUTIONS ; Spectrum Analysis ; Thymine - radiation effects ; TRANSFER REACTIONS ; Water</subject><ispartof>Radiat. Res. 49: No. 1, 85-95(Jan 1972), 1972-01, Vol.49 (1), p.85-95</ispartof><rights>Copyright 1972 Academic Press, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c247t-86df967b6a610022baee1dd4d59ad5dc64cf218da95d27e6df5ba58f3a076ffb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3573374$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3573374$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,885,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5009151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/4689388$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Adams, G. E.</creatorcontrib><creatorcontrib>Greenstock, C. L.</creatorcontrib><creatorcontrib>Van Hemmen, J. J.</creatorcontrib><creatorcontrib>Willson, R. L.</creatorcontrib><creatorcontrib>Mount Vernon Hospital, Middlesex, Eng</creatorcontrib><title>Radical Oxidation Mechanisms in Cellular Radiosensitisation: Electron Transfer in the Pulse Radiolysis of Aqueous Nucleotide Solutions</title><title>Radiat. Res. 49: No. 1, 85-95(Jan 1972)</title><addtitle>Radiat Res</addtitle><description>Pulse radiolysis has been used to study one-electron transfer reactions in aqueous solutions containing various nucleic acid derivatives and, also, in solutions containing some highly electron-affinic compounds which can function as cellular radiosensitisers. These include 2 methyl naphthaquinone and paranitroacetophenone (PNAP). Radicals derived from nucleic acid derivatives transfer electrons to the sensitisers at rates which approach diffusion-limited values. The electron affinity of the substituted pyrimidine, orotic acid (OA) is intermediate between those of the common nucleic acid derivatives and those of the radiosensitisers. This, together with the intense absorption spectrum of its electron adduct, makes it a useful marker for these studies. The relevance of these model studies in aqueous solution to mechanisms of radiosensitisation, are discussed.</description><subject>Absorption spectra</subject><subject>Acetophenones - radiation effects</subject><subject>Acids</subject><subject>Adducts</subject><subject>Aqueous solutions</subject><subject>Benzophenones - radiation effects</subject><subject>Electron transfer</subject><subject>Electron Transport</subject><subject>ELECTRONS</subject><subject>ELECTRONS/reactions with nucleotides in aqueous solutions during pulse radiolysis, relation to radiosensitization mechanisms</subject><subject>Free Radicals</subject><subject>Kinetics</subject><subject>Models, Biological</subject><subject>N48110 -Life Sciences-Radiation Effects on Biochemicals- In-Vitro</subject><subject>Naphthoquinones - radiation effects</subject><subject>Nucleic acids</subject><subject>NUCLEOTIDES</subject><subject>Nucleotides - radiation effects</subject><subject>NUCLEOTIDES/radiolysis of aqueous solutions of, relation of electron transfer reactions in pulse, to radiosensitization mechanisms</subject><subject>Orotic Acid - radiation effects</subject><subject>Oxidation-Reduction</subject><subject>Radiation Effects</subject><subject>Radiation-Sensitizing Agents</subject><subject>Radiochemistry</subject><subject>RADIOLYSIS</subject><subject>RADIOSENSITIVITY</subject><subject>Sensitization</subject><subject>SOLUTIONS</subject><subject>Spectrum Analysis</subject><subject>Thymine - radiation effects</subject><subject>TRANSFER REACTIONS</subject><subject>Water</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF9LHDEUxUOp6Lot_QSFUIQ-jSaTyWTGN1m2Kqxuae3zkMkfjGQna24G3C_g527WWXzz6XI5v3PgHIS-UXJeMiIuGBeMieoTmtGWNQWvSPUZzQhhrBC8ESfoFOCJ5J_W7TE65oS0lNMZev0jtVPS4_WL0zK5MOA7ox7l4GAD2A14YbwfvYx4DwYwA7jk4I28xEtvVIrZ8xDlANbEvSM9Gvx79GAmi9-BAxwsvnoeTRgB34_Km5CcNvhv8OM-Cb6gIyuz5evhztG_X8uHxU2xWl_fLq5WhSorkYqm1ratRV_LmhJSlr00hmpdad5KzbWqK2VL2mjZcl0Kk2neS95YJomore3ZHP2YcgMk14FyKZdVYRhyj66qm7xdk6GfE6RiAIjGdtvoNjLuOkq6_drdYe1Mfp_I7dhvjH7nDvNm_WzSnyCF-GHMf0oxh9w</recordid><startdate>19720101</startdate><enddate>19720101</enddate><creator>Adams, G. E.</creator><creator>Greenstock, C. L.</creator><creator>Van Hemmen, J. J.</creator><creator>Willson, R. L.</creator><general>Academic Press, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>19720101</creationdate><title>Radical Oxidation Mechanisms in Cellular Radiosensitisation: Electron Transfer in the Pulse Radiolysis of Aqueous Nucleotide Solutions</title><author>Adams, G. E. ; Greenstock, C. L. ; Van Hemmen, J. J. ; Willson, R. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c247t-86df967b6a610022baee1dd4d59ad5dc64cf218da95d27e6df5ba58f3a076ffb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Absorption spectra</topic><topic>Acetophenones - radiation effects</topic><topic>Acids</topic><topic>Adducts</topic><topic>Aqueous solutions</topic><topic>Benzophenones - radiation effects</topic><topic>Electron transfer</topic><topic>Electron Transport</topic><topic>ELECTRONS</topic><topic>ELECTRONS/reactions with nucleotides in aqueous solutions during pulse radiolysis, relation to radiosensitization mechanisms</topic><topic>Free Radicals</topic><topic>Kinetics</topic><topic>Models, Biological</topic><topic>N48110 -Life Sciences-Radiation Effects on Biochemicals- In-Vitro</topic><topic>Naphthoquinones - radiation effects</topic><topic>Nucleic acids</topic><topic>NUCLEOTIDES</topic><topic>Nucleotides - radiation effects</topic><topic>NUCLEOTIDES/radiolysis of aqueous solutions of, relation of electron transfer reactions in pulse, to radiosensitization mechanisms</topic><topic>Orotic Acid - radiation effects</topic><topic>Oxidation-Reduction</topic><topic>Radiation Effects</topic><topic>Radiation-Sensitizing Agents</topic><topic>Radiochemistry</topic><topic>RADIOLYSIS</topic><topic>RADIOSENSITIVITY</topic><topic>Sensitization</topic><topic>SOLUTIONS</topic><topic>Spectrum Analysis</topic><topic>Thymine - radiation effects</topic><topic>TRANSFER REACTIONS</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adams, G. E.</creatorcontrib><creatorcontrib>Greenstock, C. L.</creatorcontrib><creatorcontrib>Van Hemmen, J. J.</creatorcontrib><creatorcontrib>Willson, R. L.</creatorcontrib><creatorcontrib>Mount Vernon Hospital, Middlesex, Eng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Radiat. Res. 49: No. 1, 85-95(Jan 1972)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adams, G. E.</au><au>Greenstock, C. L.</au><au>Van Hemmen, J. J.</au><au>Willson, R. L.</au><aucorp>Mount Vernon Hospital, Middlesex, Eng</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radical Oxidation Mechanisms in Cellular Radiosensitisation: Electron Transfer in the Pulse Radiolysis of Aqueous Nucleotide Solutions</atitle><jtitle>Radiat. Res. 49: No. 1, 85-95(Jan 1972)</jtitle><addtitle>Radiat Res</addtitle><date>1972-01-01</date><risdate>1972</risdate><volume>49</volume><issue>1</issue><spage>85</spage><epage>95</epage><pages>85-95</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>Pulse radiolysis has been used to study one-electron transfer reactions in aqueous solutions containing various nucleic acid derivatives and, also, in solutions containing some highly electron-affinic compounds which can function as cellular radiosensitisers. These include 2 methyl naphthaquinone and paranitroacetophenone (PNAP). Radicals derived from nucleic acid derivatives transfer electrons to the sensitisers at rates which approach diffusion-limited values. The electron affinity of the substituted pyrimidine, orotic acid (OA) is intermediate between those of the common nucleic acid derivatives and those of the radiosensitisers. This, together with the intense absorption spectrum of its electron adduct, makes it a useful marker for these studies. The relevance of these model studies in aqueous solution to mechanisms of radiosensitisation, are discussed.</abstract><cop>United States</cop><pub>Academic Press, Inc</pub><pmid>5009151</pmid><doi>10.2307/3573374</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-7587 |
| ispartof | Radiat. Res. 49: No. 1, 85-95(Jan 1972), 1972-01, Vol.49 (1), p.85-95 |
| issn | 0033-7587 1938-5404 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Absorption spectra Acetophenones - radiation effects Acids Adducts Aqueous solutions Benzophenones - radiation effects Electron transfer Electron Transport ELECTRONS ELECTRONS/reactions with nucleotides in aqueous solutions during pulse radiolysis, relation to radiosensitization mechanisms Free Radicals Kinetics Models, Biological N48110 -Life Sciences-Radiation Effects on Biochemicals- In-Vitro Naphthoquinones - radiation effects Nucleic acids NUCLEOTIDES Nucleotides - radiation effects NUCLEOTIDES/radiolysis of aqueous solutions of, relation of electron transfer reactions in pulse, to radiosensitization mechanisms Orotic Acid - radiation effects Oxidation-Reduction Radiation Effects Radiation-Sensitizing Agents Radiochemistry RADIOLYSIS RADIOSENSITIVITY Sensitization SOLUTIONS Spectrum Analysis Thymine - radiation effects TRANSFER REACTIONS Water |
| title | Radical Oxidation Mechanisms in Cellular Radiosensitisation: Electron Transfer in the Pulse Radiolysis of Aqueous Nucleotide Solutions |
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