Selective IgA deficiency in a case of systemic lupus erythematosus

A 41-year-old female with high grade fever and polyarthralgia was diagnosed as SLE from polyarthralgia, leukopenia, LE cell and high titer anti-nuclear antibody. The serum IgA level was as long as 9mg/dl and unchanged by the treatment with prednisolone, while the serum IgG and IgM were increased and...

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Veröffentlicht in:Japanese Journal of Clinical Immunology 1986/06/30, Vol.9(3), pp.224-229
Hauptverfasser: Ishiyama, Taijiro, Abe, Sotaro, Horie, Seiichi, Sugaya, Naoki, Wakabayashi, Yoshihisa, Hirose, Shunichi
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container_end_page 229
container_issue 3
container_start_page 224
container_title Japanese Journal of Clinical Immunology
container_volume 9
creator Ishiyama, Taijiro
Abe, Sotaro
Horie, Seiichi
Sugaya, Naoki
Wakabayashi, Yoshihisa
Hirose, Shunichi
description A 41-year-old female with high grade fever and polyarthralgia was diagnosed as SLE from polyarthralgia, leukopenia, LE cell and high titer anti-nuclear antibody. The serum IgA level was as long as 9mg/dl and unchanged by the treatment with prednisolone, while the serum IgG and IgM were increased and responded to the treatment. The persentage of E rosette-forming lymphocytes in the peripheral blood was 79% and the persentage of surface-IgA bearing cells in non E rosette-forming cells was 20%. When PWM-induced IgA synthesis by lymphocytes from normal control and the patient were measured, the level of IgA was about a quarter of normal synthesis. Co-culture of T cells from normal control and B cells from the patient resulted in reduced synthesis of IgA. Co-culture of the patient T cells and normal B cells also resulted in reduced synthesis of IgA. Thus the pathogenesis of IgA deficiency in the patients may be due to both B cells and T cells dysfunction.
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subjects IgA
SLE
T cell and B cell
title Selective IgA deficiency in a case of systemic lupus erythematosus
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