Selective IgA deficiency in a case of systemic lupus erythematosus
A 41-year-old female with high grade fever and polyarthralgia was diagnosed as SLE from polyarthralgia, leukopenia, LE cell and high titer anti-nuclear antibody. The serum IgA level was as long as 9mg/dl and unchanged by the treatment with prednisolone, while the serum IgG and IgM were increased and...
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Veröffentlicht in: | Japanese Journal of Clinical Immunology 1986/06/30, Vol.9(3), pp.224-229 |
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creator | Ishiyama, Taijiro Abe, Sotaro Horie, Seiichi Sugaya, Naoki Wakabayashi, Yoshihisa Hirose, Shunichi |
description | A 41-year-old female with high grade fever and polyarthralgia was diagnosed as SLE from polyarthralgia, leukopenia, LE cell and high titer anti-nuclear antibody. The serum IgA level was as long as 9mg/dl and unchanged by the treatment with prednisolone, while the serum IgG and IgM were increased and responded to the treatment. The persentage of E rosette-forming lymphocytes in the peripheral blood was 79% and the persentage of surface-IgA bearing cells in non E rosette-forming cells was 20%. When PWM-induced IgA synthesis by lymphocytes from normal control and the patient were measured, the level of IgA was about a quarter of normal synthesis. Co-culture of T cells from normal control and B cells from the patient resulted in reduced synthesis of IgA. Co-culture of the patient T cells and normal B cells also resulted in reduced synthesis of IgA. Thus the pathogenesis of IgA deficiency in the patients may be due to both B cells and T cells dysfunction. |
doi_str_mv | 10.2177/jsci.9.224 |
format | Article |
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The serum IgA level was as long as 9mg/dl and unchanged by the treatment with prednisolone, while the serum IgG and IgM were increased and responded to the treatment. The persentage of E rosette-forming lymphocytes in the peripheral blood was 79% and the persentage of surface-IgA bearing cells in non E rosette-forming cells was 20%. When PWM-induced IgA synthesis by lymphocytes from normal control and the patient were measured, the level of IgA was about a quarter of normal synthesis. Co-culture of T cells from normal control and B cells from the patient resulted in reduced synthesis of IgA. Co-culture of the patient T cells and normal B cells also resulted in reduced synthesis of IgA. Thus the pathogenesis of IgA deficiency in the patients may be due to both B cells and T cells dysfunction.</description><identifier>ISSN: 0911-4300</identifier><identifier>EISSN: 1349-7413</identifier><identifier>DOI: 10.2177/jsci.9.224</identifier><language>eng</language><publisher>The Japan Society for Clinical Immunology</publisher><subject>IgA ; SLE ; T cell and B cell</subject><ispartof>Japanese Journal of Clinical Immunology, 1986/06/30, Vol.9(3), pp.224-229</ispartof><rights>The Japan Society for Clinical Immunology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>Ishiyama, Taijiro</creatorcontrib><creatorcontrib>Abe, Sotaro</creatorcontrib><creatorcontrib>Horie, Seiichi</creatorcontrib><creatorcontrib>Sugaya, Naoki</creatorcontrib><creatorcontrib>Wakabayashi, Yoshihisa</creatorcontrib><creatorcontrib>Hirose, Shunichi</creatorcontrib><title>Selective IgA deficiency in a case of systemic lupus erythematosus</title><title>Japanese Journal of Clinical Immunology</title><addtitle>Jpn. J. Clin. Immunol.</addtitle><description>A 41-year-old female with high grade fever and polyarthralgia was diagnosed as SLE from polyarthralgia, leukopenia, LE cell and high titer anti-nuclear antibody. The serum IgA level was as long as 9mg/dl and unchanged by the treatment with prednisolone, while the serum IgG and IgM were increased and responded to the treatment. The persentage of E rosette-forming lymphocytes in the peripheral blood was 79% and the persentage of surface-IgA bearing cells in non E rosette-forming cells was 20%. When PWM-induced IgA synthesis by lymphocytes from normal control and the patient were measured, the level of IgA was about a quarter of normal synthesis. Co-culture of T cells from normal control and B cells from the patient resulted in reduced synthesis of IgA. Co-culture of the patient T cells and normal B cells also resulted in reduced synthesis of IgA. Thus the pathogenesis of IgA deficiency in the patients may be due to both B cells and T cells dysfunction.</description><subject>IgA</subject><subject>SLE</subject><subject>T cell and B cell</subject><issn>0911-4300</issn><issn>1349-7413</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNo9j0tLAzEUhYMoOFY3_oKshal5NpNlW3wUCi7UdYg3d9qU6YNkRph_77SVLg53cb574CPkkbOx4MY8bzLEsR0Loa5IwaWypVFcXpOCWc5LJRm7JXc5bxiTWhpVkNknNght_EW6WE1pwDpCxB30NO6op-Az0n1Nc59b3EagTXfoMsXUt2vc-nafu3xPbmrfZHz4vyPy_fryNX8vlx9vi_l0WYLQRpUGLXBReYFotBdSVpozW-sQOIQQvPbWSAG24mGI1mg1n1gAVKr68ROQI_J03oW0zzlh7Q4pbn3qHWfuaO-O9s66wX6AZ2d4k1u_wgvqUxuhwRPKrakGXJ4yPF1KWPvkcCf_AAk2ZZc</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Ishiyama, Taijiro</creator><creator>Abe, Sotaro</creator><creator>Horie, Seiichi</creator><creator>Sugaya, Naoki</creator><creator>Wakabayashi, Yoshihisa</creator><creator>Hirose, Shunichi</creator><general>The Japan Society for Clinical Immunology</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1986</creationdate><title>Selective IgA deficiency in a case of systemic lupus erythematosus</title><author>Ishiyama, Taijiro ; Abe, Sotaro ; Horie, Seiichi ; Sugaya, Naoki ; Wakabayashi, Yoshihisa ; Hirose, Shunichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2574-7e9c128a2ee75a23385109f5dd1cddda5a9732c981d98155e95169cce448ba6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>IgA</topic><topic>SLE</topic><topic>T cell and B cell</topic><toplevel>online_resources</toplevel><creatorcontrib>Ishiyama, Taijiro</creatorcontrib><creatorcontrib>Abe, Sotaro</creatorcontrib><creatorcontrib>Horie, Seiichi</creatorcontrib><creatorcontrib>Sugaya, Naoki</creatorcontrib><creatorcontrib>Wakabayashi, Yoshihisa</creatorcontrib><creatorcontrib>Hirose, Shunichi</creatorcontrib><collection>CrossRef</collection><jtitle>Japanese Journal of Clinical Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishiyama, Taijiro</au><au>Abe, Sotaro</au><au>Horie, Seiichi</au><au>Sugaya, Naoki</au><au>Wakabayashi, Yoshihisa</au><au>Hirose, Shunichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective IgA deficiency in a case of systemic lupus erythematosus</atitle><jtitle>Japanese Journal of Clinical Immunology</jtitle><addtitle>Jpn. J. Clin. Immunol.</addtitle><date>1986</date><risdate>1986</risdate><volume>9</volume><issue>3</issue><spage>224</spage><epage>229</epage><pages>224-229</pages><issn>0911-4300</issn><eissn>1349-7413</eissn><abstract>A 41-year-old female with high grade fever and polyarthralgia was diagnosed as SLE from polyarthralgia, leukopenia, LE cell and high titer anti-nuclear antibody. The serum IgA level was as long as 9mg/dl and unchanged by the treatment with prednisolone, while the serum IgG and IgM were increased and responded to the treatment. The persentage of E rosette-forming lymphocytes in the peripheral blood was 79% and the persentage of surface-IgA bearing cells in non E rosette-forming cells was 20%. When PWM-induced IgA synthesis by lymphocytes from normal control and the patient were measured, the level of IgA was about a quarter of normal synthesis. Co-culture of T cells from normal control and B cells from the patient resulted in reduced synthesis of IgA. Co-culture of the patient T cells and normal B cells also resulted in reduced synthesis of IgA. Thus the pathogenesis of IgA deficiency in the patients may be due to both B cells and T cells dysfunction.</abstract><pub>The Japan Society for Clinical Immunology</pub><doi>10.2177/jsci.9.224</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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source | EZB-FREE-00999 freely available EZB journals |
subjects | IgA SLE T cell and B cell |
title | Selective IgA deficiency in a case of systemic lupus erythematosus |
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