TNF-α -308G/A polymorphism and susceptibility to tuberculosis in Azeri population of Iran
Single nucleotide polymorphisms (SNPs) in cytokine genes may alter the level and function of secreted cytokine; therefore, SNPs can influence the immune response. The aim of the present study was to determine the association of TNF-? -308G/A single nucleotide polymorphism in tuberculosis patients in...
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| Veröffentlicht in: | Genetika (Beograd) 2016, Vol.48 (3), p.819-826 |
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| creator | Ghorghanlu, Sajjad Asgharzadeh, Mohammad Samadi-Kafil, Hossein Khaki-Khatibi, Fatemeh Rashedi, Jalil Mahdavi, Poor Moaddab, Seyyed Pourostadi, Mahya |
| description | Single nucleotide polymorphisms (SNPs) in cytokine genes may alter the level
and function of secreted cytokine; therefore, SNPs can influence the immune
response. The aim of the present study was to determine the association of
TNF-? -308G/A single nucleotide polymorphism in tuberculosis patients in the
Azeri population of Iran. The TNF-308G/A single nucleotide polymorphism in
the promoter region was genotyped by using the allele-specific PCR method in
200 healthy controls and 124 tuberculosis patients. The distribution of
allele frequencies for TNF-? -308G/A polymorphism between control and
tuberculosis patient groups was not significant (P-value = 0.058, OR = 1.5).
Furthermore, no statistically significant association was found between TNF-?
-308G/A genotype and resistance/susceptibility to TB (P-value = 0.102). Our
results suggest that TNF-? -308G/A polymorphism has no measurable effect on
the development of tuberculosis in Azeri population of Iran.
nema |
| doi_str_mv | 10.2298/GENSR1603819G |
| format | Article |
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and function of secreted cytokine; therefore, SNPs can influence the immune
response. The aim of the present study was to determine the association of
TNF-? -308G/A single nucleotide polymorphism in tuberculosis patients in the
Azeri population of Iran. The TNF-308G/A single nucleotide polymorphism in
the promoter region was genotyped by using the allele-specific PCR method in
200 healthy controls and 124 tuberculosis patients. The distribution of
allele frequencies for TNF-? -308G/A polymorphism between control and
tuberculosis patient groups was not significant (P-value = 0.058, OR = 1.5).
Furthermore, no statistically significant association was found between TNF-?
-308G/A genotype and resistance/susceptibility to TB (P-value = 0.102). Our
results suggest that TNF-? -308G/A polymorphism has no measurable effect on
the development of tuberculosis in Azeri population of Iran.
nema</description><identifier>ISSN: 0534-0012</identifier><identifier>EISSN: 1820-6069</identifier><identifier>DOI: 10.2298/GENSR1603819G</identifier><language>eng</language><ispartof>Genetika (Beograd), 2016, Vol.48 (3), p.819-826</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c121g-59ee4c3e7044bbac7b7ff8a047869ada63235e6a306427506229ccfece9571073</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids></links><search><creatorcontrib>Ghorghanlu, Sajjad</creatorcontrib><creatorcontrib>Asgharzadeh, Mohammad</creatorcontrib><creatorcontrib>Samadi-Kafil, Hossein</creatorcontrib><creatorcontrib>Khaki-Khatibi, Fatemeh</creatorcontrib><creatorcontrib>Rashedi, Jalil</creatorcontrib><creatorcontrib>Mahdavi, Poor</creatorcontrib><creatorcontrib>Moaddab, Seyyed</creatorcontrib><creatorcontrib>Pourostadi, Mahya</creatorcontrib><title>TNF-α -308G/A polymorphism and susceptibility to tuberculosis in Azeri population of Iran</title><title>Genetika (Beograd)</title><description>Single nucleotide polymorphisms (SNPs) in cytokine genes may alter the level
and function of secreted cytokine; therefore, SNPs can influence the immune
response. The aim of the present study was to determine the association of
TNF-? -308G/A single nucleotide polymorphism in tuberculosis patients in the
Azeri population of Iran. The TNF-308G/A single nucleotide polymorphism in
the promoter region was genotyped by using the allele-specific PCR method in
200 healthy controls and 124 tuberculosis patients. The distribution of
allele frequencies for TNF-? -308G/A polymorphism between control and
tuberculosis patient groups was not significant (P-value = 0.058, OR = 1.5).
Furthermore, no statistically significant association was found between TNF-?
-308G/A genotype and resistance/susceptibility to TB (P-value = 0.102). Our
results suggest that TNF-? -308G/A polymorphism has no measurable effect on
the development of tuberculosis in Azeri population of Iran.
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and function of secreted cytokine; therefore, SNPs can influence the immune
response. The aim of the present study was to determine the association of
TNF-? -308G/A single nucleotide polymorphism in tuberculosis patients in the
Azeri population of Iran. The TNF-308G/A single nucleotide polymorphism in
the promoter region was genotyped by using the allele-specific PCR method in
200 healthy controls and 124 tuberculosis patients. The distribution of
allele frequencies for TNF-? -308G/A polymorphism between control and
tuberculosis patient groups was not significant (P-value = 0.058, OR = 1.5).
Furthermore, no statistically significant association was found between TNF-?
-308G/A genotype and resistance/susceptibility to TB (P-value = 0.102). Our
results suggest that TNF-? -308G/A polymorphism has no measurable effect on
the development of tuberculosis in Azeri population of Iran.
nema</abstract><doi>10.2298/GENSR1603819G</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| title | TNF-α -308G/A polymorphism and susceptibility to tuberculosis in Azeri population of Iran |
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