Detection of islet cell surface antibody in the thyroid disease and systemic lupus erythematosus
Islet cell surface antibody (ICSA) was examined on sera from the patients of Graves' disease, Hashimoto's thyroiditis and systemic lupus erythematosus (SLE). Five out of 22 patients (23%) of Graves' disease, 8 out of 32 patients (25%) of Hashimoto's thyroiditis and none of SLE pa...
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| Veröffentlicht in: | Japanese Journal of Clinical Immunology 1983/12/30, Vol.6(6), pp.550-554 |
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| container_title | Japanese Journal of Clinical Immunology |
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| creator | Kunihiro, Kiyoshi Yokogawa, Yasushi Ono, Junko Takaki, Ryosaburo Noguchi, Shiro Kusaba, Tomohiro |
| description | Islet cell surface antibody (ICSA) was examined on sera from the patients of Graves' disease, Hashimoto's thyroiditis and systemic lupus erythematosus (SLE). Five out of 22 patients (23%) of Graves' disease, 8 out of 32 patients (25%) of Hashimoto's thyroiditis and none of SLE patients and healthy subjects were proved to have ICSA. The incidence of ICSA was associated with the duration of the disease in Graves' disease patients (P |
| doi_str_mv | 10.2177/jsci.6.550 |
| format | Article |
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Five out of 22 patients (23%) of Graves' disease, 8 out of 32 patients (25%) of Hashimoto's thyroiditis and none of SLE patients and healthy subjects were proved to have ICSA. The incidence of ICSA was associated with the duration of the disease in Graves' disease patients (P<0.01), but had no correlation with sex, age of onset or microsome antibody (MCHA) titer. Antilymphocytotoxic antibody (ALA) was examined on sera from ICSA positive patients with high MCHA titer and SLE patients. The incidence of ALA of the former ((%) was significantly lower than that of the latter (55%) (P<0.05). These findings may suggest that plural antibodies against different endocrine organs are produced in a part of the thyroid disease and that the mechanisms of immunological disorders of such patients are different from those of SLE.</description><identifier>ISSN: 0911-4300</identifier><identifier>EISSN: 1349-7413</identifier><identifier>DOI: 10.2177/jsci.6.550</identifier><language>eng</language><publisher>The Japan Society for Clinical Immunology</publisher><subject>Graves' disease ; Hashimoto's thyroiditis ; ICSA ; SLE</subject><ispartof>Japanese Journal of Clinical Immunology, 1983/12/30, Vol.6(6), pp.550-554</ispartof><rights>The Japan Society for Clinical Immunology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>Kunihiro, Kiyoshi</creatorcontrib><creatorcontrib>Yokogawa, Yasushi</creatorcontrib><creatorcontrib>Ono, Junko</creatorcontrib><creatorcontrib>Takaki, Ryosaburo</creatorcontrib><creatorcontrib>Noguchi, Shiro</creatorcontrib><creatorcontrib>Kusaba, Tomohiro</creatorcontrib><title>Detection of islet cell surface antibody in the thyroid disease and systemic lupus erythematosus</title><title>Japanese Journal of Clinical Immunology</title><addtitle>Jpn. J. Clin. Immunol.</addtitle><description>Islet cell surface antibody (ICSA) was examined on sera from the patients of Graves' disease, Hashimoto's thyroiditis and systemic lupus erythematosus (SLE). Five out of 22 patients (23%) of Graves' disease, 8 out of 32 patients (25%) of Hashimoto's thyroiditis and none of SLE patients and healthy subjects were proved to have ICSA. The incidence of ICSA was associated with the duration of the disease in Graves' disease patients (P<0.01), but had no correlation with sex, age of onset or microsome antibody (MCHA) titer. Antilymphocytotoxic antibody (ALA) was examined on sera from ICSA positive patients with high MCHA titer and SLE patients. The incidence of ALA of the former ((%) was significantly lower than that of the latter (55%) (P<0.05). These findings may suggest that plural antibodies against different endocrine organs are produced in a part of the thyroid disease and that the mechanisms of immunological disorders of such patients are different from those of SLE.</description><subject>Graves' disease</subject><subject>Hashimoto's thyroiditis</subject><subject>ICSA</subject><subject>SLE</subject><issn>0911-4300</issn><issn>1349-7413</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><recordid>eNo9kE1PwzAMhiMEEmNw4RfkjNSRNM2SHmF8SpO47F7SxGGZunaK00P_PRlDk2X58D62rIeQe84WJVfqcYc2LJYLKdkFmXFR1YWquLgkM1ZzXlSCsWtyg7hjTEihqhn5foEENoWhp4OnATtI1ELXURyjNxao6VNoBzfR0NO0hdxTHIKjLiAYPOaO4oQJ9sHSbjyMSCFOmdybNOCIt-TKmw7h7n_OyebtdbP6KNZf75-rp3VhS6lYoaVrfc1FLXXFKq-VE6rkBrxxpWLeMQ9OG-G85tookLZuK-m5UC4_ybyYk4fTWRsHxAi-OcSwN3FqOGuOapqjmmbZZDUZfj7BO0zmB86oiSnYDv5QXiud8VPlpXNotyY20ItfLxVyCg</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Kunihiro, Kiyoshi</creator><creator>Yokogawa, Yasushi</creator><creator>Ono, Junko</creator><creator>Takaki, Ryosaburo</creator><creator>Noguchi, Shiro</creator><creator>Kusaba, Tomohiro</creator><general>The Japan Society for Clinical Immunology</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1983</creationdate><title>Detection of islet cell surface antibody in the thyroid disease and systemic lupus erythematosus</title><author>Kunihiro, Kiyoshi ; Yokogawa, Yasushi ; Ono, Junko ; Takaki, Ryosaburo ; Noguchi, Shiro ; Kusaba, Tomohiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2570-85dbf913958404f87d3721aefad270fd0fed8a3df818a7e5c9b45f137dace0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Graves' disease</topic><topic>Hashimoto's thyroiditis</topic><topic>ICSA</topic><topic>SLE</topic><toplevel>online_resources</toplevel><creatorcontrib>Kunihiro, Kiyoshi</creatorcontrib><creatorcontrib>Yokogawa, Yasushi</creatorcontrib><creatorcontrib>Ono, Junko</creatorcontrib><creatorcontrib>Takaki, Ryosaburo</creatorcontrib><creatorcontrib>Noguchi, Shiro</creatorcontrib><creatorcontrib>Kusaba, Tomohiro</creatorcontrib><collection>CrossRef</collection><jtitle>Japanese Journal of Clinical Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kunihiro, Kiyoshi</au><au>Yokogawa, Yasushi</au><au>Ono, Junko</au><au>Takaki, Ryosaburo</au><au>Noguchi, Shiro</au><au>Kusaba, Tomohiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of islet cell surface antibody in the thyroid disease and systemic lupus erythematosus</atitle><jtitle>Japanese Journal of Clinical Immunology</jtitle><addtitle>Jpn. J. Clin. Immunol.</addtitle><date>1983</date><risdate>1983</risdate><volume>6</volume><issue>6</issue><spage>550</spage><epage>554</epage><pages>550-554</pages><issn>0911-4300</issn><eissn>1349-7413</eissn><abstract>Islet cell surface antibody (ICSA) was examined on sera from the patients of Graves' disease, Hashimoto's thyroiditis and systemic lupus erythematosus (SLE). Five out of 22 patients (23%) of Graves' disease, 8 out of 32 patients (25%) of Hashimoto's thyroiditis and none of SLE patients and healthy subjects were proved to have ICSA. The incidence of ICSA was associated with the duration of the disease in Graves' disease patients (P<0.01), but had no correlation with sex, age of onset or microsome antibody (MCHA) titer. Antilymphocytotoxic antibody (ALA) was examined on sera from ICSA positive patients with high MCHA titer and SLE patients. The incidence of ALA of the former ((%) was significantly lower than that of the latter (55%) (P<0.05). These findings may suggest that plural antibodies against different endocrine organs are produced in a part of the thyroid disease and that the mechanisms of immunological disorders of such patients are different from those of SLE.</abstract><pub>The Japan Society for Clinical Immunology</pub><doi>10.2177/jsci.6.550</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0911-4300 |
| ispartof | Japanese Journal of Clinical Immunology, 1983/12/30, Vol.6(6), pp.550-554 |
| issn | 0911-4300 1349-7413 |
| language | eng |
| recordid | cdi_crossref_primary_10_2177_jsci_6_550 |
| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Graves' disease Hashimoto's thyroiditis ICSA SLE |
| title | Detection of islet cell surface antibody in the thyroid disease and systemic lupus erythematosus |
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