The influence of lifestyle factors on miRNA expression and signal pathways: a review
The term ‘lifestyle’ includes different factors that contribute to the maintenance of a good health status. Increasing evidences suggest that lifestyle factors may influence epigenetic mechanisms, such as miRNAs expression. The dysregulation of miRNAs can modify the expression of genes and molecular...
Gespeichert in:
| Veröffentlicht in: | Epigenomics 2021-01, Vol.13 (2), p.145-164 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 164 |
|---|---|
| container_issue | 2 |
| container_start_page | 145 |
| container_title | Epigenomics |
| container_volume | 13 |
| creator | Panico, Alessandra Tumolo, Maria R Leo, Carlo G Donno, Antonella De Grassi, Tiziana Bagordo, Francesco Serio, Francesca Idolo, Adele Masi, Roberto De Mincarone, Pierpaolo Sabina, Saverio |
| description | The term ‘lifestyle’ includes different factors that contribute to the maintenance of a good health status. Increasing evidences suggest that lifestyle factors may influence epigenetic mechanisms, such as miRNAs expression. The dysregulation of miRNAs can modify the expression of genes and molecular pathways that may lead to functional alterations. This review summarizes human studies highlighting that diet, physical activity, smoking and alcohol consumption may affect the miRNA machinery and several biological functions. Most miRNAs are involved in molecular pathways that influence inflammation, cell cycle regulation and carcinogenesis resulting in the onset or progression of pathological conditions. Investigating these interactions will be pivotal for understanding the etiology of pathologic processes, the potential new treatment strategies and for preventing diseases. |
| doi_str_mv | 10.2217/epi-2020-0289 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_2217_epi_2020_0289</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>33355508</sourcerecordid><originalsourceid>FETCH-LOGICAL-c343t-8ba9a629784d84dcf9db5d6a731b626bd2979619ccef8990a3b434bc3105e8353</originalsourceid><addsrcrecordid>eNp1kFtLwzAUgIMobsw9-ir5A9FceotvY3iDoSATfAtpeuIiXVua1tl_b0p1bx4C5yT5ziH5ELpk9Jpzlt5A4winnBLKM3mC5iyNKWGSv58ea8ZmaOn9Jw0hApWwczQTQsRxTLM52m53gF1lyx4qA7i2uHQWfDeUgK02Xd16XFd4716fVxi-mxa8d-FAVwX27qPSJW50tzvowd9ijVv4cnC4QGdWlx6Wv3mB3u7vtutHsnl5eFqvNsSISHQky7XUCZdpFhVhGSuLPC4SnQqWJzzJi3AV3iuNAZtJSbXIIxHlRjAaQyZisUBkmmva2vsWrGpat9ftoBhVoyAVBKlRkBoFBf5q4ps-30NxpP90BEBOgO27PnzVuNGKmnahwxlXwT_DfwAix3Ta</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The influence of lifestyle factors on miRNA expression and signal pathways: a review</title><source>MEDLINE</source><source>PubMed Central</source><creator>Panico, Alessandra ; Tumolo, Maria R ; Leo, Carlo G ; Donno, Antonella De ; Grassi, Tiziana ; Bagordo, Francesco ; Serio, Francesca ; Idolo, Adele ; Masi, Roberto De ; Mincarone, Pierpaolo ; Sabina, Saverio</creator><creatorcontrib>Panico, Alessandra ; Tumolo, Maria R ; Leo, Carlo G ; Donno, Antonella De ; Grassi, Tiziana ; Bagordo, Francesco ; Serio, Francesca ; Idolo, Adele ; Masi, Roberto De ; Mincarone, Pierpaolo ; Sabina, Saverio</creatorcontrib><description>The term ‘lifestyle’ includes different factors that contribute to the maintenance of a good health status. Increasing evidences suggest that lifestyle factors may influence epigenetic mechanisms, such as miRNAs expression. The dysregulation of miRNAs can modify the expression of genes and molecular pathways that may lead to functional alterations. This review summarizes human studies highlighting that diet, physical activity, smoking and alcohol consumption may affect the miRNA machinery and several biological functions. Most miRNAs are involved in molecular pathways that influence inflammation, cell cycle regulation and carcinogenesis resulting in the onset or progression of pathological conditions. Investigating these interactions will be pivotal for understanding the etiology of pathologic processes, the potential new treatment strategies and for preventing diseases.</description><identifier>ISSN: 1750-1911</identifier><identifier>EISSN: 1750-192X</identifier><identifier>DOI: 10.2217/epi-2020-0289</identifier><identifier>PMID: 33355508</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>alcohol consumption ; Alcohol Drinking - genetics ; Animals ; diet ; Epigenesis, Genetic - genetics ; Exercise - genetics ; health ; Humans ; Life Style ; lifestyle ; MicroRNAs - genetics ; miRNA ; physical activity ; signal pathways ; Signal Transduction - genetics ; smoking ; Smoking - genetics</subject><ispartof>Epigenomics, 2021-01, Vol.13 (2), p.145-164</ispartof><rights>2020 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-8ba9a629784d84dcf9db5d6a731b626bd2979619ccef8990a3b434bc3105e8353</citedby><cites>FETCH-LOGICAL-c343t-8ba9a629784d84dcf9db5d6a731b626bd2979619ccef8990a3b434bc3105e8353</cites><orcidid>0000-0002-1876-7184 ; 0000-0003-1200-2778 ; 0000-0002-7587-8112 ; 0000-0001-8349-2466 ; 0000-0001-5208-5382 ; 0000-0002-2782-2798 ; 0000-0002-5337-2356 ; 0000-0002-6049-1986 ; 0000-0002-1357-4578 ; 0000-0002-8396-4731</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33355508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Panico, Alessandra</creatorcontrib><creatorcontrib>Tumolo, Maria R</creatorcontrib><creatorcontrib>Leo, Carlo G</creatorcontrib><creatorcontrib>Donno, Antonella De</creatorcontrib><creatorcontrib>Grassi, Tiziana</creatorcontrib><creatorcontrib>Bagordo, Francesco</creatorcontrib><creatorcontrib>Serio, Francesca</creatorcontrib><creatorcontrib>Idolo, Adele</creatorcontrib><creatorcontrib>Masi, Roberto De</creatorcontrib><creatorcontrib>Mincarone, Pierpaolo</creatorcontrib><creatorcontrib>Sabina, Saverio</creatorcontrib><title>The influence of lifestyle factors on miRNA expression and signal pathways: a review</title><title>Epigenomics</title><addtitle>Epigenomics</addtitle><description>The term ‘lifestyle’ includes different factors that contribute to the maintenance of a good health status. Increasing evidences suggest that lifestyle factors may influence epigenetic mechanisms, such as miRNAs expression. The dysregulation of miRNAs can modify the expression of genes and molecular pathways that may lead to functional alterations. This review summarizes human studies highlighting that diet, physical activity, smoking and alcohol consumption may affect the miRNA machinery and several biological functions. Most miRNAs are involved in molecular pathways that influence inflammation, cell cycle regulation and carcinogenesis resulting in the onset or progression of pathological conditions. Investigating these interactions will be pivotal for understanding the etiology of pathologic processes, the potential new treatment strategies and for preventing diseases.</description><subject>alcohol consumption</subject><subject>Alcohol Drinking - genetics</subject><subject>Animals</subject><subject>diet</subject><subject>Epigenesis, Genetic - genetics</subject><subject>Exercise - genetics</subject><subject>health</subject><subject>Humans</subject><subject>Life Style</subject><subject>lifestyle</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>physical activity</subject><subject>signal pathways</subject><subject>Signal Transduction - genetics</subject><subject>smoking</subject><subject>Smoking - genetics</subject><issn>1750-1911</issn><issn>1750-192X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kFtLwzAUgIMobsw9-ir5A9FceotvY3iDoSATfAtpeuIiXVua1tl_b0p1bx4C5yT5ziH5ELpk9Jpzlt5A4winnBLKM3mC5iyNKWGSv58ea8ZmaOn9Jw0hApWwczQTQsRxTLM52m53gF1lyx4qA7i2uHQWfDeUgK02Xd16XFd4716fVxi-mxa8d-FAVwX27qPSJW50tzvowd9ijVv4cnC4QGdWlx6Wv3mB3u7vtutHsnl5eFqvNsSISHQky7XUCZdpFhVhGSuLPC4SnQqWJzzJi3AV3iuNAZtJSbXIIxHlRjAaQyZisUBkmmva2vsWrGpat9ftoBhVoyAVBKlRkBoFBf5q4ps-30NxpP90BEBOgO27PnzVuNGKmnahwxlXwT_DfwAix3Ta</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Panico, Alessandra</creator><creator>Tumolo, Maria R</creator><creator>Leo, Carlo G</creator><creator>Donno, Antonella De</creator><creator>Grassi, Tiziana</creator><creator>Bagordo, Francesco</creator><creator>Serio, Francesca</creator><creator>Idolo, Adele</creator><creator>Masi, Roberto De</creator><creator>Mincarone, Pierpaolo</creator><creator>Sabina, Saverio</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-1876-7184</orcidid><orcidid>https://orcid.org/0000-0003-1200-2778</orcidid><orcidid>https://orcid.org/0000-0002-7587-8112</orcidid><orcidid>https://orcid.org/0000-0001-8349-2466</orcidid><orcidid>https://orcid.org/0000-0001-5208-5382</orcidid><orcidid>https://orcid.org/0000-0002-2782-2798</orcidid><orcidid>https://orcid.org/0000-0002-5337-2356</orcidid><orcidid>https://orcid.org/0000-0002-6049-1986</orcidid><orcidid>https://orcid.org/0000-0002-1357-4578</orcidid><orcidid>https://orcid.org/0000-0002-8396-4731</orcidid></search><sort><creationdate>20210101</creationdate><title>The influence of lifestyle factors on miRNA expression and signal pathways: a review</title><author>Panico, Alessandra ; Tumolo, Maria R ; Leo, Carlo G ; Donno, Antonella De ; Grassi, Tiziana ; Bagordo, Francesco ; Serio, Francesca ; Idolo, Adele ; Masi, Roberto De ; Mincarone, Pierpaolo ; Sabina, Saverio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-8ba9a629784d84dcf9db5d6a731b626bd2979619ccef8990a3b434bc3105e8353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>alcohol consumption</topic><topic>Alcohol Drinking - genetics</topic><topic>Animals</topic><topic>diet</topic><topic>Epigenesis, Genetic - genetics</topic><topic>Exercise - genetics</topic><topic>health</topic><topic>Humans</topic><topic>Life Style</topic><topic>lifestyle</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>physical activity</topic><topic>signal pathways</topic><topic>Signal Transduction - genetics</topic><topic>smoking</topic><topic>Smoking - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panico, Alessandra</creatorcontrib><creatorcontrib>Tumolo, Maria R</creatorcontrib><creatorcontrib>Leo, Carlo G</creatorcontrib><creatorcontrib>Donno, Antonella De</creatorcontrib><creatorcontrib>Grassi, Tiziana</creatorcontrib><creatorcontrib>Bagordo, Francesco</creatorcontrib><creatorcontrib>Serio, Francesca</creatorcontrib><creatorcontrib>Idolo, Adele</creatorcontrib><creatorcontrib>Masi, Roberto De</creatorcontrib><creatorcontrib>Mincarone, Pierpaolo</creatorcontrib><creatorcontrib>Sabina, Saverio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Epigenomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Panico, Alessandra</au><au>Tumolo, Maria R</au><au>Leo, Carlo G</au><au>Donno, Antonella De</au><au>Grassi, Tiziana</au><au>Bagordo, Francesco</au><au>Serio, Francesca</au><au>Idolo, Adele</au><au>Masi, Roberto De</au><au>Mincarone, Pierpaolo</au><au>Sabina, Saverio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of lifestyle factors on miRNA expression and signal pathways: a review</atitle><jtitle>Epigenomics</jtitle><addtitle>Epigenomics</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>13</volume><issue>2</issue><spage>145</spage><epage>164</epage><pages>145-164</pages><issn>1750-1911</issn><eissn>1750-192X</eissn><abstract>The term ‘lifestyle’ includes different factors that contribute to the maintenance of a good health status. Increasing evidences suggest that lifestyle factors may influence epigenetic mechanisms, such as miRNAs expression. The dysregulation of miRNAs can modify the expression of genes and molecular pathways that may lead to functional alterations. This review summarizes human studies highlighting that diet, physical activity, smoking and alcohol consumption may affect the miRNA machinery and several biological functions. Most miRNAs are involved in molecular pathways that influence inflammation, cell cycle regulation and carcinogenesis resulting in the onset or progression of pathological conditions. Investigating these interactions will be pivotal for understanding the etiology of pathologic processes, the potential new treatment strategies and for preventing diseases.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>33355508</pmid><doi>10.2217/epi-2020-0289</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0002-1876-7184</orcidid><orcidid>https://orcid.org/0000-0003-1200-2778</orcidid><orcidid>https://orcid.org/0000-0002-7587-8112</orcidid><orcidid>https://orcid.org/0000-0001-8349-2466</orcidid><orcidid>https://orcid.org/0000-0001-5208-5382</orcidid><orcidid>https://orcid.org/0000-0002-2782-2798</orcidid><orcidid>https://orcid.org/0000-0002-5337-2356</orcidid><orcidid>https://orcid.org/0000-0002-6049-1986</orcidid><orcidid>https://orcid.org/0000-0002-1357-4578</orcidid><orcidid>https://orcid.org/0000-0002-8396-4731</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1750-1911 |
| ispartof | Epigenomics, 2021-01, Vol.13 (2), p.145-164 |
| issn | 1750-1911 1750-192X |
| language | eng |
| recordid | cdi_crossref_primary_10_2217_epi_2020_0289 |
| source | MEDLINE; PubMed Central |
| subjects | alcohol consumption Alcohol Drinking - genetics Animals diet Epigenesis, Genetic - genetics Exercise - genetics health Humans Life Style lifestyle MicroRNAs - genetics miRNA physical activity signal pathways Signal Transduction - genetics smoking Smoking - genetics |
| title | The influence of lifestyle factors on miRNA expression and signal pathways: a review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T10%3A42%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20influence%20of%20lifestyle%20factors%20on%20miRNA%20expression%20and%20signal%20pathways:%20a%20review&rft.jtitle=Epigenomics&rft.au=Panico,%20Alessandra&rft.date=2021-01-01&rft.volume=13&rft.issue=2&rft.spage=145&rft.epage=164&rft.pages=145-164&rft.issn=1750-1911&rft.eissn=1750-192X&rft_id=info:doi/10.2217/epi-2020-0289&rft_dat=%3Cpubmed_cross%3E33355508%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/33355508&rfr_iscdi=true |