Hepatic Veno-Occlusive Disease in a Case of Polymyositis Associated with Thrombotic Thrombocytopenic Purpura/hemolytic Uremic Syndrome
A 50-year-old woman was treated with prednisolone for polymyositis. During the therapy, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) occurred. Neither plasma infusion nor plasma exchange could relieve the clinical manifestations of TTP/HUS. Moreover, massive ascites appear...
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| Veröffentlicht in: | Internal Medicine 1998, Vol.37(8), pp.694-699 |
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| container_title | Internal Medicine |
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| creator | ISHIDA, Yoh-ichi UTIKOSHI, Manabu KUROSAKI, Masao OHTA, Katuroh CHUJO, Tatsuya AOYAMA, Shou OHSAWA, Kenzo SAITO, Katsuhiko YOKOYAMA, Hitoshi OHTA, Satoshi |
| description | A 50-year-old woman was treated with prednisolone for polymyositis. During the therapy, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) occurred. Neither plasma infusion nor plasma exchange could relieve the clinical manifestations of TTP/HUS. Moreover, massive ascites appeared and worsened her condition. She died approximately one year after the diagnosis of polymyositis. The autopsy revealed centri-lobular hepatic necrosis and nonthrombotic obliteration of hepatic small veins. The diagnosis of hepatic veno-occlusive disease (VOD) was made. It was suspected that common factors other than cytoreductive therapy had damaged the endothelium and caused TTP/HUS and VOD in a case of polymyositis. (Internal Medicine 37: 694-699, 1998) |
| doi_str_mv | 10.2169/internalmedicine.37.694 |
| format | Article |
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During the therapy, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) occurred. Neither plasma infusion nor plasma exchange could relieve the clinical manifestations of TTP/HUS. Moreover, massive ascites appeared and worsened her condition. She died approximately one year after the diagnosis of polymyositis. The autopsy revealed centri-lobular hepatic necrosis and nonthrombotic obliteration of hepatic small veins. The diagnosis of hepatic veno-occlusive disease (VOD) was made. It was suspected that common factors other than cytoreductive therapy had damaged the endothelium and caused TTP/HUS and VOD in a case of polymyositis. 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Drug treatments ; Plasma Exchange ; Polymyositis - complications ; Polymyositis - drug therapy ; Prednisolone - adverse effects ; Purpura, Thrombotic Thrombocytopenic - complications ; Purpura, Thrombotic Thrombocytopenic - etiology ; Purpura, Thrombotic Thrombocytopenic - therapy ; Toxicity: blood</subject><ispartof>Internal Medicine, 1998, Vol.37(8), pp.694-699</ispartof><rights>The Japanese Society of Internal Medicine</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-e6a3dddb79ad191bf4cd6bcd77d8c846add2d9d35a71271aad8aed145ccb93633</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1601557$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9745858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ISHIDA, Yoh-ichi</creatorcontrib><creatorcontrib>UTIKOSHI, Manabu</creatorcontrib><creatorcontrib>KUROSAKI, Masao</creatorcontrib><creatorcontrib>OHTA, Katuroh</creatorcontrib><creatorcontrib>CHUJO, Tatsuya</creatorcontrib><creatorcontrib>AOYAMA, Shou</creatorcontrib><creatorcontrib>OHSAWA, Kenzo</creatorcontrib><creatorcontrib>SAITO, Katsuhiko</creatorcontrib><creatorcontrib>YOKOYAMA, Hitoshi</creatorcontrib><creatorcontrib>OHTA, Satoshi</creatorcontrib><title>Hepatic Veno-Occlusive Disease in a Case of Polymyositis Associated with Thrombotic Thrombocytopenic Purpura/hemolytic Uremic Syndrome</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 50-year-old woman was treated with prednisolone for polymyositis. During the therapy, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) occurred. Neither plasma infusion nor plasma exchange could relieve the clinical manifestations of TTP/HUS. Moreover, massive ascites appeared and worsened her condition. She died approximately one year after the diagnosis of polymyositis. The autopsy revealed centri-lobular hepatic necrosis and nonthrombotic obliteration of hepatic small veins. The diagnosis of hepatic veno-occlusive disease (VOD) was made. It was suspected that common factors other than cytoreductive therapy had damaged the endothelium and caused TTP/HUS and VOD in a case of polymyositis. (Internal Medicine 37: 694-699, 1998)</description><subject>Anti-Inflammatory Agents - adverse effects</subject><subject>ascites</subject><subject>autoimmune disease</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>endothelium</subject><subject>Female</subject><subject>Hemolytic-Uremic Syndrome - complications</subject><subject>Hemolytic-Uremic Syndrome - etiology</subject><subject>Hemolytic-Uremic Syndrome - therapy</subject><subject>Hepatic Veno-Occlusive Disease - complications</subject><subject>Hepatic Veno-Occlusive Disease - etiology</subject><subject>Hepatic Veno-Occlusive Disease - pathology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasma Exchange</subject><subject>Polymyositis - complications</subject><subject>Polymyositis - drug therapy</subject><subject>Prednisolone - adverse effects</subject><subject>Purpura, Thrombotic Thrombocytopenic - complications</subject><subject>Purpura, Thrombotic Thrombocytopenic - etiology</subject><subject>Purpura, Thrombotic Thrombocytopenic - therapy</subject><subject>Toxicity: blood</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUM1O3DAQthAIFtpHqOoD1yxxnMTxES0tICGxUqHXaGJPWKPEjuwsVV6gz42jXS0SXGZG8_3M6CPkJ0uXGSvllbEjegtdj9ooY3HJxbKU-RFZMJ7LRGS8OCaLVLIqyWI5I-chvKYpr4TMTsmpFHlRFdWC_L_DAUaj6F-0LnlUqtsG84b0xgSEgNRYCnQ1T66la9dN_eSCGU2g1yE4ZWBETf-ZcUOfNt71jZu99qOaRjegjYv11g9bD1cb7KPFTHn22Mf2Z7I6cvEbOWmhC_h93y_I8-9fT6u75OHx9n51_ZCoXJRjgiVwrXUjJGgmWdPmSpeN0kLoSlV5CVpnWmpegGCZYAC6AtQsL5RqJC85vyBi56u8C8FjWw_e9OCnmqX1HGz9OdiaizoGG5U_dsph20TsoNsnGfHLPQ5BQdd6sMqED_syZUUhIm29o72GEV7wgIOPqXT45TyTMptfqHYlfnKgqg34Gi1_B_okqQ8</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>ISHIDA, Yoh-ichi</creator><creator>UTIKOSHI, Manabu</creator><creator>KUROSAKI, Masao</creator><creator>OHTA, Katuroh</creator><creator>CHUJO, Tatsuya</creator><creator>AOYAMA, Shou</creator><creator>OHSAWA, Kenzo</creator><creator>SAITO, Katsuhiko</creator><creator>YOKOYAMA, Hitoshi</creator><creator>OHTA, Satoshi</creator><general>The Japanese Society of Internal Medicine</general><general>Japanese Society of Internal Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1998</creationdate><title>Hepatic Veno-Occlusive Disease in a Case of Polymyositis Associated with Thrombotic Thrombocytopenic Purpura/hemolytic Uremic Syndrome</title><author>ISHIDA, Yoh-ichi ; UTIKOSHI, Manabu ; KUROSAKI, Masao ; OHTA, Katuroh ; CHUJO, Tatsuya ; AOYAMA, Shou ; OHSAWA, Kenzo ; SAITO, Katsuhiko ; YOKOYAMA, Hitoshi ; OHTA, Satoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-e6a3dddb79ad191bf4cd6bcd77d8c846add2d9d35a71271aad8aed145ccb93633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anti-Inflammatory Agents - adverse effects</topic><topic>ascites</topic><topic>autoimmune disease</topic><topic>Biological and medical sciences</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>endothelium</topic><topic>Female</topic><topic>Hemolytic-Uremic Syndrome - complications</topic><topic>Hemolytic-Uremic Syndrome - etiology</topic><topic>Hemolytic-Uremic Syndrome - therapy</topic><topic>Hepatic Veno-Occlusive Disease - complications</topic><topic>Hepatic Veno-Occlusive Disease - etiology</topic><topic>Hepatic Veno-Occlusive Disease - pathology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Plasma Exchange</topic><topic>Polymyositis - complications</topic><topic>Polymyositis - drug therapy</topic><topic>Prednisolone - adverse effects</topic><topic>Purpura, Thrombotic Thrombocytopenic - complications</topic><topic>Purpura, Thrombotic Thrombocytopenic - etiology</topic><topic>Purpura, Thrombotic Thrombocytopenic - therapy</topic><topic>Toxicity: blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ISHIDA, Yoh-ichi</creatorcontrib><creatorcontrib>UTIKOSHI, Manabu</creatorcontrib><creatorcontrib>KUROSAKI, Masao</creatorcontrib><creatorcontrib>OHTA, Katuroh</creatorcontrib><creatorcontrib>CHUJO, Tatsuya</creatorcontrib><creatorcontrib>AOYAMA, Shou</creatorcontrib><creatorcontrib>OHSAWA, Kenzo</creatorcontrib><creatorcontrib>SAITO, Katsuhiko</creatorcontrib><creatorcontrib>YOKOYAMA, Hitoshi</creatorcontrib><creatorcontrib>OHTA, Satoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ISHIDA, Yoh-ichi</au><au>UTIKOSHI, Manabu</au><au>KUROSAKI, Masao</au><au>OHTA, Katuroh</au><au>CHUJO, Tatsuya</au><au>AOYAMA, Shou</au><au>OHSAWA, Kenzo</au><au>SAITO, Katsuhiko</au><au>YOKOYAMA, Hitoshi</au><au>OHTA, Satoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatic Veno-Occlusive Disease in a Case of Polymyositis Associated with Thrombotic Thrombocytopenic Purpura/hemolytic Uremic Syndrome</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>1998</date><risdate>1998</risdate><volume>37</volume><issue>8</issue><spage>694</spage><epage>699</epage><pages>694-699</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 50-year-old woman was treated with prednisolone for polymyositis. During the therapy, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) occurred. Neither plasma infusion nor plasma exchange could relieve the clinical manifestations of TTP/HUS. Moreover, massive ascites appeared and worsened her condition. She died approximately one year after the diagnosis of polymyositis. The autopsy revealed centri-lobular hepatic necrosis and nonthrombotic obliteration of hepatic small veins. The diagnosis of hepatic veno-occlusive disease (VOD) was made. It was suspected that common factors other than cytoreductive therapy had damaged the endothelium and caused TTP/HUS and VOD in a case of polymyositis. (Internal Medicine 37: 694-699, 1998)</abstract><cop>Tokyo</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>9745858</pmid><doi>10.2169/internalmedicine.37.694</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Internal Medicine, 1998, Vol.37(8), pp.694-699 |
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| recordid | cdi_crossref_primary_10_2169_internalmedicine_37_694 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Anti-Inflammatory Agents - adverse effects ascites autoimmune disease Biological and medical sciences Drug toxicity and drugs side effects treatment endothelium Female Hemolytic-Uremic Syndrome - complications Hemolytic-Uremic Syndrome - etiology Hemolytic-Uremic Syndrome - therapy Hepatic Veno-Occlusive Disease - complications Hepatic Veno-Occlusive Disease - etiology Hepatic Veno-Occlusive Disease - pathology Humans Medical sciences Middle Aged Pharmacology. Drug treatments Plasma Exchange Polymyositis - complications Polymyositis - drug therapy Prednisolone - adverse effects Purpura, Thrombotic Thrombocytopenic - complications Purpura, Thrombotic Thrombocytopenic - etiology Purpura, Thrombotic Thrombocytopenic - therapy Toxicity: blood |
| title | Hepatic Veno-Occlusive Disease in a Case of Polymyositis Associated with Thrombotic Thrombocytopenic Purpura/hemolytic Uremic Syndrome |
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