Refractory Recurrent Thymoma Successfully Treated with Long-acting Somatostatin Analogue and Prednisolone
The patient was 54-year-old woman diagnosed as recurrent invasive thymoma (typeB3; WHO classification). Although partial response was obtained by systemic chemotherapy (PAC: cisplatin, doxorubicin, cyclophosphamide), the tumor started to become enlarged after cessation of chemotherapy. Combined trea...
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| Veröffentlicht in: | Internal Medicine 2009, Vol.48(12), pp.1061-1064 |
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| container_issue | 12 |
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| container_title | Internal Medicine |
| container_volume | 48 |
| creator | Ito, Jun Sekiya, Mitsuaki Miura, Kayo Yoshimi, Kaku Suzuki, Tsutomu Seyama, Kuniaki Izumi, Hiroshi Uekusa, Toshimasa Takahashi, Kazuhisa |
| description | The patient was 54-year-old woman diagnosed as recurrent invasive thymoma (typeB3; WHO classification). Although partial response was obtained by systemic chemotherapy (PAC: cisplatin, doxorubicin, cyclophosphamide), the tumor started to become enlarged after cessation of chemotherapy. Combined treatment of octreotide and prednisolone was administrated because various chemotherapies, including PAC, were not effective. After seven months, the tumor size was markedly decreased. The combination of octreotide and prednisolone should be considered as one of the choices of treatment in patients with recurrent thymoma. |
| doi_str_mv | 10.2169/internalmedicine.48.1922 |
| format | Article |
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Although partial response was obtained by systemic chemotherapy (PAC: cisplatin, doxorubicin, cyclophosphamide), the tumor started to become enlarged after cessation of chemotherapy. Combined treatment of octreotide and prednisolone was administrated because various chemotherapies, including PAC, were not effective. After seven months, the tumor size was markedly decreased. The combination of octreotide and prednisolone should be considered as one of the choices of treatment in patients with recurrent thymoma.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.48.1922</identifier><identifier>PMID: 19525599</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Antineoplastic Agents, Hormonal - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Cisplatin - administration & dosage ; Cyclophosphamide - administration & dosage ; Doxorubicin - administration & dosage ; Drug Therapy, Combination ; Female ; Humans ; Middle Aged ; Neoplasm Recurrence, Local - drug therapy ; octreotide ; Octreotide - therapeutic use ; prednisolone ; Prednisolone - therapeutic use ; Somatostatin - analogs & derivatives ; somatostatin analogue ; thymoma ; Thymoma - drug therapy ; Thymus Neoplasms - drug therapy ; Treatment Outcome</subject><ispartof>Internal Medicine, 2009, Vol.48(12), pp.1061-1064</ispartof><rights>2009 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-dfb9460b37cfba89e4bd1468fcfea274d13d26c317a2c24c5242d20a3baa17223</citedby><cites>FETCH-LOGICAL-c475t-dfb9460b37cfba89e4bd1468fcfea274d13d26c317a2c24c5242d20a3baa17223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19525599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Jun</creatorcontrib><creatorcontrib>Sekiya, Mitsuaki</creatorcontrib><creatorcontrib>Miura, Kayo</creatorcontrib><creatorcontrib>Yoshimi, Kaku</creatorcontrib><creatorcontrib>Suzuki, Tsutomu</creatorcontrib><creatorcontrib>Seyama, Kuniaki</creatorcontrib><creatorcontrib>Izumi, Hiroshi</creatorcontrib><creatorcontrib>Uekusa, Toshimasa</creatorcontrib><creatorcontrib>Takahashi, Kazuhisa</creatorcontrib><title>Refractory Recurrent Thymoma Successfully Treated with Long-acting Somatostatin Analogue and Prednisolone</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>The patient was 54-year-old woman diagnosed as recurrent invasive thymoma (typeB3; WHO classification). Although partial response was obtained by systemic chemotherapy (PAC: cisplatin, doxorubicin, cyclophosphamide), the tumor started to become enlarged after cessation of chemotherapy. Combined treatment of octreotide and prednisolone was administrated because various chemotherapies, including PAC, were not effective. After seven months, the tumor size was markedly decreased. The combination of octreotide and prednisolone should be considered as one of the choices of treatment in patients with recurrent thymoma.</description><subject>Antineoplastic Agents, Hormonal - therapeutic use</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Cisplatin - administration & dosage</subject><subject>Cyclophosphamide - administration & dosage</subject><subject>Doxorubicin - administration & dosage</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - drug therapy</subject><subject>octreotide</subject><subject>Octreotide - therapeutic use</subject><subject>prednisolone</subject><subject>Prednisolone - therapeutic use</subject><subject>Somatostatin - analogs & derivatives</subject><subject>somatostatin analogue</subject><subject>thymoma</subject><subject>Thymoma - drug therapy</subject><subject>Thymus Neoplasms - drug therapy</subject><subject>Treatment Outcome</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkNtKAzEQhoMoWg-vIHmBrZtJ9pBLKZ6goNR6vWST2TayzZYki_TtTWlREG9mGOb7f2Z-QijLp8BKeWddRO9Uv0FjtXU4FfWUSYATMmFcyKwCXpySSS5ZnUEqF-QyhM8853Ul4ZxcMFlAUUg5IXaBnVc6Dn5HF6hH79FFulzvNsNG0fdRawyhG_t-R5ceVURDv2xc0_ngVlnSWbei7wmNQ4gqTfQ-nTWsRqTKGfrm0Tgbhn5weE3OOtUHvDn2K_Lx-LCcPWfz16eX2f0806IqYma6Vooyb3mlu1bVEkVrmCjrTneooBKGcQOl5qxSoEHoAgQYyBVvlWIVAL8i9cFX-yEEj12z9Xaj_K5hebNPr_mbXiPqZp9ekt4epNuxTctf4TGuBLwegM_07Qp_AOWj1T3-7wzHyvKS_ZB6rXyDjn8Dk3aRWA</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Ito, Jun</creator><creator>Sekiya, Mitsuaki</creator><creator>Miura, Kayo</creator><creator>Yoshimi, Kaku</creator><creator>Suzuki, Tsutomu</creator><creator>Seyama, Kuniaki</creator><creator>Izumi, Hiroshi</creator><creator>Uekusa, Toshimasa</creator><creator>Takahashi, Kazuhisa</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20090101</creationdate><title>Refractory Recurrent Thymoma Successfully Treated with Long-acting Somatostatin Analogue and Prednisolone</title><author>Ito, Jun ; Sekiya, Mitsuaki ; Miura, Kayo ; Yoshimi, Kaku ; Suzuki, Tsutomu ; Seyama, Kuniaki ; Izumi, Hiroshi ; Uekusa, Toshimasa ; Takahashi, Kazuhisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-dfb9460b37cfba89e4bd1468fcfea274d13d26c317a2c24c5242d20a3baa17223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Antineoplastic Agents, Hormonal - therapeutic use</topic><topic>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Cisplatin - administration & dosage</topic><topic>Cyclophosphamide - administration & dosage</topic><topic>Doxorubicin - administration & dosage</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - drug therapy</topic><topic>octreotide</topic><topic>Octreotide - therapeutic use</topic><topic>prednisolone</topic><topic>Prednisolone - therapeutic use</topic><topic>Somatostatin - analogs & derivatives</topic><topic>somatostatin analogue</topic><topic>thymoma</topic><topic>Thymoma - drug therapy</topic><topic>Thymus Neoplasms - drug therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Jun</creatorcontrib><creatorcontrib>Sekiya, Mitsuaki</creatorcontrib><creatorcontrib>Miura, Kayo</creatorcontrib><creatorcontrib>Yoshimi, Kaku</creatorcontrib><creatorcontrib>Suzuki, Tsutomu</creatorcontrib><creatorcontrib>Seyama, Kuniaki</creatorcontrib><creatorcontrib>Izumi, Hiroshi</creatorcontrib><creatorcontrib>Uekusa, Toshimasa</creatorcontrib><creatorcontrib>Takahashi, Kazuhisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Jun</au><au>Sekiya, Mitsuaki</au><au>Miura, Kayo</au><au>Yoshimi, Kaku</au><au>Suzuki, Tsutomu</au><au>Seyama, Kuniaki</au><au>Izumi, Hiroshi</au><au>Uekusa, Toshimasa</au><au>Takahashi, Kazuhisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Refractory Recurrent Thymoma Successfully Treated with Long-acting Somatostatin Analogue and Prednisolone</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>48</volume><issue>12</issue><spage>1061</spage><epage>1064</epage><pages>1061-1064</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>The patient was 54-year-old woman diagnosed as recurrent invasive thymoma (typeB3; WHO classification). Although partial response was obtained by systemic chemotherapy (PAC: cisplatin, doxorubicin, cyclophosphamide), the tumor started to become enlarged after cessation of chemotherapy. Combined treatment of octreotide and prednisolone was administrated because various chemotherapies, including PAC, were not effective. After seven months, the tumor size was markedly decreased. The combination of octreotide and prednisolone should be considered as one of the choices of treatment in patients with recurrent thymoma.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>19525599</pmid><doi>10.2169/internalmedicine.48.1922</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Internal Medicine, 2009, Vol.48(12), pp.1061-1064 |
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| language | eng |
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| source | J-STAGE Free; MEDLINE |
| subjects | Antineoplastic Agents, Hormonal - therapeutic use Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cisplatin - administration & dosage Cyclophosphamide - administration & dosage Doxorubicin - administration & dosage Drug Therapy, Combination Female Humans Middle Aged Neoplasm Recurrence, Local - drug therapy octreotide Octreotide - therapeutic use prednisolone Prednisolone - therapeutic use Somatostatin - analogs & derivatives somatostatin analogue thymoma Thymoma - drug therapy Thymus Neoplasms - drug therapy Treatment Outcome |
| title | Refractory Recurrent Thymoma Successfully Treated with Long-acting Somatostatin Analogue and Prednisolone |
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