Enhanced binding at fever temperatures of HER2 in complex with trastuzumab and pertuzumab

Fever follows the administration of trastuzumab and pertuzumab used in HER2-relevant immunotherapy, but is often eliminated in clinical practice. This work explores the role of temperature (37–39°C) in the formation of immune complexes between HER2 with either trastuzumab or pertuzumab or with both...

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Veröffentlicht in:	Immunotherapy 2023-09, Vol.15 (13), p.1021-1027
Hauptverfasser:	Singh, Puneet K, Stan, Razvan C
Format:	Artikel
Sprache:	eng
Schlagworte:	fever HER2 immunotherapy molecular dynamics pertuzumab trastuzumab
Online-Zugang:	Volltext
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