Maximum Likelihood Estimation for Cytogenetic Dose-Response Curves

In vitro dose-response curves are used to describe the relation between chromosome aberrations and radiation dose for human lymphocytes. The lymphocytes are exposed to low-LET radiation, and the resulting dicentric chromosome aberrations follow the Poisson distribution. The expected yield depends on...

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Bibliographische Detailangaben
Veröffentlicht in:	Biometrics 1986-03, Vol.42 (1), p.73-84
Hauptverfasser:	Frome, E. L., DuFrain, R. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	560121 - Radiation Effects on Cells- External Source- (-1987) ANIMAL CELLS Biological and medical sciences BIOLOGICAL EFFECTS Biological effects of radiation BIOLOGICAL MATERIALS BIOLOGICAL RADIATION EFFECTS Biometrics BLOOD BLOOD CELLS BODY FLUIDS CHROMOSOMAL ABERRATIONS Chromosome Aberrations CONNECTIVE TISSUE CELLS Cytogenetics Dose response relationship Dose-Response Relationship, Radiation DOSE-RESPONSE RELATIONSHIPS DOSES ENERGY TRANSFER Fundamental and applied biological sciences. Psychology GENETIC EFFECTS GENETIC RADIATION EFFECTS Humans LET LEUKOCYTES Linear regression LYMPHOCYTES Lymphocytes - radiation effects MATERIALS Models, Genetic MUTATIONS Parametric models PROBABILITY Radiation dosage Radiation dose response relationship RADIATION DOSES RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Regression analysis Research Design SOMATIC CELLS Tissues, organs and organisms biophysics
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