Anti-Urolithiatic Activity of Heart Wood Extract of Cedrus deodara in Rats
Abstract The petroleum ether extract of the heart wood of Cedrus deodara (PECD) was tested for its diuretic and anti-urolithiatic activity. The urolithiasis was experimentally induced by administering sodium oxalate (70 mg/kg, i.p) for 10 days. PECD (100 and 200 mg/kg) was orally gavaged daily 1 h b...
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| Veröffentlicht in: | Journal of Complementary and Integrative Medicine 2010-04, Vol.7 (1), p.11 |
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| creator | C., Ramesh Krishnadas, Nandakumar Radhakrishnan, Rajesh Rangappa, Srinath Viswanatha, Gollapalle Lakshminarayana Shastry D, Rajesh Gopal, Murugananthan Talwar, Sahil |
| description | Abstract
The petroleum ether extract of the heart wood of Cedrus deodara (PECD) was tested for its diuretic and anti-urolithiatic activity. The urolithiasis was experimentally induced by administering sodium oxalate (70 mg/kg, i.p) for 10 days. PECD (100 and 200 mg/kg) was orally gavaged daily 1 h before sodium oxalate (NaOx) administration for 10 days. In NaOx treated rats, crystal was observed in urine under light microscope and elevation of serum parameters indicated the development of nephrolithiasis in the control group. Concomitant administration of PECD for 10 days along with NaOx prevented elevated serum biochemical levels due to the elimination of these in urine. Histology of the kidneys also indicated that PECD treatment had protected against NaOx induced nephroliathiasis. These results obtained, confirmed the beneficiary effect of Cedrus deodara in urolithiasis.
Submitted: August 19, 2009 · Accepted: February 23, 2010 · Published: April 7, 2010
Recommended Citation
C., Ramesh; Krishnadas, Nandakumar; Radhakrishnan, Rajesh; Rangappa, Srinath; Viswanatha, Gollapalle Lakshminarayana Shastry; D, Rajesh; Gopal, Murugananthan; and Talwar, Sahil
(2010)
"Anti-Urolithiatic Activity of Heart Wood Extract of Cedrus deodara in Rats,"
Journal of Complementary and Integrative Medicine:
Vol. 7
:
Iss.
1, Article 11.
DOI: 10.2202/1553-3840.1311
Available at: http://www.bepress.com/jcim/vol7/iss1/11 |
| doi_str_mv | 10.2202/1553-3840.1311 |
| format | Article |
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The petroleum ether extract of the heart wood of Cedrus deodara (PECD) was tested for its diuretic and anti-urolithiatic activity. The urolithiasis was experimentally induced by administering sodium oxalate (70 mg/kg, i.p) for 10 days. PECD (100 and 200 mg/kg) was orally gavaged daily 1 h before sodium oxalate (NaOx) administration for 10 days. In NaOx treated rats, crystal was observed in urine under light microscope and elevation of serum parameters indicated the development of nephrolithiasis in the control group. Concomitant administration of PECD for 10 days along with NaOx prevented elevated serum biochemical levels due to the elimination of these in urine. Histology of the kidneys also indicated that PECD treatment had protected against NaOx induced nephroliathiasis. These results obtained, confirmed the beneficiary effect of Cedrus deodara in urolithiasis.
Submitted: August 19, 2009 · Accepted: February 23, 2010 · Published: April 7, 2010
Recommended Citation
C., Ramesh; Krishnadas, Nandakumar; Radhakrishnan, Rajesh; Rangappa, Srinath; Viswanatha, Gollapalle Lakshminarayana Shastry; D, Rajesh; Gopal, Murugananthan; and Talwar, Sahil
(2010)
"Anti-Urolithiatic Activity of Heart Wood Extract of Cedrus deodara in Rats,"
Journal of Complementary and Integrative Medicine:
Vol. 7
:
Iss.
1, Article 11.
DOI: 10.2202/1553-3840.1311
Available at: http://www.bepress.com/jcim/vol7/iss1/11</description><identifier>ISSN: 1553-3840</identifier><identifier>EISSN: 1553-3840</identifier><identifier>DOI: 10.2202/1553-3840.1311</identifier><language>eng</language><publisher>bepress</publisher><subject>anti-urolithiatic ; Cedrus deodara ; diuretic</subject><ispartof>Journal of Complementary and Integrative Medicine, 2010-04, Vol.7 (1), p.11</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>C., Ramesh</creatorcontrib><creatorcontrib>Krishnadas, Nandakumar</creatorcontrib><creatorcontrib>Radhakrishnan, Rajesh</creatorcontrib><creatorcontrib>Rangappa, Srinath</creatorcontrib><creatorcontrib>Viswanatha, Gollapalle Lakshminarayana Shastry</creatorcontrib><creatorcontrib>D, Rajesh</creatorcontrib><creatorcontrib>Gopal, Murugananthan</creatorcontrib><creatorcontrib>Talwar, Sahil</creatorcontrib><title>Anti-Urolithiatic Activity of Heart Wood Extract of Cedrus deodara in Rats</title><title>Journal of Complementary and Integrative Medicine</title><addtitle>J Complement Integr Med</addtitle><description>Abstract
The petroleum ether extract of the heart wood of Cedrus deodara (PECD) was tested for its diuretic and anti-urolithiatic activity. The urolithiasis was experimentally induced by administering sodium oxalate (70 mg/kg, i.p) for 10 days. PECD (100 and 200 mg/kg) was orally gavaged daily 1 h before sodium oxalate (NaOx) administration for 10 days. In NaOx treated rats, crystal was observed in urine under light microscope and elevation of serum parameters indicated the development of nephrolithiasis in the control group. Concomitant administration of PECD for 10 days along with NaOx prevented elevated serum biochemical levels due to the elimination of these in urine. Histology of the kidneys also indicated that PECD treatment had protected against NaOx induced nephroliathiasis. These results obtained, confirmed the beneficiary effect of Cedrus deodara in urolithiasis.
Submitted: August 19, 2009 · Accepted: February 23, 2010 · Published: April 7, 2010
Recommended Citation
C., Ramesh; Krishnadas, Nandakumar; Radhakrishnan, Rajesh; Rangappa, Srinath; Viswanatha, Gollapalle Lakshminarayana Shastry; D, Rajesh; Gopal, Murugananthan; and Talwar, Sahil
(2010)
"Anti-Urolithiatic Activity of Heart Wood Extract of Cedrus deodara in Rats,"
Journal of Complementary and Integrative Medicine:
Vol. 7
:
Iss.
1, Article 11.
DOI: 10.2202/1553-3840.1311
Available at: http://www.bepress.com/jcim/vol7/iss1/11</description><subject>anti-urolithiatic</subject><subject>Cedrus deodara</subject><subject>diuretic</subject><issn>1553-3840</issn><issn>1553-3840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNpNkEtPAjEUhRujiYhu3do_MNjb18wsgaioJEYDcdl0-ohFYEhbDfx7GTHE1b05-c5JzkHoGsiAUkJvQQhWsIqTATCAE9Q7Cqf__nN0kdKCEFYzWvbQ03CdQzGP7TLkj6BzMHhocvgOeYdbjydOx4zf29biu22O2uROHTsbvxK2rrU6ahzW-E3ndInOvF4md_V3-2h-fzcbT4rpy8PjeDgtGighF1IKkJXnppZGatNYC-BMJbjnVlRceiF4Ra32Nakl4TU1lBpoQOpSEwea9dHgkGtim1J0Xm1iWOm4U0BUt4TqyqqurOqW2BuKgyGk7LZHWsdPJUtWCvU64-p5KshoJECRPX9z4Bu3iS6lo2Nhwuo38QdD1ml7</recordid><startdate>20100407</startdate><enddate>20100407</enddate><creator>C., Ramesh</creator><creator>Krishnadas, Nandakumar</creator><creator>Radhakrishnan, Rajesh</creator><creator>Rangappa, Srinath</creator><creator>Viswanatha, Gollapalle Lakshminarayana Shastry</creator><creator>D, Rajesh</creator><creator>Gopal, Murugananthan</creator><creator>Talwar, Sahil</creator><general>bepress</general><general>De Gruyter</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20100407</creationdate><title>Anti-Urolithiatic Activity of Heart Wood Extract of Cedrus deodara in Rats</title><author>C., Ramesh ; Krishnadas, Nandakumar ; Radhakrishnan, Rajesh ; Rangappa, Srinath ; Viswanatha, Gollapalle Lakshminarayana Shastry ; D, Rajesh ; Gopal, Murugananthan ; Talwar, Sahil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b171t-665168f4c96c6acbdd11ec854f4d5846f55482daf90960492c22c1b16a7a0e1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>anti-urolithiatic</topic><topic>Cedrus deodara</topic><topic>diuretic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>C., Ramesh</creatorcontrib><creatorcontrib>Krishnadas, Nandakumar</creatorcontrib><creatorcontrib>Radhakrishnan, Rajesh</creatorcontrib><creatorcontrib>Rangappa, Srinath</creatorcontrib><creatorcontrib>Viswanatha, Gollapalle Lakshminarayana Shastry</creatorcontrib><creatorcontrib>D, Rajesh</creatorcontrib><creatorcontrib>Gopal, Murugananthan</creatorcontrib><creatorcontrib>Talwar, Sahil</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>Journal of Complementary and Integrative Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>C., Ramesh</au><au>Krishnadas, Nandakumar</au><au>Radhakrishnan, Rajesh</au><au>Rangappa, Srinath</au><au>Viswanatha, Gollapalle Lakshminarayana Shastry</au><au>D, Rajesh</au><au>Gopal, Murugananthan</au><au>Talwar, Sahil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Urolithiatic Activity of Heart Wood Extract of Cedrus deodara in Rats</atitle><jtitle>Journal of Complementary and Integrative Medicine</jtitle><addtitle>J Complement Integr Med</addtitle><date>2010-04-07</date><risdate>2010</risdate><volume>7</volume><issue>1</issue><spage>11</spage><pages>11-</pages><issn>1553-3840</issn><eissn>1553-3840</eissn><abstract>Abstract
The petroleum ether extract of the heart wood of Cedrus deodara (PECD) was tested for its diuretic and anti-urolithiatic activity. The urolithiasis was experimentally induced by administering sodium oxalate (70 mg/kg, i.p) for 10 days. PECD (100 and 200 mg/kg) was orally gavaged daily 1 h before sodium oxalate (NaOx) administration for 10 days. In NaOx treated rats, crystal was observed in urine under light microscope and elevation of serum parameters indicated the development of nephrolithiasis in the control group. Concomitant administration of PECD for 10 days along with NaOx prevented elevated serum biochemical levels due to the elimination of these in urine. Histology of the kidneys also indicated that PECD treatment had protected against NaOx induced nephroliathiasis. These results obtained, confirmed the beneficiary effect of Cedrus deodara in urolithiasis.
Submitted: August 19, 2009 · Accepted: February 23, 2010 · Published: April 7, 2010
Recommended Citation
C., Ramesh; Krishnadas, Nandakumar; Radhakrishnan, Rajesh; Rangappa, Srinath; Viswanatha, Gollapalle Lakshminarayana Shastry; D, Rajesh; Gopal, Murugananthan; and Talwar, Sahil
(2010)
"Anti-Urolithiatic Activity of Heart Wood Extract of Cedrus deodara in Rats,"
Journal of Complementary and Integrative Medicine:
Vol. 7
:
Iss.
1, Article 11.
DOI: 10.2202/1553-3840.1311
Available at: http://www.bepress.com/jcim/vol7/iss1/11</abstract><pub>bepress</pub><doi>10.2202/1553-3840.1311</doi></addata></record> |
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| source | De Gruyter journals |
| subjects | anti-urolithiatic Cedrus deodara diuretic |
| title | Anti-Urolithiatic Activity of Heart Wood Extract of Cedrus deodara in Rats |
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