1α,25-dihydroxyvitamin D 3 -eluting nanofibrous dressings induce endogenous antimicrobial peptide expression
The aim of this study was to develop a nanofiber-based dressing capable of local sustained delivery of 1α,25-dihydroxyvitamin D (1,25(OH) D ) and augmenting human CAMP induction. Nanofibrous wound dressings containing 1,25(OH) D were successfully prepared by electrospinning, which were examined in v...
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2018-06, Vol.13 (12), p.1417-1432 |
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| creator | Jiang, Jiang Zhang, Yang Indra, Arup K Ganguli-Indra, Gitali Le, Mai N Wang, Hongjun Hollins, Ronald R Reilly, Debra A Carlson, Mark A Gallo, Richard L Gombart, Adrian F Xie, Jingwei |
| description | The aim of this study was to develop a nanofiber-based dressing capable of local sustained delivery of 1α,25-dihydroxyvitamin D
(1,25(OH)
D
) and augmenting human CAMP induction.
Nanofibrous wound dressings containing 1,25(OH)
D
were successfully prepared by electrospinning, which were examined in vitro, in vivo and ex vivo.
1,25(OH)
D
was successfully loaded into nanofibers with encapsulation efficiency larger than 90%. 1,25(OH)
D
showed a sustained release from nanofibers over 4 weeks. Treatment of U937 and HaCaT cells with 1,25(OH)
D
-loaded poly(ϵ-caprolactone) nanofibers significantly induced hCAP18/LL37 expression in monocytes and keratinocytes, skin wounds of humanized transgenic mice and artificial wounds of human skin explants.
1,25(OH)
D
containing nanofibrous dressings could enhance innate immunity by inducing antimicrobial peptide production. |
| doi_str_mv | 10.2217/nnm-2018-0011 |
| format | Article |
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(1,25(OH)
D
) and augmenting human CAMP induction.
Nanofibrous wound dressings containing 1,25(OH)
D
were successfully prepared by electrospinning, which were examined in vitro, in vivo and ex vivo.
1,25(OH)
D
was successfully loaded into nanofibers with encapsulation efficiency larger than 90%. 1,25(OH)
D
showed a sustained release from nanofibers over 4 weeks. Treatment of U937 and HaCaT cells with 1,25(OH)
D
-loaded poly(ϵ-caprolactone) nanofibers significantly induced hCAP18/LL37 expression in monocytes and keratinocytes, skin wounds of humanized transgenic mice and artificial wounds of human skin explants.
1,25(OH)
D
containing nanofibrous dressings could enhance innate immunity by inducing antimicrobial peptide production.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm-2018-0011</identifier><identifier>PMID: 29972648</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Anti-Infective Agents - administration & dosage ; Anti-Infective Agents - chemistry ; Antimicrobial Cationic Peptides - chemistry ; Antimicrobial Cationic Peptides - metabolism ; Bandages - microbiology ; Cell Line ; Humans ; Keratinocytes - drug effects ; Keratinocytes - microbiology ; Mice ; Mice, Transgenic ; Monocytes - drug effects ; Nanofibers - administration & dosage ; Nanofibers - chemistry ; Vitamin D - administration & dosage ; Vitamin D - analogs & derivatives ; Vitamin D - chemistry ; Wound Closure Techniques</subject><ispartof>Nanomedicine (London, England), 2018-06, Vol.13 (12), p.1417-1432</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1058-4729b91ef63851e9ff514eee4f0b65e6bdc2d49b155ba4ab5ac47a4233a4f98f3</citedby><cites>FETCH-LOGICAL-c1058-4729b91ef63851e9ff514eee4f0b65e6bdc2d49b155ba4ab5ac47a4233a4f98f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29972648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiang, Jiang</creatorcontrib><creatorcontrib>Zhang, Yang</creatorcontrib><creatorcontrib>Indra, Arup K</creatorcontrib><creatorcontrib>Ganguli-Indra, Gitali</creatorcontrib><creatorcontrib>Le, Mai N</creatorcontrib><creatorcontrib>Wang, Hongjun</creatorcontrib><creatorcontrib>Hollins, Ronald R</creatorcontrib><creatorcontrib>Reilly, Debra A</creatorcontrib><creatorcontrib>Carlson, Mark A</creatorcontrib><creatorcontrib>Gallo, Richard L</creatorcontrib><creatorcontrib>Gombart, Adrian F</creatorcontrib><creatorcontrib>Xie, Jingwei</creatorcontrib><title>1α,25-dihydroxyvitamin D 3 -eluting nanofibrous dressings induce endogenous antimicrobial peptide expression</title><title>Nanomedicine (London, England)</title><addtitle>Nanomedicine (Lond)</addtitle><description>The aim of this study was to develop a nanofiber-based dressing capable of local sustained delivery of 1α,25-dihydroxyvitamin D
(1,25(OH)
D
) and augmenting human CAMP induction.
Nanofibrous wound dressings containing 1,25(OH)
D
were successfully prepared by electrospinning, which were examined in vitro, in vivo and ex vivo.
1,25(OH)
D
was successfully loaded into nanofibers with encapsulation efficiency larger than 90%. 1,25(OH)
D
showed a sustained release from nanofibers over 4 weeks. Treatment of U937 and HaCaT cells with 1,25(OH)
D
-loaded poly(ϵ-caprolactone) nanofibers significantly induced hCAP18/LL37 expression in monocytes and keratinocytes, skin wounds of humanized transgenic mice and artificial wounds of human skin explants.
1,25(OH)
D
containing nanofibrous dressings could enhance innate immunity by inducing antimicrobial peptide production.</description><subject>Animals</subject><subject>Anti-Infective Agents - administration & dosage</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Antimicrobial Cationic Peptides - chemistry</subject><subject>Antimicrobial Cationic Peptides - metabolism</subject><subject>Bandages - microbiology</subject><subject>Cell Line</subject><subject>Humans</subject><subject>Keratinocytes - drug effects</subject><subject>Keratinocytes - microbiology</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Monocytes - drug effects</subject><subject>Nanofibers - administration & dosage</subject><subject>Nanofibers - chemistry</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - chemistry</subject><subject>Wound Closure Techniques</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtOwzAQhi0EolBYskU-AAY_E3uJylOqxAbWkR3bxahxIjtB7bG4CGciaYHVjGa-Gf36ALgg-JpSUt7E2CCKiUQYE3IATkjJJSpUwQ53PUNCSjUDpzl_YCwkJfgYzKhSJS24PAEN-f66ogLZ8L61qd1sP0OvmxDhHWQQufXQh7iCUcfWB5PaIUObXM7jMMMQ7VA76KJtVy5OOx370IQ6tSboNexc1wc7Aptud9PGM3Dk9Tq78986B28P96-LJ7R8eXxe3C5RTcaMiJdUGUWcL5gUxCnvBeHOOe6xKYQrjK2p5coQIYzm2ghd81JzypjmXknP5gDt_45Rck7OV10KjU7biuBq0laN2qpJWzVpG_nLPd8NpnH2n_7zxH4AJ49sDA</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Jiang, Jiang</creator><creator>Zhang, Yang</creator><creator>Indra, Arup K</creator><creator>Ganguli-Indra, Gitali</creator><creator>Le, Mai N</creator><creator>Wang, Hongjun</creator><creator>Hollins, Ronald R</creator><creator>Reilly, Debra A</creator><creator>Carlson, Mark A</creator><creator>Gallo, Richard L</creator><creator>Gombart, Adrian F</creator><creator>Xie, Jingwei</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201806</creationdate><title>1α,25-dihydroxyvitamin D 3 -eluting nanofibrous dressings induce endogenous antimicrobial peptide expression</title><author>Jiang, Jiang ; Zhang, Yang ; Indra, Arup K ; Ganguli-Indra, Gitali ; Le, Mai N ; Wang, Hongjun ; Hollins, Ronald R ; Reilly, Debra A ; Carlson, Mark A ; Gallo, Richard L ; Gombart, Adrian F ; Xie, Jingwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1058-4729b91ef63851e9ff514eee4f0b65e6bdc2d49b155ba4ab5ac47a4233a4f98f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Anti-Infective Agents - administration & dosage</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Antimicrobial Cationic Peptides - chemistry</topic><topic>Antimicrobial Cationic Peptides - metabolism</topic><topic>Bandages - microbiology</topic><topic>Cell Line</topic><topic>Humans</topic><topic>Keratinocytes - drug effects</topic><topic>Keratinocytes - microbiology</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Monocytes - drug effects</topic><topic>Nanofibers - administration & dosage</topic><topic>Nanofibers - chemistry</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - chemistry</topic><topic>Wound Closure Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jiang, Jiang</creatorcontrib><creatorcontrib>Zhang, Yang</creatorcontrib><creatorcontrib>Indra, Arup K</creatorcontrib><creatorcontrib>Ganguli-Indra, Gitali</creatorcontrib><creatorcontrib>Le, Mai N</creatorcontrib><creatorcontrib>Wang, Hongjun</creatorcontrib><creatorcontrib>Hollins, Ronald R</creatorcontrib><creatorcontrib>Reilly, Debra A</creatorcontrib><creatorcontrib>Carlson, Mark A</creatorcontrib><creatorcontrib>Gallo, Richard L</creatorcontrib><creatorcontrib>Gombart, Adrian F</creatorcontrib><creatorcontrib>Xie, Jingwei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Nanomedicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jiang, Jiang</au><au>Zhang, Yang</au><au>Indra, Arup K</au><au>Ganguli-Indra, Gitali</au><au>Le, Mai N</au><au>Wang, Hongjun</au><au>Hollins, Ronald R</au><au>Reilly, Debra A</au><au>Carlson, Mark A</au><au>Gallo, Richard L</au><au>Gombart, Adrian F</au><au>Xie, Jingwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1α,25-dihydroxyvitamin D 3 -eluting nanofibrous dressings induce endogenous antimicrobial peptide expression</atitle><jtitle>Nanomedicine (London, England)</jtitle><addtitle>Nanomedicine (Lond)</addtitle><date>2018-06</date><risdate>2018</risdate><volume>13</volume><issue>12</issue><spage>1417</spage><epage>1432</epage><pages>1417-1432</pages><issn>1743-5889</issn><eissn>1748-6963</eissn><abstract>The aim of this study was to develop a nanofiber-based dressing capable of local sustained delivery of 1α,25-dihydroxyvitamin D
(1,25(OH)
D
) and augmenting human CAMP induction.
Nanofibrous wound dressings containing 1,25(OH)
D
were successfully prepared by electrospinning, which were examined in vitro, in vivo and ex vivo.
1,25(OH)
D
was successfully loaded into nanofibers with encapsulation efficiency larger than 90%. 1,25(OH)
D
showed a sustained release from nanofibers over 4 weeks. Treatment of U937 and HaCaT cells with 1,25(OH)
D
-loaded poly(ϵ-caprolactone) nanofibers significantly induced hCAP18/LL37 expression in monocytes and keratinocytes, skin wounds of humanized transgenic mice and artificial wounds of human skin explants.
1,25(OH)
D
containing nanofibrous dressings could enhance innate immunity by inducing antimicrobial peptide production.</abstract><cop>England</cop><pmid>29972648</pmid><doi>10.2217/nnm-2018-0011</doi><tpages>16</tpages></addata></record> |
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| identifier | ISSN: 1743-5889 |
| ispartof | Nanomedicine (London, England), 2018-06, Vol.13 (12), p.1417-1432 |
| issn | 1743-5889 1748-6963 |
| language | eng |
| recordid | cdi_crossref_primary_10_2217_nnm_2018_0011 |
| source | PubMed Central Free; MEDLINE |
| subjects | Animals Anti-Infective Agents - administration & dosage Anti-Infective Agents - chemistry Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - metabolism Bandages - microbiology Cell Line Humans Keratinocytes - drug effects Keratinocytes - microbiology Mice Mice, Transgenic Monocytes - drug effects Nanofibers - administration & dosage Nanofibers - chemistry Vitamin D - administration & dosage Vitamin D - analogs & derivatives Vitamin D - chemistry Wound Closure Techniques |
| title | 1α,25-dihydroxyvitamin D 3 -eluting nanofibrous dressings induce endogenous antimicrobial peptide expression |
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