Noncoding RNAs Serve as the Deadliest Universal Regulators of all Cancers

Numerous cancer drivers have been identified, but they are specific to a given cancer type and condition; universal cancer drivers and universal cancer mechanisms still remain largely unclear. Here, we identified the deadliest universal drivers for all cancers via developing algorithms to analyze ma...

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Veröffentlicht in:	Cancer genomics & proteomics 2021-01, Vol.18 (1), p.43-52
Hauptverfasser:	Wang, Anyou, Hai, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Antisense RNA Cancer Genomes Pseudogenes Regulators Suppressors
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container_title	Cancer genomics & proteomics
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creator	Wang, Anyou Hai, Rong
description	Numerous cancer drivers have been identified, but they are specific to a given cancer type and condition; universal cancer drivers and universal cancer mechanisms still remain largely unclear. Here, we identified the deadliest universal drivers for all cancers via developing algorithms to analyze massive RNAseqs and clinical data from The Cancer Genome Atlas (TCGA). In general, noncoding RNAs primarily serve as the most important inducers and suppressors for all types of cancers. In particular, pseudogenes are primary inducers, and specifically the antisense RNA RP11-335K5.2 serves as the most universal cancerous driver, independently of the cancer type and condition. Therefore, noncoding RNAs, instead of proteins as conventionally thought, primarily drive cancer, which establishes a novel field for future cancer research and therapy.
doi_str_mv	10.21873/cgp.20240
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subjects	Algorithms Antisense RNA Cancer Genomes Pseudogenes Regulators Suppressors
title	Noncoding RNAs Serve as the Deadliest Universal Regulators of all Cancers
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