Clinical pharmacokinetics of intranasal sumatriptan

A substantial proportion of migraine patients have gastric stasis and suffer severe nausea and/or vomiting during their migraine attack. This may lead to erratic absorption from the gastrointestinal tract and make oral treatment unsatisfactory. For such patients, an intranasal formulation may be adv...

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Veröffentlicht in:	Clinical pharmacokinetics 2002, Vol.41 (11), p.801-811
Hauptverfasser:	Fuseau, Eliane, Petricoul, Olivier, Moore, Katy H P, Barrow, Andrew, Ibbotson, Tim
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Adolescent Adult Animals Child Clinical Trials as Topic Dose-Response Relationship, Drug Drug Interactions Humans Kidney Diseases - complications Kidney Diseases - metabolism Liver Diseases - complications Liver Diseases - metabolism Migraine Disorders - complications Migraine Disorders - drug therapy Migraine Disorders - metabolism Serotonin Receptor Agonists - administration & dosage Serotonin Receptor Agonists - adverse effects Serotonin Receptor Agonists - pharmacokinetics Sumatriptan - administration & dosage Sumatriptan - adverse effects Sumatriptan - pharmacokinetics
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