Motor Neuron Involvement in a Patient with Long-term Corticosteroid Administration
An asthmatic patient with corticosteroid treatment for 45 years presented with slowly progressive limb muscle atrophy. His muscle symptoms were involved in four limbs and tongue, and deep tendon reflexes were exaggerated. Biopsied muscle pathology indicated the presence of neurogenic muscular atroph...
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| Veröffentlicht in: | Internal Medicine 2003, Vol.42(9), pp.862-866 |
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| container_title | Internal Medicine |
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| creator | MTSUI, Takao UMAKI, Yoshifumi NAGASAWA, Masakazu AKAIKE, Masashi OHTSUKA, Satoshi ODOMI, Masaaki AKI, Kenji MATSUMOTO, Toshio |
| description | An asthmatic patient with corticosteroid treatment for 45 years presented with slowly progressive limb muscle atrophy. His muscle symptoms were involved in four limbs and tongue, and deep tendon reflexes were exaggerated. Biopsied muscle pathology indicated the presence of neurogenic muscular atrophy in combination with corticosteroid myopathy. Furthermore, 8-hydroxy-deoxyguanosine (8-OH-dG) was prominently increased in mitochondrial and nuclear DNA. An aerobic exercise test demonstrated remarkable serum lactate elevation, which was attenuated by the administration of coenzyme Q10- These findings are consistent with the assumption that long-term corticosteroid administration potentially induces not only myopathy but also motor neuron involvement as in mitochondrial diseases. (Internal Medicine 42: 862-866, 2003) |
| doi_str_mv | 10.2169/internalmedicine.42.862 |
| format | Article |
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His muscle symptoms were involved in four limbs and tongue, and deep tendon reflexes were exaggerated. Biopsied muscle pathology indicated the presence of neurogenic muscular atrophy in combination with corticosteroid myopathy. Furthermore, 8-hydroxy-deoxyguanosine (8-OH-dG) was prominently increased in mitochondrial and nuclear DNA. An aerobic exercise test demonstrated remarkable serum lactate elevation, which was attenuated by the administration of coenzyme Q10- These findings are consistent with the assumption that long-term corticosteroid administration potentially induces not only myopathy but also motor neuron involvement as in mitochondrial diseases. (Internal Medicine 42: 862-866, 2003)</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.42.862</identifier><identifier>PMID: 14518677</identifier><language>eng</language><publisher>Tokyo: The Japanese Society of Internal Medicine</publisher><subject>Aged ; asthma ; Asthma - drug therapy ; Betamethasone - adverse effects ; Biological and medical sciences ; Biopsy ; corticosteroid myopathy ; denervation ; Drug toxicity and drugs side effects treatment ; Electromyography ; Glucocorticoids - adverse effects ; Humans ; Male ; Medical sciences ; mitochondria ; Mitochondria, Muscle - drug effects ; Mitochondrial Myopathies - chemically induced ; Mitochondrial Myopathies - diagnosis ; Mitochondrial Myopathies - metabolism ; Motor Neuron Disease - chemically induced ; Motor Neuron Disease - diagnosis ; Motor Neuron Disease - metabolism ; Muscle, Skeletal - innervation ; Muscle, Skeletal - pathology ; Muscular Atrophy - chemically induced ; Muscular Atrophy - pathology ; Muscular Atrophy - physiopathology ; neurogenic muscular atrophy ; Oxidative Stress - physiology ; Pharmacology. Drug treatments ; Toxicity: nervous system and muscle</subject><ispartof>Internal Medicine, 2003, Vol.42(9), pp.862-866</ispartof><rights>The Japanese Society of Internal Medicine</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-6e60b966bf19d448d222dfdb170da4d2c341739533d6b3befe7e87b4dae2a5543</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15288708$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14518677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MTSUI, Takao</creatorcontrib><creatorcontrib>UMAKI, Yoshifumi</creatorcontrib><creatorcontrib>NAGASAWA, Masakazu</creatorcontrib><creatorcontrib>AKAIKE, Masashi</creatorcontrib><creatorcontrib>OHTSUKA, Satoshi</creatorcontrib><creatorcontrib>ODOMI, Masaaki</creatorcontrib><creatorcontrib>AKI, Kenji</creatorcontrib><creatorcontrib>MATSUMOTO, Toshio</creatorcontrib><title>Motor Neuron Involvement in a Patient with Long-term Corticosteroid Administration</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>An asthmatic patient with corticosteroid treatment for 45 years presented with slowly progressive limb muscle atrophy. His muscle symptoms were involved in four limbs and tongue, and deep tendon reflexes were exaggerated. Biopsied muscle pathology indicated the presence of neurogenic muscular atrophy in combination with corticosteroid myopathy. Furthermore, 8-hydroxy-deoxyguanosine (8-OH-dG) was prominently increased in mitochondrial and nuclear DNA. An aerobic exercise test demonstrated remarkable serum lactate elevation, which was attenuated by the administration of coenzyme Q10- These findings are consistent with the assumption that long-term corticosteroid administration potentially induces not only myopathy but also motor neuron involvement as in mitochondrial diseases. (Internal Medicine 42: 862-866, 2003)</description><subject>Aged</subject><subject>asthma</subject><subject>Asthma - drug therapy</subject><subject>Betamethasone - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>corticosteroid myopathy</subject><subject>denervation</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Electromyography</subject><subject>Glucocorticoids - adverse effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>mitochondria</subject><subject>Mitochondria, Muscle - drug effects</subject><subject>Mitochondrial Myopathies - chemically induced</subject><subject>Mitochondrial Myopathies - diagnosis</subject><subject>Mitochondrial Myopathies - metabolism</subject><subject>Motor Neuron Disease - chemically induced</subject><subject>Motor Neuron Disease - diagnosis</subject><subject>Motor Neuron Disease - metabolism</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscular Atrophy - chemically induced</subject><subject>Muscular Atrophy - pathology</subject><subject>Muscular Atrophy - physiopathology</subject><subject>neurogenic muscular atrophy</subject><subject>Oxidative Stress - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: nervous system and muscle</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkFtLwzAYhoMobk7_gvbGy87m0Ca5HMPDYOoQvS5pk24ZbTKSbOK_N2VjA735wkeeN3l5ALiD2RjBgj9oE5Qzou2U1LU2akzQmBXoDAwhJjylCOfnYJhxyFIUxwBceb_OMswoR5dgAEkOWUHpEHy82mBd8qa2zppkZna23alOmZBok4hkIYLul28dVsncmmUa_-2SqXVB19bHxWqZTGSnjfbBRdqaa3DRiNarm8M5Al9Pj5_Tl3T-_jybTuZpnecwpIUqsooXRdVALglhEiEkG1lBmklBJKoxgRTzHGNZVLhSjaKK0YpIoZDIc4JHgO7frZ313qmm3DjdCfdTwqzsLZV_LZUEldFSTN7uk5ttFe9OuYOWCNwfAOFr0TZOmFr7E5cjxmjGIrfYc2sfxFIdAdHradW_ApBz1Jfg-xG7HNF6JVypDP4F7E-UxA</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>MTSUI, Takao</creator><creator>UMAKI, Yoshifumi</creator><creator>NAGASAWA, Masakazu</creator><creator>AKAIKE, Masashi</creator><creator>OHTSUKA, Satoshi</creator><creator>ODOMI, Masaaki</creator><creator>AKI, Kenji</creator><creator>MATSUMOTO, Toshio</creator><general>The Japanese Society of Internal Medicine</general><general>Japanese Society of Internal Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20030901</creationdate><title>Motor Neuron Involvement in a Patient with Long-term Corticosteroid Administration</title><author>MTSUI, Takao ; UMAKI, Yoshifumi ; NAGASAWA, Masakazu ; AKAIKE, Masashi ; OHTSUKA, Satoshi ; ODOMI, Masaaki ; AKI, Kenji ; MATSUMOTO, Toshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-6e60b966bf19d448d222dfdb170da4d2c341739533d6b3befe7e87b4dae2a5543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>asthma</topic><topic>Asthma - drug therapy</topic><topic>Betamethasone - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>corticosteroid myopathy</topic><topic>denervation</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Electromyography</topic><topic>Glucocorticoids - adverse effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>mitochondria</topic><topic>Mitochondria, Muscle - drug effects</topic><topic>Mitochondrial Myopathies - chemically induced</topic><topic>Mitochondrial Myopathies - diagnosis</topic><topic>Mitochondrial Myopathies - metabolism</topic><topic>Motor Neuron Disease - chemically induced</topic><topic>Motor Neuron Disease - diagnosis</topic><topic>Motor Neuron Disease - metabolism</topic><topic>Muscle, Skeletal - innervation</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscular Atrophy - chemically induced</topic><topic>Muscular Atrophy - pathology</topic><topic>Muscular Atrophy - physiopathology</topic><topic>neurogenic muscular atrophy</topic><topic>Oxidative Stress - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Toxicity: nervous system and muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MTSUI, Takao</creatorcontrib><creatorcontrib>UMAKI, Yoshifumi</creatorcontrib><creatorcontrib>NAGASAWA, Masakazu</creatorcontrib><creatorcontrib>AKAIKE, Masashi</creatorcontrib><creatorcontrib>OHTSUKA, Satoshi</creatorcontrib><creatorcontrib>ODOMI, Masaaki</creatorcontrib><creatorcontrib>AKI, Kenji</creatorcontrib><creatorcontrib>MATSUMOTO, Toshio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MTSUI, Takao</au><au>UMAKI, Yoshifumi</au><au>NAGASAWA, Masakazu</au><au>AKAIKE, Masashi</au><au>OHTSUKA, Satoshi</au><au>ODOMI, Masaaki</au><au>AKI, Kenji</au><au>MATSUMOTO, Toshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Motor Neuron Involvement in a Patient with Long-term Corticosteroid Administration</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>42</volume><issue>9</issue><spage>862</spage><epage>866</epage><pages>862-866</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>An asthmatic patient with corticosteroid treatment for 45 years presented with slowly progressive limb muscle atrophy. His muscle symptoms were involved in four limbs and tongue, and deep tendon reflexes were exaggerated. Biopsied muscle pathology indicated the presence of neurogenic muscular atrophy in combination with corticosteroid myopathy. Furthermore, 8-hydroxy-deoxyguanosine (8-OH-dG) was prominently increased in mitochondrial and nuclear DNA. An aerobic exercise test demonstrated remarkable serum lactate elevation, which was attenuated by the administration of coenzyme Q10- These findings are consistent with the assumption that long-term corticosteroid administration potentially induces not only myopathy but also motor neuron involvement as in mitochondrial diseases. (Internal Medicine 42: 862-866, 2003)</abstract><cop>Tokyo</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>14518677</pmid><doi>10.2169/internalmedicine.42.862</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Internal Medicine, 2003, Vol.42(9), pp.862-866 |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged asthma Asthma - drug therapy Betamethasone - adverse effects Biological and medical sciences Biopsy corticosteroid myopathy denervation Drug toxicity and drugs side effects treatment Electromyography Glucocorticoids - adverse effects Humans Male Medical sciences mitochondria Mitochondria, Muscle - drug effects Mitochondrial Myopathies - chemically induced Mitochondrial Myopathies - diagnosis Mitochondrial Myopathies - metabolism Motor Neuron Disease - chemically induced Motor Neuron Disease - diagnosis Motor Neuron Disease - metabolism Muscle, Skeletal - innervation Muscle, Skeletal - pathology Muscular Atrophy - chemically induced Muscular Atrophy - pathology Muscular Atrophy - physiopathology neurogenic muscular atrophy Oxidative Stress - physiology Pharmacology. Drug treatments Toxicity: nervous system and muscle |
| title | Motor Neuron Involvement in a Patient with Long-term Corticosteroid Administration |
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