ANTIMICROBIAL PROFILES, ANTIDIARRHEAL AND ANTIPYRETIC CAPACITIES OF PHENOL ACID RICH-FRACTIONS FROM XIMENIA AMERICA L., (OLACACEAE) IN WISTAR ALBINO RATS

Objective: The present study aim to evaluate antimicrobial and antidiarrheal activities of phenol acid-rich fractions of roots from Ximenia americana L., in animal models in order to confirm the ethnomedicinal use of Ximenia Americana L., roots.Methods: In vitro antibacterial (Minimum inhibitory concentration (MIC), Minimum bactericidal concentration (MBC) and time-kill studies) of phenol-rich fractions of roots from Ximenia americana L., was assessed using eight bacteria strains (Gram-negative). The anti-diarrheal activity was evaluated using castor using castor oil induced diarrhea whereas Anti-secretory activity was investigated using castor oil-induced enteropooling assay examined in animal models respectively.Results: All test bacteria were susceptible to the phenol-rich fractions. Time-kill results showed that after 5 h exposition there was no viable microorganism in the initial inoculum. Moreover, phenol acid-rich fractions of roots (100-200 and 300 mg/kg, p. o.) produced dose-dependent and significant (p