Neurologic Features of Chronic Minamata Disease (Organic Mercury Poisoning) Certified at Autopsy
To better understand the neurologic events related to chronic Minamata disease (organic mercury poisoning), we studied data from 77 patients with Minamata disease as certified at autopsies performed from 1976 to 1994 (mean age: 72.3 years). Major neurologic findings included: sensory impairment in 8...
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| Veröffentlicht in: | Internal Medicine 1995, Vol.34(8), pp.744-747 |
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| creator | UCHINO, Makoto OKAJIMA, Toru ETO, Komyo KUMAMOTO, Toshihide MISHIMA, Isao ANDO, Masayuki |
| description | To better understand the neurologic events related to chronic Minamata disease (organic mercury poisoning), we studied data from 77 patients with Minamata disease as certified at autopsies performed from 1976 to 1994 (mean age: 72.3 years). Major neurologic findings included: sensory impairment in 80.5% of the patients which was limited to the extremities in 42.9%. Impairment of lower extremity coordination was present in 35.8% of the patients, constriction of the visual fields in 28.8%, and retrocochlear hearing loss in 15.3%. There was no correlation between the degree of cerebellar incoordination and the methylmercury concentration in the cerebellum. Compared with the classic type of Minamata disease, the incidence of major neurologic findings was markedly decreased. In light of these findings, supplemental examinations including brain computed tomography (CT), magnetic resonance imaging (MRI), short latency somatosensory evoked potential (SSEP), or tremogram may be necessary to clinically diagnose Minamata disease, especially in atypical or mild cases. (Internal Medicine 34: 744-747, 1995) |
| doi_str_mv | 10.2169/internalmedicine.34.744 |
| format | Article |
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Major neurologic findings included: sensory impairment in 80.5% of the patients which was limited to the extremities in 42.9%. Impairment of lower extremity coordination was present in 35.8% of the patients, constriction of the visual fields in 28.8%, and retrocochlear hearing loss in 15.3%. There was no correlation between the degree of cerebellar incoordination and the methylmercury concentration in the cerebellum. Compared with the classic type of Minamata disease, the incidence of major neurologic findings was markedly decreased. In light of these findings, supplemental examinations including brain computed tomography (CT), magnetic resonance imaging (MRI), short latency somatosensory evoked potential (SSEP), or tremogram may be necessary to clinically diagnose Minamata disease, especially in atypical or mild cases. (Internal Medicine 34: 744-747, 1995)</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.34.744</identifier><identifier>PMID: 8563113</identifier><language>eng</language><publisher>Tokyo: The Japanese Society of Internal Medicine</publisher><subject>Adult ; Aged ; Aged, 80 and over ; autopsy ; Biological and medical sciences ; Cerebellar Ataxia - etiology ; Cerebellar Ataxia - pathology ; cerebellar incoordination ; Cerebellum - chemistry ; Cerebellum - pathology ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chronic Disease ; Female ; Hearing Loss, Sensorineural - etiology ; Hearing Loss, Sensorineural - pathology ; Humans ; Male ; Medical sciences ; Mercury Poisoning - complications ; Mercury Poisoning - pathology ; Metals and various inorganic compounds ; Methylmercury Compounds - analysis ; methylmercury concentration ; Middle Aged ; Minamata disease ; Retrospective Studies ; Toxicology ; Vision Disorders - etiology ; Vision Disorders - pathology ; visual constriction</subject><ispartof>Internal Medicine, 1995, Vol.34(8), pp.744-747</ispartof><rights>The Japanese Society of Internal Medicine</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-d7bd169e3c79754593f2b7bb9327b0715c99f7bcfa6474e3dad707e9879e2cba3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2892487$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8563113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>UCHINO, Makoto</creatorcontrib><creatorcontrib>OKAJIMA, Toru</creatorcontrib><creatorcontrib>ETO, Komyo</creatorcontrib><creatorcontrib>KUMAMOTO, Toshihide</creatorcontrib><creatorcontrib>MISHIMA, Isao</creatorcontrib><creatorcontrib>ANDO, Masayuki</creatorcontrib><title>Neurologic Features of Chronic Minamata Disease (Organic Mercury Poisoning) Certified at Autopsy</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>To better understand the neurologic events related to chronic Minamata disease (organic mercury poisoning), we studied data from 77 patients with Minamata disease as certified at autopsies performed from 1976 to 1994 (mean age: 72.3 years). Major neurologic findings included: sensory impairment in 80.5% of the patients which was limited to the extremities in 42.9%. Impairment of lower extremity coordination was present in 35.8% of the patients, constriction of the visual fields in 28.8%, and retrocochlear hearing loss in 15.3%. There was no correlation between the degree of cerebellar incoordination and the methylmercury concentration in the cerebellum. Compared with the classic type of Minamata disease, the incidence of major neurologic findings was markedly decreased. In light of these findings, supplemental examinations including brain computed tomography (CT), magnetic resonance imaging (MRI), short latency somatosensory evoked potential (SSEP), or tremogram may be necessary to clinically diagnose Minamata disease, especially in atypical or mild cases. (Internal Medicine 34: 744-747, 1995)</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>autopsy</subject><subject>Biological and medical sciences</subject><subject>Cerebellar Ataxia - etiology</subject><subject>Cerebellar Ataxia - pathology</subject><subject>cerebellar incoordination</subject><subject>Cerebellum - chemistry</subject><subject>Cerebellum - pathology</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Hearing Loss, Sensorineural - etiology</subject><subject>Hearing Loss, Sensorineural - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mercury Poisoning - complications</subject><subject>Mercury Poisoning - pathology</subject><subject>Metals and various inorganic compounds</subject><subject>Methylmercury Compounds - analysis</subject><subject>methylmercury concentration</subject><subject>Middle Aged</subject><subject>Minamata disease</subject><subject>Retrospective Studies</subject><subject>Toxicology</subject><subject>Vision Disorders - etiology</subject><subject>Vision Disorders - pathology</subject><subject>visual constriction</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkD9PwzAQxS0EKqXwERAeGGBIif-kjkdUKCAV2gHmcHEuras0qexk6LfHpVUHWM7S_d473z1Cblg85GykH2zdoquhWmNhja1xKORQSXlC-kxIHSkuklPSjzVLIx7KObnwfhXHIlWa90gvTUaCMdEn3x_YuaZqFtbQCULbOfS0Kel46Zo69N5tDWtogT5Zj-CR3s3cAn4JOtO5LZ031gdpvbinY3StLS0WFFr62LXNxm8vyVkJlcerwzsgX5Pnz_FrNJ29vI0fp5FJhGijQuVFuAuFUVolMtGi5LnKcy24ymPFEqN1qXJTwkgqiaKAQsUKdbgHuclBDIjazzWu8d5hmW2cXYPbZizOdpFlfyPLhMxCZMF5vXduujywo--QUeC3Bw7eQFU6qI31RxlPNZepCrL5XrbyLSzwyCFkYir89z3Tmu9WSPclbHKUmiW4DGvxA1qAmE4</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>UCHINO, Makoto</creator><creator>OKAJIMA, Toru</creator><creator>ETO, Komyo</creator><creator>KUMAMOTO, Toshihide</creator><creator>MISHIMA, Isao</creator><creator>ANDO, Masayuki</creator><general>The Japanese Society of Internal Medicine</general><general>Japanese Society of Internal Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1995</creationdate><title>Neurologic Features of Chronic Minamata Disease (Organic Mercury Poisoning) Certified at Autopsy</title><author>UCHINO, Makoto ; OKAJIMA, Toru ; ETO, Komyo ; KUMAMOTO, Toshihide ; MISHIMA, Isao ; ANDO, Masayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-d7bd169e3c79754593f2b7bb9327b0715c99f7bcfa6474e3dad707e9879e2cba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>autopsy</topic><topic>Biological and medical sciences</topic><topic>Cerebellar Ataxia - etiology</topic><topic>Cerebellar Ataxia - pathology</topic><topic>cerebellar incoordination</topic><topic>Cerebellum - chemistry</topic><topic>Cerebellum - pathology</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Hearing Loss, Sensorineural - etiology</topic><topic>Hearing Loss, Sensorineural - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mercury Poisoning - complications</topic><topic>Mercury Poisoning - pathology</topic><topic>Metals and various inorganic compounds</topic><topic>Methylmercury Compounds - analysis</topic><topic>methylmercury concentration</topic><topic>Middle Aged</topic><topic>Minamata disease</topic><topic>Retrospective Studies</topic><topic>Toxicology</topic><topic>Vision Disorders - etiology</topic><topic>Vision Disorders - pathology</topic><topic>visual constriction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>UCHINO, Makoto</creatorcontrib><creatorcontrib>OKAJIMA, Toru</creatorcontrib><creatorcontrib>ETO, Komyo</creatorcontrib><creatorcontrib>KUMAMOTO, Toshihide</creatorcontrib><creatorcontrib>MISHIMA, Isao</creatorcontrib><creatorcontrib>ANDO, Masayuki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>UCHINO, Makoto</au><au>OKAJIMA, Toru</au><au>ETO, Komyo</au><au>KUMAMOTO, Toshihide</au><au>MISHIMA, Isao</au><au>ANDO, Masayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurologic Features of Chronic Minamata Disease (Organic Mercury Poisoning) Certified at Autopsy</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>1995</date><risdate>1995</risdate><volume>34</volume><issue>8</issue><spage>744</spage><epage>747</epage><pages>744-747</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>To better understand the neurologic events related to chronic Minamata disease (organic mercury poisoning), we studied data from 77 patients with Minamata disease as certified at autopsies performed from 1976 to 1994 (mean age: 72.3 years). Major neurologic findings included: sensory impairment in 80.5% of the patients which was limited to the extremities in 42.9%. Impairment of lower extremity coordination was present in 35.8% of the patients, constriction of the visual fields in 28.8%, and retrocochlear hearing loss in 15.3%. There was no correlation between the degree of cerebellar incoordination and the methylmercury concentration in the cerebellum. Compared with the classic type of Minamata disease, the incidence of major neurologic findings was markedly decreased. In light of these findings, supplemental examinations including brain computed tomography (CT), magnetic resonance imaging (MRI), short latency somatosensory evoked potential (SSEP), or tremogram may be necessary to clinically diagnose Minamata disease, especially in atypical or mild cases. (Internal Medicine 34: 744-747, 1995)</abstract><cop>Tokyo</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>8563113</pmid><doi>10.2169/internalmedicine.34.744</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over autopsy Biological and medical sciences Cerebellar Ataxia - etiology Cerebellar Ataxia - pathology cerebellar incoordination Cerebellum - chemistry Cerebellum - pathology Chemical and industrial products toxicology. Toxic occupational diseases Chronic Disease Female Hearing Loss, Sensorineural - etiology Hearing Loss, Sensorineural - pathology Humans Male Medical sciences Mercury Poisoning - complications Mercury Poisoning - pathology Metals and various inorganic compounds Methylmercury Compounds - analysis methylmercury concentration Middle Aged Minamata disease Retrospective Studies Toxicology Vision Disorders - etiology Vision Disorders - pathology visual constriction |
| title | Neurologic Features of Chronic Minamata Disease (Organic Mercury Poisoning) Certified at Autopsy |
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