FORMULATION AND IN-VITRO EVALUATION OF FLOATING PULSATILE DRUG DELIVERY SYSTEM OF IVABRADINE

The aim of present investigation was to develop press coated tablets for Floating pulsatile drug delivery of Ivabradine used for is a medication used for the symptomatic management of stable heart-related chest pain and heart failure not fully managed by beta blockers. The drug delivery system was designed to deliver the drug such a time when it could be needful of patient conditions. The press coated tablets containing Ivabradine in the inner core were formulated by direct compression method with an outer coating of different amount of HPMCK200 M. The release profile of press coated tablet exhibited a lag time. The optimized batch F9 gave good drug release of 99.58 %. Key words: Ivabradine, Eudragit, EC, HPMCK200M