Atherosclerosis and Thrombosis -with special reference to the role of thrombi in the development of atherosclerosis

Various hypotheses have been advanced concerning the pathogenesis of atherosclerosis especially as regards the initiating event. Two opposing theories are prevalent today, each supported by considerable evidence. The proponents of one theory hold that arterial plaque formation is initiated by deposition of lip id beneath the endothelial lining cells. The proponents of the opposing other theory hold that the plaque formation is initiated by the deposition of fibrin on the endothelial surface, which is incorporated into the intima. This report is concerned with the role of thrombosis or fibrin deposits in the pathogenesis of atherosclerosis.