Modulation of nickel-induced bursting with 4-aminopyridine in leech retzius nerve cells
Paroxysmal depolarization shift has been identified as a characteristic feature of the cellular basis of epilepsy. On Na+-dependent bursting, 1 mmol/l 4-aminopyridine (4-AP) produced a two-phase effect - a significant depolarization accompanied by an increase in the frequency of bursting, followed b...
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| Veröffentlicht in: | Archives of biological sciences 2010, Vol.62 (4), p.1035-1045 |
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| creator | Pathak, Dhruba Lopicic, S. Bratic-Stanojevic, Marija Pavlovic, D. Andjus, P.R. Nedeljkov, V. |
| description | Paroxysmal depolarization shift has been identified as a characteristic
feature of the cellular basis of epilepsy. On Na+-dependent bursting, 1
mmol/l 4-aminopyridine (4-AP) produced a two-phase effect - a significant
depolarization accompanied by an increase in the frequency of bursting,
followed by repolarization along with a diminished frequency of bursting.
Neither 1 ?mol/l apamin nor 150 nmol/l charybdotoxin (ChTX) elicited any
significant effect on either bursting or standard conditions. Our results
suggest that 4-AP affects the bursting indirectly by altering the
excitability of the cell. The lack of effects of apamin and ChTX is probably
due to channel insensitivity to these blockers in leech.
nema
PR Projekat Ministarstva nauke Republike Srbije, br. 143054 |
| doi_str_mv | 10.2298/ABS1004035P |
| format | Article |
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feature of the cellular basis of epilepsy. On Na+-dependent bursting, 1
mmol/l 4-aminopyridine (4-AP) produced a two-phase effect - a significant
depolarization accompanied by an increase in the frequency of bursting,
followed by repolarization along with a diminished frequency of bursting.
Neither 1 ?mol/l apamin nor 150 nmol/l charybdotoxin (ChTX) elicited any
significant effect on either bursting or standard conditions. Our results
suggest that 4-AP affects the bursting indirectly by altering the
excitability of the cell. The lack of effects of apamin and ChTX is probably
due to channel insensitivity to these blockers in leech.
nema
PR Projekat Ministarstva nauke Republike Srbije, br. 143054</description><identifier>ISSN: 0354-4664</identifier><identifier>EISSN: 1821-4339</identifier><identifier>DOI: 10.2298/ABS1004035P</identifier><language>eng</language><ispartof>Archives of biological sciences, 2010, Vol.62 (4), p.1035-1045</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c270t-232c8ab319b171dacde0e8e0d508b238b536d3cfbc1a4151857658bc5adb8dc43</citedby><cites>FETCH-LOGICAL-c270t-232c8ab319b171dacde0e8e0d508b238b536d3cfbc1a4151857658bc5adb8dc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>Pathak, Dhruba</creatorcontrib><creatorcontrib>Lopicic, S.</creatorcontrib><creatorcontrib>Bratic-Stanojevic, Marija</creatorcontrib><creatorcontrib>Pavlovic, D.</creatorcontrib><creatorcontrib>Andjus, P.R.</creatorcontrib><creatorcontrib>Nedeljkov, V.</creatorcontrib><title>Modulation of nickel-induced bursting with 4-aminopyridine in leech retzius nerve cells</title><title>Archives of biological sciences</title><description>Paroxysmal depolarization shift has been identified as a characteristic
feature of the cellular basis of epilepsy. On Na+-dependent bursting, 1
mmol/l 4-aminopyridine (4-AP) produced a two-phase effect - a significant
depolarization accompanied by an increase in the frequency of bursting,
followed by repolarization along with a diminished frequency of bursting.
Neither 1 ?mol/l apamin nor 150 nmol/l charybdotoxin (ChTX) elicited any
significant effect on either bursting or standard conditions. Our results
suggest that 4-AP affects the bursting indirectly by altering the
excitability of the cell. The lack of effects of apamin and ChTX is probably
due to channel insensitivity to these blockers in leech.
nema
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feature of the cellular basis of epilepsy. On Na+-dependent bursting, 1
mmol/l 4-aminopyridine (4-AP) produced a two-phase effect - a significant
depolarization accompanied by an increase in the frequency of bursting,
followed by repolarization along with a diminished frequency of bursting.
Neither 1 ?mol/l apamin nor 150 nmol/l charybdotoxin (ChTX) elicited any
significant effect on either bursting or standard conditions. Our results
suggest that 4-AP affects the bursting indirectly by altering the
excitability of the cell. The lack of effects of apamin and ChTX is probably
due to channel insensitivity to these blockers in leech.
nema
PR Projekat Ministarstva nauke Republike Srbije, br. 143054</abstract><doi>10.2298/ABS1004035P</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of biological sciences, 2010, Vol.62 (4), p.1035-1045 |
| issn | 0354-4664 1821-4339 |
| language | eng |
| recordid | cdi_crossref_primary_10_2298_ABS1004035P |
| source | DOAJ Directory of Open Access Journals |
| title | Modulation of nickel-induced bursting with 4-aminopyridine in leech retzius nerve cells |
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