H19 promotes the gastric carcinogenesis by sponging miR-29a-3p : evidence from lncRNA-miRNA-mRNA network analysis

To identify novel competing endogenous RNA (ceRNA) network correlated with the prognosis of gastric cancer (GC) patients. We systematically analyzed the aberrantly expressed genes in human GC to construct a ceRNA network by using multiple bioinformatic tools. Aberrantly expressed mRNAs in GC were identified. By means of stepwise reverse prediction and validation from mRNA to lncRNA, a ceRNA network comprised of and was constructed, and all genes in the network are significantly correlated with the prognosis of GC patients. The present study successfully constructed a GC related ceRNA network, and provided potential targets for GC clinical treatment.