Normal serum concentrations of IgG subclasses in the Japanese adults
Normal values of IgG subclasses in the serum were measured by the specific monoclonal antibody-based ELISA technique with a Japanese healthy adult population (840 individuals comprising 306 male and 534 female) in their 2nd to 8th decade. The mean IgG 1 concentration in this population gradually inc...
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| Veröffentlicht in: | Japanese Journal of Clinical Immunology 1994/10/31, Vol.17(5), pp.535-545 |
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| container_title | Japanese Journal of Clinical Immunology |
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| creator | Kishimoto, Susumu Uwatoko, Shu Ito, Koji Inoue, Tetsufumi Kitamura, Kiyoshi Shimada, Kaoru Inamatsu, Takashi Sakamoto, Hiroshi Hirose, Shun-ichi Tokano, Yoshiaki Aotsuka, Shinichi Yokohari, Ryuichi Konda, Susumu Kanoh, Tadashi Kumagai, Shunich Horiuchi, Atsushi Hamada, Kinya Shimizu, Masatoshi Saeki, Osamu Ota, Zensuke Hirakawa, Shuzo Inamizu, Tsutomu Ogura, Takeshi Yamaguchi, Masaya Koga, Hironobu Kadota, Junichi Simizu, Toru Nagatomo, Midori |
| description | Normal values of IgG subclasses in the serum were measured by the specific monoclonal antibody-based ELISA technique with a Japanese healthy adult population (840 individuals comprising 306 male and 534 female) in their 2nd to 8th decade. The mean IgG 1 concentration in this population gradually increased linearily with increasing age although the mean levels of IgG 2, IgG 3 and IgG 4 showed no age-related significant variations. The percentages of individual IgG subclasses in the total IgG amount (as the sum of the four subclasses) revealed that the IgG 3 alone increased slightly with age. Possible differences in the percent composition of the IgG subclasses were sought between this population and a non-Japanese US healthy adult population. The percentages of IgG 1 and IgG 3 were approximately 8% and 2% lower but the IgG 2 was approximately 10% higher in the Japanese population than in the US population, with no significant difference in the IgG 4 between these populations. |
| doi_str_mv | 10.2177/jsci.17.535 |
| format | Article |
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The mean IgG 1 concentration in this population gradually increased linearily with increasing age although the mean levels of IgG 2, IgG 3 and IgG 4 showed no age-related significant variations. The percentages of individual IgG subclasses in the total IgG amount (as the sum of the four subclasses) revealed that the IgG 3 alone increased slightly with age. Possible differences in the percent composition of the IgG subclasses were sought between this population and a non-Japanese US healthy adult population. The percentages of IgG 1 and IgG 3 were approximately 8% and 2% lower but the IgG 2 was approximately 10% higher in the Japanese population than in the US population, with no significant difference in the IgG 4 between these populations.</description><identifier>ISSN: 0911-4300</identifier><identifier>EISSN: 1349-7413</identifier><identifier>DOI: 10.2177/jsci.17.535</identifier><language>eng</language><publisher>The Japan Society for Clinical Immunology</publisher><subject>ELISA ; IgG subclass ; normal values</subject><ispartof>Japanese Journal of Clinical Immunology, 1994/10/31, Vol.17(5), pp.535-545</ispartof><rights>The Japan Society for Clinical Immunology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3035-1209251d276de31f00fb58c1c12ad66063f30b7f5d96b8b8e4c2afce3da50b883</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4021,27921,27922,27923</link.rule.ids></links><search><creatorcontrib>Kishimoto, Susumu</creatorcontrib><creatorcontrib>Uwatoko, Shu</creatorcontrib><creatorcontrib>Ito, Koji</creatorcontrib><creatorcontrib>Inoue, Tetsufumi</creatorcontrib><creatorcontrib>Kitamura, Kiyoshi</creatorcontrib><creatorcontrib>Shimada, Kaoru</creatorcontrib><creatorcontrib>Inamatsu, Takashi</creatorcontrib><creatorcontrib>Sakamoto, Hiroshi</creatorcontrib><creatorcontrib>Hirose, Shun-ichi</creatorcontrib><creatorcontrib>Tokano, Yoshiaki</creatorcontrib><creatorcontrib>Aotsuka, Shinichi</creatorcontrib><creatorcontrib>Yokohari, Ryuichi</creatorcontrib><creatorcontrib>Konda, Susumu</creatorcontrib><creatorcontrib>Kanoh, Tadashi</creatorcontrib><creatorcontrib>Kumagai, Shunich</creatorcontrib><creatorcontrib>Horiuchi, Atsushi</creatorcontrib><creatorcontrib>Hamada, Kinya</creatorcontrib><creatorcontrib>Shimizu, Masatoshi</creatorcontrib><creatorcontrib>Saeki, Osamu</creatorcontrib><creatorcontrib>Ota, Zensuke</creatorcontrib><creatorcontrib>Hirakawa, Shuzo</creatorcontrib><creatorcontrib>Inamizu, Tsutomu</creatorcontrib><creatorcontrib>Ogura, Takeshi</creatorcontrib><creatorcontrib>Yamaguchi, Masaya</creatorcontrib><creatorcontrib>Koga, Hironobu</creatorcontrib><creatorcontrib>Kadota, Junichi</creatorcontrib><creatorcontrib>Simizu, Toru</creatorcontrib><creatorcontrib>Nagatomo, Midori</creatorcontrib><title>Normal serum concentrations of IgG subclasses in the Japanese adults</title><title>Japanese Journal of Clinical Immunology</title><addtitle>Jpn. J. Clin. Immunol.</addtitle><description>Normal values of IgG subclasses in the serum were measured by the specific monoclonal antibody-based ELISA technique with a Japanese healthy adult population (840 individuals comprising 306 male and 534 female) in their 2nd to 8th decade. The mean IgG 1 concentration in this population gradually increased linearily with increasing age although the mean levels of IgG 2, IgG 3 and IgG 4 showed no age-related significant variations. The percentages of individual IgG subclasses in the total IgG amount (as the sum of the four subclasses) revealed that the IgG 3 alone increased slightly with age. Possible differences in the percent composition of the IgG subclasses were sought between this population and a non-Japanese US healthy adult population. The percentages of IgG 1 and IgG 3 were approximately 8% and 2% lower but the IgG 2 was approximately 10% higher in the Japanese population than in the US population, with no significant difference in the IgG 4 between these populations.</description><subject>ELISA</subject><subject>IgG subclass</subject><subject>normal values</subject><issn>0911-4300</issn><issn>1349-7413</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNo9kMFOwzAMhiMEEmNw4gVyRx1x0zTtEW0whia4wLlyU2fr1LVT3B54e7oN7WIf_Pn_pU-IR1CzGKx93rGrZ2BnRpsrMQGd5JFNQF-LicoBokQrdSvumHdKaaNtMhGLzy7ssZFMYdhL17WO2j5gX3cty87L1WYpeShdg8zEsm5lvyX5gQdsiUliNTQ934sbjw3Tw_-eip-31-_5e7T-Wq7mL-vI6bEvgljlsYEqtmlFGrxSvjSZAwcxVmmqUu21Kq03VZ6WWZlR4mL0jnSFRpVZpqfi6ZzrQsccyBeHUO8x_BagiqOA4iigAFuMAkZ6caZ33OOGLiyGvnYNnVjIbXbiz2N8u5zdFkNBrf4DZThnJQ</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Kishimoto, Susumu</creator><creator>Uwatoko, Shu</creator><creator>Ito, Koji</creator><creator>Inoue, Tetsufumi</creator><creator>Kitamura, Kiyoshi</creator><creator>Shimada, Kaoru</creator><creator>Inamatsu, Takashi</creator><creator>Sakamoto, Hiroshi</creator><creator>Hirose, Shun-ichi</creator><creator>Tokano, Yoshiaki</creator><creator>Aotsuka, Shinichi</creator><creator>Yokohari, Ryuichi</creator><creator>Konda, Susumu</creator><creator>Kanoh, Tadashi</creator><creator>Kumagai, Shunich</creator><creator>Horiuchi, Atsushi</creator><creator>Hamada, Kinya</creator><creator>Shimizu, Masatoshi</creator><creator>Saeki, Osamu</creator><creator>Ota, Zensuke</creator><creator>Hirakawa, Shuzo</creator><creator>Inamizu, Tsutomu</creator><creator>Ogura, Takeshi</creator><creator>Yamaguchi, Masaya</creator><creator>Koga, Hironobu</creator><creator>Kadota, Junichi</creator><creator>Simizu, Toru</creator><creator>Nagatomo, Midori</creator><general>The Japan Society for Clinical Immunology</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1994</creationdate><title>Normal serum concentrations of IgG subclasses in the Japanese adults</title><author>Kishimoto, Susumu ; Uwatoko, Shu ; Ito, Koji ; Inoue, Tetsufumi ; Kitamura, Kiyoshi ; Shimada, Kaoru ; Inamatsu, Takashi ; Sakamoto, Hiroshi ; Hirose, Shun-ichi ; Tokano, Yoshiaki ; Aotsuka, Shinichi ; Yokohari, Ryuichi ; Konda, Susumu ; Kanoh, Tadashi ; Kumagai, Shunich ; Horiuchi, Atsushi ; Hamada, Kinya ; Shimizu, Masatoshi ; Saeki, Osamu ; Ota, Zensuke ; Hirakawa, Shuzo ; Inamizu, Tsutomu ; Ogura, Takeshi ; Yamaguchi, Masaya ; Koga, Hironobu ; Kadota, Junichi ; Simizu, Toru ; Nagatomo, Midori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3035-1209251d276de31f00fb58c1c12ad66063f30b7f5d96b8b8e4c2afce3da50b883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>ELISA</topic><topic>IgG subclass</topic><topic>normal values</topic><toplevel>online_resources</toplevel><creatorcontrib>Kishimoto, Susumu</creatorcontrib><creatorcontrib>Uwatoko, Shu</creatorcontrib><creatorcontrib>Ito, Koji</creatorcontrib><creatorcontrib>Inoue, Tetsufumi</creatorcontrib><creatorcontrib>Kitamura, Kiyoshi</creatorcontrib><creatorcontrib>Shimada, Kaoru</creatorcontrib><creatorcontrib>Inamatsu, Takashi</creatorcontrib><creatorcontrib>Sakamoto, Hiroshi</creatorcontrib><creatorcontrib>Hirose, Shun-ichi</creatorcontrib><creatorcontrib>Tokano, Yoshiaki</creatorcontrib><creatorcontrib>Aotsuka, Shinichi</creatorcontrib><creatorcontrib>Yokohari, Ryuichi</creatorcontrib><creatorcontrib>Konda, Susumu</creatorcontrib><creatorcontrib>Kanoh, Tadashi</creatorcontrib><creatorcontrib>Kumagai, Shunich</creatorcontrib><creatorcontrib>Horiuchi, Atsushi</creatorcontrib><creatorcontrib>Hamada, Kinya</creatorcontrib><creatorcontrib>Shimizu, Masatoshi</creatorcontrib><creatorcontrib>Saeki, Osamu</creatorcontrib><creatorcontrib>Ota, Zensuke</creatorcontrib><creatorcontrib>Hirakawa, Shuzo</creatorcontrib><creatorcontrib>Inamizu, Tsutomu</creatorcontrib><creatorcontrib>Ogura, Takeshi</creatorcontrib><creatorcontrib>Yamaguchi, Masaya</creatorcontrib><creatorcontrib>Koga, Hironobu</creatorcontrib><creatorcontrib>Kadota, Junichi</creatorcontrib><creatorcontrib>Simizu, Toru</creatorcontrib><creatorcontrib>Nagatomo, Midori</creatorcontrib><collection>CrossRef</collection><jtitle>Japanese Journal of Clinical Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kishimoto, Susumu</au><au>Uwatoko, Shu</au><au>Ito, Koji</au><au>Inoue, Tetsufumi</au><au>Kitamura, Kiyoshi</au><au>Shimada, Kaoru</au><au>Inamatsu, Takashi</au><au>Sakamoto, Hiroshi</au><au>Hirose, Shun-ichi</au><au>Tokano, Yoshiaki</au><au>Aotsuka, Shinichi</au><au>Yokohari, Ryuichi</au><au>Konda, Susumu</au><au>Kanoh, Tadashi</au><au>Kumagai, Shunich</au><au>Horiuchi, Atsushi</au><au>Hamada, Kinya</au><au>Shimizu, Masatoshi</au><au>Saeki, Osamu</au><au>Ota, Zensuke</au><au>Hirakawa, Shuzo</au><au>Inamizu, Tsutomu</au><au>Ogura, Takeshi</au><au>Yamaguchi, Masaya</au><au>Koga, Hironobu</au><au>Kadota, Junichi</au><au>Simizu, Toru</au><au>Nagatomo, Midori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal serum concentrations of IgG subclasses in the Japanese adults</atitle><jtitle>Japanese Journal of Clinical Immunology</jtitle><addtitle>Jpn. J. Clin. Immunol.</addtitle><date>1994</date><risdate>1994</risdate><volume>17</volume><issue>5</issue><spage>535</spage><epage>545</epage><pages>535-545</pages><issn>0911-4300</issn><eissn>1349-7413</eissn><abstract>Normal values of IgG subclasses in the serum were measured by the specific monoclonal antibody-based ELISA technique with a Japanese healthy adult population (840 individuals comprising 306 male and 534 female) in their 2nd to 8th decade. The mean IgG 1 concentration in this population gradually increased linearily with increasing age although the mean levels of IgG 2, IgG 3 and IgG 4 showed no age-related significant variations. The percentages of individual IgG subclasses in the total IgG amount (as the sum of the four subclasses) revealed that the IgG 3 alone increased slightly with age. Possible differences in the percent composition of the IgG subclasses were sought between this population and a non-Japanese US healthy adult population. The percentages of IgG 1 and IgG 3 were approximately 8% and 2% lower but the IgG 2 was approximately 10% higher in the Japanese population than in the US population, with no significant difference in the IgG 4 between these populations.</abstract><pub>The Japan Society for Clinical Immunology</pub><doi>10.2177/jsci.17.535</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Japanese Journal of Clinical Immunology, 1994/10/31, Vol.17(5), pp.535-545 |
| issn | 0911-4300 1349-7413 |
| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | ELISA IgG subclass normal values |
| title | Normal serum concentrations of IgG subclasses in the Japanese adults |
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