Assessment of the pharmacokinetic interaction between zileuton and digoxin in humans

The effects of coadministration of zileuton on the pharmacokinetic profile of digoxin were investigated in a double-blind placebo-controlled crossover study in 12 healthy male volunteers. During each study phase, the subjects received zileuton 600mg every 6 hours (regimen A) or placebo (regimen B) f...

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Veröffentlicht in:	Clinical pharmacokinetics 1995, Vol.29 Suppl 2 (Supplement 2), p.92-97
Hauptverfasser:	Awni, W M, Hussein, Z, Cavanaugh, J H, Granneman, G R, Dubé, L M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Analysis of Variance Blood Cell Count - drug effects Cardiotonic Agents - administration & dosage Cardiotonic Agents - blood Cardiotonic Agents - pharmacokinetics Cross-Over Studies Digoxin - administration & dosage Digoxin - blood Digoxin - pharmacokinetics Digoxin - pharmacology Double-Blind Method Drug Interactions Electrocardiography - drug effects Half-Life Humans Hydroxyurea - administration & dosage Hydroxyurea - analogs & derivatives Hydroxyurea - blood Hydroxyurea - pharmacology Isotope Labeling Lipoxygenase Inhibitors - administration & dosage Lipoxygenase Inhibitors - blood Lipoxygenase Inhibitors - pharmacology Male Radioimmunoassay
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