Steady-state kinetics of the quinolone derivatives ofloxacin, enoxacin, ciprofloxacin and pefloxacin during maintenance treatment with theophylline

Some of the new quinolone derivatives may be of value in the treatment of respiratory tract infections. It has been demonstrated that enoxacin, pefloxacin and ciprofloxacin, but not ofloxacin, decreased the metabolic clearance of the bronchodilator theophylline. This resulted in elevated plasma theo...

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Veröffentlicht in:	Drugs (New York, N.Y.) N.Y.), 1987, Vol.34 Suppl 1 (Supplement 1), p.159-169
Hauptverfasser:	Wijnands, W J, Vree, T B, Baars, A M, van Herwaarden, C L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Infective Agents - pharmacokinetics Ciprofloxacin - pharmacokinetics Drug Interactions Enoxacin Female Humans Male Middle Aged Naphthyridines - pharmacokinetics Norfloxacin - analogs & derivatives Norfloxacin - pharmacokinetics Ofloxacin Oxazines - pharmacokinetics Pefloxacin Quinolines - pharmacokinetics Theophylline - adverse effects
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