Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance

This work aims to develop an injectable nano-drug delivery system to overcome tumor multidrug resistance (MDR). A drug delivery nanoplatform based on PEGylated PLGA with glutathione (GSH) responsivity was constructed for dual delivery of doxorubicin and curcumin (termed DCNP), and its MDR reversal e...

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Veröffentlicht in:	Nanomedicine (London, England) England), 2021-07, Vol.16 (16), p.1411-1427
Hauptverfasser:	Lai, Xuandi, Geng, Xinran, Li, Mengqing, Tang, Mengxiong, Liu, Qiong, Yang, Mengsu, Shen, Lin, Zhu, Yu, Wang, Shubin
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer therapy drug delivery GSH response multidrug resistance PLGA nanoparticles
Online-Zugang:	Volltext
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