Changes in Urinary Thromboxane Level in Man During Cardiopulmonary Bypass

Changes in Urinary Thromboxane Level in Man During Cardiopulmonary Bypass

We measured urinary and plasma level of prostaglandins during cardiopulmonary bypass (CPB) and their clinical significance. The urinary levels of NAG was also measured at the same time. Urinary and plasma levels of TXB2 and 6keto PGF1α were increased upon initiation of CPB. The urinary NAG level inc...

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Veröffentlicht in:Nihon Rinshō Masui Gakkai shi 1989/03/15, Vol.9(2), pp.156-160
Hauptverfasser: ARIMA, Tadashi, OHATA, Miyoko, MATSUURA, Moto, KUROKI, Kyoko, MATSUMOTO, Isao, HORI, Takao
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container_issue 2
container_start_page 156
container_title Nihon Rinshō Masui Gakkai shi
container_volume 9
creator ARIMA, Tadashi
OHATA, Miyoko
MATSUURA, Moto
KUROKI, Kyoko
MATSUMOTO, Isao
HORI, Takao
description We measured urinary and plasma level of prostaglandins during cardiopulmonary bypass (CPB) and their clinical significance. The urinary levels of NAG was also measured at the same time. Urinary and plasma levels of TXB2 and 6keto PGF1α were increased upon initiation of CPB. The urinary NAG level increased significantly (p
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The urinary levels of NAG was also measured at the same time. Urinary and plasma levels of TXB2 and 6keto PGF1α were increased upon initiation of CPB. The urinary NAG level increased significantly (p&lt;0.001). Plasma TXB2 levels as expected from the urinary TXB2 and 2, 3dinor-TXB2 level was higher than the measured plasma TXB2 concentration, showing increasese in TXB2 originating from the kidney. However Plasma 6ketoPGF1α as expected from the urinary 6ketoPGF1α level was same to the measured plasma 6ketoPGF1α concentration, showing no increased in 6ketoPGF1α originating from the kidney. It is possible that the elevation of urinary TXB2 level is due to the massive increase in TXA2 originating from the kidney when a hypoxic condition is indused by hypotension and lowered perfusion in the kidney, in addition to the increased excretion of platelet derived TXA2 during CPB. 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title Changes in Urinary Thromboxane Level in Man During Cardiopulmonary Bypass
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