Pilocytic Astrocytoma With Histological Malignant Features Without Previous Radiation Therapy: Case Report
Pilocytic astrocytoma sometimes transforms to a malignant type, and previous radiation therapy is considered to be a key factor. We report a case of pilocytic astrocytoma with histological malignant features without previous radiation therapy. A 21-year-old man presented a sudden onset of severe hea...
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| Veröffentlicht in: | Neurologia medico-chirurgica 2011, Vol.51(2), pp.144-147 |
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| creator | SHIBAHARA, Ichiyo KAWAGUCHI, Tomohiro KANAMORI, Masayuki YONEZAWA, Shingo TAKAZAWA, Hiroki ASANO, Kenichiro OHKUMA, Hiroki KAIMORI, Mitsuomi SASAKI, Tatsuya NISHIJIMA, Michiharu |
| description | Pilocytic astrocytoma sometimes transforms to a malignant type, and previous radiation therapy is considered to be a key factor. We report a case of pilocytic astrocytoma with histological malignant features without previous radiation therapy. A 21-year-old man presented a sudden onset of severe headache. Neuroimaging had detected a cystic mass in the posterior fossa at the age of one year without therapeutic intervention. On admission, computed tomography depicted a brain tumor in the posterior fossa with cystic components, intratumoral hemorrhage, and upward herniation. Urgent surgery was performed, and histological examination revealed some features of pilocytic astrocytoma but also broad necrosis, high cellularity, and MIB-1 labeling index of more than 20%. The histological diagnosis was pilocytic astrocytoma with malignant features. This tumor had continued a benign clinical course for 20 years, but had eventually transformed to a malignant type. Therefore, pilocytic astrocytoma may undergo spontaneous malignant transformation during its natural clinical course. |
| doi_str_mv | 10.2176/nmc.51.144 |
| format | Article |
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We report a case of pilocytic astrocytoma with histological malignant features without previous radiation therapy. A 21-year-old man presented a sudden onset of severe headache. Neuroimaging had detected a cystic mass in the posterior fossa at the age of one year without therapeutic intervention. On admission, computed tomography depicted a brain tumor in the posterior fossa with cystic components, intratumoral hemorrhage, and upward herniation. Urgent surgery was performed, and histological examination revealed some features of pilocytic astrocytoma but also broad necrosis, high cellularity, and MIB-1 labeling index of more than 20%. The histological diagnosis was pilocytic astrocytoma with malignant features. This tumor had continued a benign clinical course for 20 years, but had eventually transformed to a malignant type. 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This tumor had continued a benign clinical course for 20 years, but had eventually transformed to a malignant type. Therefore, pilocytic astrocytoma may undergo spontaneous malignant transformation during its natural clinical course.</description><subject>Age of Onset</subject><subject>Antineoplastic Protocols - standards</subject><subject>Astrocytoma - pathology</subject><subject>Astrocytoma - physiopathology</subject><subject>Astrocytoma - therapy</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Cerebellar Neoplasms - pathology</subject><subject>Cerebellar Neoplasms - physiopathology</subject><subject>Cerebellar Neoplasms - therapy</subject><subject>Cerebellum - pathology</subject><subject>Cerebellum - physiopathology</subject><subject>Cerebellum - surgery</subject><subject>Humans</subject><subject>Male</subject><subject>malignant transformation</subject><subject>pathology</subject><subject>pilocytic astrocytoma</subject><subject>radiation therapy</subject><subject>Young Adult</subject><issn>0470-8105</issn><issn>1349-8029</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFLwzAUgIMobsxd_AHSs9CZNEmbnGQM54SJQyaepLymyRbp2pGkwv69nXW7vPfgfXyHD6FbgicJydKHeqcmnEwIYxdoSCiTscCJvERDzDIcC4L5AI29twXGCROMiuwaDRJCuSApGaKvla0adQhWRVMf3PFsdhB92rCNFtaHpmo2VkEVvUJlNzXUIZprCK3T_g9q2hCtnP6xTeujdygtBNvU0XqrHewPN-jKQOX1-H-P0Mf8aT1bxMu355fZdBkrRnGIgXJJGadCckWVSpSUouSp1lirVBZMK1kYUJyk1IAwBgudmUylJSRGFljQEbrvvco13jtt8r2zO3CHnOD8mCnvMuWc5F2mDr7r4X1b7HR5Rk9ROuCxB759gI0-A-C6TJU-uZJ-dMrzR23B5bqmv4RmfHM</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>SHIBAHARA, Ichiyo</creator><creator>KAWAGUCHI, Tomohiro</creator><creator>KANAMORI, Masayuki</creator><creator>YONEZAWA, Shingo</creator><creator>TAKAZAWA, Hiroki</creator><creator>ASANO, Kenichiro</creator><creator>OHKUMA, Hiroki</creator><creator>KAIMORI, Mitsuomi</creator><creator>SASAKI, Tatsuya</creator><creator>NISHIJIMA, Michiharu</creator><general>The Japan Neurosurgical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2011</creationdate><title>Pilocytic Astrocytoma With Histological Malignant Features Without Previous Radiation Therapy</title><author>SHIBAHARA, Ichiyo ; KAWAGUCHI, Tomohiro ; KANAMORI, Masayuki ; YONEZAWA, Shingo ; TAKAZAWA, Hiroki ; ASANO, Kenichiro ; OHKUMA, Hiroki ; KAIMORI, Mitsuomi ; SASAKI, Tatsuya ; NISHIJIMA, Michiharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-a3593453895c3cc2c998d56ee0ec69b4ec9bfac5163fa8ff08e7f7c6da2f9b083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age of Onset</topic><topic>Antineoplastic Protocols - standards</topic><topic>Astrocytoma - pathology</topic><topic>Astrocytoma - physiopathology</topic><topic>Astrocytoma - therapy</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Cerebellar Neoplasms - pathology</topic><topic>Cerebellar Neoplasms - physiopathology</topic><topic>Cerebellar Neoplasms - therapy</topic><topic>Cerebellum - pathology</topic><topic>Cerebellum - physiopathology</topic><topic>Cerebellum - surgery</topic><topic>Humans</topic><topic>Male</topic><topic>malignant transformation</topic><topic>pathology</topic><topic>pilocytic astrocytoma</topic><topic>radiation therapy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHIBAHARA, Ichiyo</creatorcontrib><creatorcontrib>KAWAGUCHI, Tomohiro</creatorcontrib><creatorcontrib>KANAMORI, Masayuki</creatorcontrib><creatorcontrib>YONEZAWA, Shingo</creatorcontrib><creatorcontrib>TAKAZAWA, Hiroki</creatorcontrib><creatorcontrib>ASANO, Kenichiro</creatorcontrib><creatorcontrib>OHKUMA, Hiroki</creatorcontrib><creatorcontrib>KAIMORI, Mitsuomi</creatorcontrib><creatorcontrib>SASAKI, Tatsuya</creatorcontrib><creatorcontrib>NISHIJIMA, Michiharu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Neurologia medico-chirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIBAHARA, Ichiyo</au><au>KAWAGUCHI, Tomohiro</au><au>KANAMORI, Masayuki</au><au>YONEZAWA, Shingo</au><au>TAKAZAWA, Hiroki</au><au>ASANO, Kenichiro</au><au>OHKUMA, Hiroki</au><au>KAIMORI, Mitsuomi</au><au>SASAKI, Tatsuya</au><au>NISHIJIMA, Michiharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pilocytic Astrocytoma With Histological Malignant Features Without Previous Radiation Therapy: Case Report</atitle><jtitle>Neurologia medico-chirurgica</jtitle><addtitle>Neurol. Med. Chir.(Tokyo)</addtitle><date>2011</date><risdate>2011</risdate><volume>51</volume><issue>2</issue><spage>144</spage><epage>147</epage><pages>144-147</pages><issn>0470-8105</issn><eissn>1349-8029</eissn><abstract>Pilocytic astrocytoma sometimes transforms to a malignant type, and previous radiation therapy is considered to be a key factor. We report a case of pilocytic astrocytoma with histological malignant features without previous radiation therapy. A 21-year-old man presented a sudden onset of severe headache. Neuroimaging had detected a cystic mass in the posterior fossa at the age of one year without therapeutic intervention. On admission, computed tomography depicted a brain tumor in the posterior fossa with cystic components, intratumoral hemorrhage, and upward herniation. Urgent surgery was performed, and histological examination revealed some features of pilocytic astrocytoma but also broad necrosis, high cellularity, and MIB-1 labeling index of more than 20%. 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| subjects | Age of Onset Antineoplastic Protocols - standards Astrocytoma - pathology Astrocytoma - physiopathology Astrocytoma - therapy Cell Transformation, Neoplastic - pathology Cerebellar Neoplasms - pathology Cerebellar Neoplasms - physiopathology Cerebellar Neoplasms - therapy Cerebellum - pathology Cerebellum - physiopathology Cerebellum - surgery Humans Male malignant transformation pathology pilocytic astrocytoma radiation therapy Young Adult |
| title | Pilocytic Astrocytoma With Histological Malignant Features Without Previous Radiation Therapy: Case Report |
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