The Agony of Ecstasy: MDMA (3,4-Methylenedioxymethamphetamine) and the Kidney
Ecstasy (MDMA, 3,4-methylenedioxymethamphetamine) is commonly used by college-aged individuals. Ecstasy leads to feelings of euphoria, emotional empathy, and increased energy. These effects come at a significant risk for complications. Ecstasy has been associated with acute kidney injury that is mos...
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| Veröffentlicht in: | Clinical journal of the American Society of Nephrology 2008-11, Vol.3 (6), p.1852-1860 |
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| container_title | Clinical journal of the American Society of Nephrology |
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| creator | Campbell, Garland A Rosner, Mitchell H |
| description | Ecstasy (MDMA, 3,4-methylenedioxymethamphetamine) is commonly used by college-aged individuals. Ecstasy leads to feelings of euphoria, emotional empathy, and increased energy. These effects come at a significant risk for complications. Ecstasy has been associated with acute kidney injury that is most commonly secondary to nontraumatic rhabdomyolysis but also has been reported in the setting of drug-induced liver failure and drug-induced vasculitis. More common, ecstasy has led to serious hyponatremia and hyponatremia-associated deaths. Hyponatremia in these cases is due to a "perfect storm" of ecstasy-induced effects on water balance. Ecstasy leads to secretion of arginine vasopressin as well as polydipsia as a result of its effects on the serotonergic nervous pathways. Compounding these effects are the ready availability of fluids and the recommendation to drink copiously at rave parties where ecstasy is used. The effects of ecstasy on the kidney as well as therapeutic measures for the treatment of ecstasy-induced hyponatremia are presented. |
| doi_str_mv | 10.2215/CJN.02080508 |
| format | Article |
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Ecstasy leads to feelings of euphoria, emotional empathy, and increased energy. These effects come at a significant risk for complications. Ecstasy has been associated with acute kidney injury that is most commonly secondary to nontraumatic rhabdomyolysis but also has been reported in the setting of drug-induced liver failure and drug-induced vasculitis. More common, ecstasy has led to serious hyponatremia and hyponatremia-associated deaths. Hyponatremia in these cases is due to a "perfect storm" of ecstasy-induced effects on water balance. Ecstasy leads to secretion of arginine vasopressin as well as polydipsia as a result of its effects on the serotonergic nervous pathways. Compounding these effects are the ready availability of fluids and the recommendation to drink copiously at rave parties where ecstasy is used. The effects of ecstasy on the kidney as well as therapeutic measures for the treatment of ecstasy-induced hyponatremia are presented.</description><identifier>ISSN: 1555-9041</identifier><identifier>EISSN: 1555-905X</identifier><identifier>DOI: 10.2215/CJN.02080508</identifier><identifier>PMID: 18684895</identifier><language>eng</language><publisher>United States: American Society of Nephrology</publisher><subject>Acute Disease ; Adolescent ; Adult ; Female ; Hallucinogens - adverse effects ; Humans ; Hyponatremia - chemically induced ; Hyponatremia - metabolism ; Hyponatremia - therapy ; Kidney - drug effects ; Kidney - metabolism ; Kidney - physiopathology ; Kidney Diseases - chemically induced ; Kidney Diseases - metabolism ; Kidney Diseases - therapy ; Male ; N-Methyl-3,4-methylenedioxyamphetamine - adverse effects ; Syndrome ; Water-Electrolyte Balance - drug effects ; Young Adult</subject><ispartof>Clinical journal of the American Society of Nephrology, 2008-11, Vol.3 (6), p.1852-1860</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18684895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campbell, Garland A</creatorcontrib><creatorcontrib>Rosner, Mitchell H</creatorcontrib><title>The Agony of Ecstasy: MDMA (3,4-Methylenedioxymethamphetamine) and the Kidney</title><title>Clinical journal of the American Society of Nephrology</title><addtitle>Clin J Am Soc Nephrol</addtitle><description>Ecstasy (MDMA, 3,4-methylenedioxymethamphetamine) is commonly used by college-aged individuals. Ecstasy leads to feelings of euphoria, emotional empathy, and increased energy. These effects come at a significant risk for complications. Ecstasy has been associated with acute kidney injury that is most commonly secondary to nontraumatic rhabdomyolysis but also has been reported in the setting of drug-induced liver failure and drug-induced vasculitis. More common, ecstasy has led to serious hyponatremia and hyponatremia-associated deaths. Hyponatremia in these cases is due to a "perfect storm" of ecstasy-induced effects on water balance. Ecstasy leads to secretion of arginine vasopressin as well as polydipsia as a result of its effects on the serotonergic nervous pathways. Compounding these effects are the ready availability of fluids and the recommendation to drink copiously at rave parties where ecstasy is used. The effects of ecstasy on the kidney as well as therapeutic measures for the treatment of ecstasy-induced hyponatremia are presented.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Female</subject><subject>Hallucinogens - adverse effects</subject><subject>Humans</subject><subject>Hyponatremia - chemically induced</subject><subject>Hyponatremia - metabolism</subject><subject>Hyponatremia - therapy</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney - physiopathology</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - metabolism</subject><subject>Kidney Diseases - therapy</subject><subject>Male</subject><subject>N-Methyl-3,4-methylenedioxyamphetamine - adverse effects</subject><subject>Syndrome</subject><subject>Water-Electrolyte Balance - drug effects</subject><subject>Young Adult</subject><issn>1555-9041</issn><issn>1555-905X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0DtPwzAQwHELgSgUNmbkDZCa4ncctqqUZwNLkdgs13aaVHlUcRDk22PUAtPdST_d8AfgDKMxIZhfT59exoggiTiSe-AIc86jBPH3_b-d4QE49n6NEGOU8EMwwFJIJhN-BNJF7uBk1dQ9bDI4M77Tvr-B6W06gZd0xKLUdXlfutrZovnqq3DpapO7TldF7a6gri3swovnwtauPwEHmS69O93NIXi7my2mD9H89f5xOplHhsSyi5izMRIUm4xhLdgyoVZwY4XFRsSxzjJiBaZcW8IMipeEJJZp5gTlRMTCSToEo-1f0zbety5Tm7aodNsrjNRPFRWqqN8qgZ9v-eZjWTn7j3cZArjYgrxY5Z9F65SvdFkGTpRZa19TJYLmhH4DqYJpAw</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Campbell, Garland A</creator><creator>Rosner, Mitchell H</creator><general>American Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20081101</creationdate><title>The Agony of Ecstasy: MDMA (3,4-Methylenedioxymethamphetamine) and the Kidney</title><author>Campbell, Garland A ; Rosner, Mitchell H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c278t-4ed70631cf41a64b93d65cd6d1c677aff2d6135ad24c07b229d4a4e6352676e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Female</topic><topic>Hallucinogens - adverse effects</topic><topic>Humans</topic><topic>Hyponatremia - chemically induced</topic><topic>Hyponatremia - metabolism</topic><topic>Hyponatremia - therapy</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney - physiopathology</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - metabolism</topic><topic>Kidney Diseases - therapy</topic><topic>Male</topic><topic>N-Methyl-3,4-methylenedioxyamphetamine - adverse effects</topic><topic>Syndrome</topic><topic>Water-Electrolyte Balance - drug effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campbell, Garland A</creatorcontrib><creatorcontrib>Rosner, Mitchell H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Clinical journal of the American Society of Nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campbell, Garland A</au><au>Rosner, Mitchell H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Agony of Ecstasy: MDMA (3,4-Methylenedioxymethamphetamine) and the Kidney</atitle><jtitle>Clinical journal of the American Society of Nephrology</jtitle><addtitle>Clin J Am Soc Nephrol</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>3</volume><issue>6</issue><spage>1852</spage><epage>1860</epage><pages>1852-1860</pages><issn>1555-9041</issn><eissn>1555-905X</eissn><abstract>Ecstasy (MDMA, 3,4-methylenedioxymethamphetamine) is commonly used by college-aged individuals. Ecstasy leads to feelings of euphoria, emotional empathy, and increased energy. These effects come at a significant risk for complications. Ecstasy has been associated with acute kidney injury that is most commonly secondary to nontraumatic rhabdomyolysis but also has been reported in the setting of drug-induced liver failure and drug-induced vasculitis. More common, ecstasy has led to serious hyponatremia and hyponatremia-associated deaths. Hyponatremia in these cases is due to a "perfect storm" of ecstasy-induced effects on water balance. Ecstasy leads to secretion of arginine vasopressin as well as polydipsia as a result of its effects on the serotonergic nervous pathways. Compounding these effects are the ready availability of fluids and the recommendation to drink copiously at rave parties where ecstasy is used. The effects of ecstasy on the kidney as well as therapeutic measures for the treatment of ecstasy-induced hyponatremia are presented.</abstract><cop>United States</cop><pub>American Society of Nephrology</pub><pmid>18684895</pmid><doi>10.2215/CJN.02080508</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 1555-9041 |
| ispartof | Clinical journal of the American Society of Nephrology, 2008-11, Vol.3 (6), p.1852-1860 |
| issn | 1555-9041 1555-905X |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acute Disease Adolescent Adult Female Hallucinogens - adverse effects Humans Hyponatremia - chemically induced Hyponatremia - metabolism Hyponatremia - therapy Kidney - drug effects Kidney - metabolism Kidney - physiopathology Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Diseases - therapy Male N-Methyl-3,4-methylenedioxyamphetamine - adverse effects Syndrome Water-Electrolyte Balance - drug effects Young Adult |
| title | The Agony of Ecstasy: MDMA (3,4-Methylenedioxymethamphetamine) and the Kidney |
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