Metabolism and pharmacokinetics of oxazaphosphorines

The 2 most commonly used oxazaphosphorines are cyclophosphamide and ifosfamide, although other bifunctional mustard analogues continue to be investigated. The pharmacology of these agents is determined by their metabolism, since the parent drug is relatively inactive. For cyclophosphamide, eliminati...

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Veröffentlicht in:	Clinical pharmacokinetics 2000-04, Vol.38 (4), p.291-304
Hauptverfasser:	Boddy, A V, Yule, S M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Alkylating - metabolism Antineoplastic Agents, Alkylating - pharmacokinetics Antineoplastic Agents, Alkylating - therapeutic use Cyclophosphamide - metabolism Cyclophosphamide - pharmacokinetics Cyclophosphamide - therapeutic use Drug Interactions Humans Ifosfamide - metabolism Ifosfamide - pharmacokinetics Ifosfamide - therapeutic use
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