GASTROPROTECTIVE NSAIDs
NSAIDs suffer from a serious drawback of GI-SEs caused particularly after chronic use. There is evidence concerning the participation of ROS in the etiology & pathophysiology of digestive system disorders like GI-inflammation & gastro ulcer. With the aim to retard the adverse effects of GI-O...
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| Veröffentlicht in: | Journal of drug delivery and therapeutics 2018-09, Vol.8 (5), p.141-145 |
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| container_issue | 5 |
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| container_title | Journal of drug delivery and therapeutics |
| container_volume | 8 |
| creator | Shahnaz, Mohammad Kaur, Parminder Prasad, DN |
| description | NSAIDs suffer from a serious drawback of GI-SEs caused particularly after chronic use. There is evidence concerning the participation of ROS in the etiology & pathophysiology of digestive system disorders like GI-inflammation & gastro ulcer. With the aim to retard the adverse effects of GI-Origin, conjugates of NSAIDs (especially the carboxylic acid derivatives) with some antioxidants can be synthesized by esterification with various antioxidants of natural origin. The conjugates that show the retention or potentiating of anti-inflammatory activity with reduced ulcerogenic side effect could be potential gastroprotective co-drugs of NSAIDs.
Keyboards: NSAIDs, Gastroprotective, ROS, Natural antioxidants, Conjugates, Ulcerogenic |
| doi_str_mv | 10.22270/jddt.v8i5.1905 |
| format | Article |
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| identifier | ISSN: 2250-1177 |
| ispartof | Journal of drug delivery and therapeutics, 2018-09, Vol.8 (5), p.141-145 |
| issn | 2250-1177 2250-1177 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| title | GASTROPROTECTIVE NSAIDs |
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