THERAPEUTIC IMPORTANCE OF CURCUMIN WITH A SPECIAL EMPHASIS ON MDR CANCER CELLS AND THE FACTORS INFLUENCING PHARMACODYNAMICS

Curcuma longa or turmeric is a plant that is used as a spice and as a phytoconstituent in many formulations from Vedic age. Curcuminoids are the most important Phyto constituents present in turmeric with various pharmacological activities. The present study reveals various pharmacological activities of curcumin with special emphasis on MDR cancer cells. The curcuminoids are the Phyto constituents showing potent activity against neurological disorders, cardio vascular diseases, auto immune disorders, Metabolic disorders, cancer, inflammatory diseases, Skin allergies and disorders. This review give emphasis on anticancer activity of curcumin and its possible mechanism of actions. Many studies revealing that various formulations and combination therapy of curcumin is increasing its bioavailability and there by effective against various diseases. This review is lighting to a treasure buried inside the soil a potential therapeutic agent without side effects.