Single-nucleotide polymorphism associations with efficacy and toxicity in metastatic castration-resistant prostate cancer treated with cabazitaxel

The aim of this study was to evaluate the impact of certain single-nucleotide polymorphisms (SNPs) in cabazitaxel activity and toxicity in patients with metastatic castration-resistant prostate cancer (mCRPC). 56 SNPs in five genes ( , , , and ) were genotyped in 67 mCRPC patients and their correlat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmacogenomics 2022-07, Vol.23 (11), p.627-638
Hauptverfasser:	Herrero Rivera, Daniel, Vacas, Carmen Garrigós, Kovandzic, Laura Marcos, Vázquez, Javier Puente, Alonso, Lucía A, González, Begoña Mellado, Aragón, Verónica Calderero, Grande, Enrique, Caro, Raquel Luque, Virizuela Echaburu, Juan A, Rodríguez Moreno, Juan F, Etxebarria, Ainara A, Rodríguez-Antona, Cristina, Durán, Ignacio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use ATP Binding Cassette Transporter, Subfamily B - genetics cabazitaxel Cytochrome P-450 CYP2C8 - genetics Cytochrome P-450 CYP3A - genetics Humans Male metastatic castration-resistant prostate cancer pharmacodynamics pharmacokinetics Polymorphism, Single Nucleotide Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - genetics Prostatic Neoplasms, Castration-Resistant - pathology single-nucleotide polymorphism taxanes Taxoids - adverse effects Taxoids - therapeutic use Treatment Outcome Tubulin - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!