Taste receptor gene expression is associated with decreased eGFR in patients with diabetes
Dysgeusia is not only associated with zinc deficiency but also with certain drugs or diseases, including diabetes and renal failure. It often lowers the patient’s quality of life and hinders access to proper nutrition. The underlying mechanism is unclear and there is a lack of awareness among patien...
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| Veröffentlicht in: | The Journal of Medical Investigation 2022, Vol.69(1.2), pp.120-126 |
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| container_issue | 1.2 |
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| container_title | The Journal of Medical Investigation |
| container_volume | 69 |
| creator | Beppu, Kana Kawakami, Ayuka Mishima, Yuna Tsutsumi, Rie Kuroda, Masashi Mori, Hiroyasu Kuroda, Akio Matsuhisa, Munehisa Sakaue, Hiroshi |
| description | Dysgeusia is not only associated with zinc deficiency but also with certain drugs or diseases, including diabetes and renal failure. It often lowers the patient’s quality of life and hinders access to proper nutrition. The underlying mechanism is unclear and there is a lack of awareness among patients. Here, we focused on lingual taste receptor gene expression in diabetes and elucidated the relationship between taste receptor gene expression and renal function. Forty-seven patients with diabetes and 10 healthy subjects (control group) were enrolled. Lingual foliate papillae were scraped and the derived cDNA was quantified by real-time polymerase chain reaction. Dysgeusia was assessed using SALSAVE?. All statistical analyses were performed using JMP? software 13. The expression of T1R1 and T1R2 was significantly upregulated in type 2 diabetes patients as compared with that in healthy subjects (P |
| doi_str_mv | 10.2152/jmi.69.120 |
| format | Article |
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It often lowers the patient’s quality of life and hinders access to proper nutrition. The underlying mechanism is unclear and there is a lack of awareness among patients. Here, we focused on lingual taste receptor gene expression in diabetes and elucidated the relationship between taste receptor gene expression and renal function. Forty-seven patients with diabetes and 10 healthy subjects (control group) were enrolled. Lingual foliate papillae were scraped and the derived cDNA was quantified by real-time polymerase chain reaction. Dysgeusia was assessed using SALSAVE?. All statistical analyses were performed using JMP? software 13. The expression of T1R1 and T1R2 was significantly upregulated in type 2 diabetes patients as compared with that in healthy subjects (P<0.01) but did not change in type 1 diabetes patients. T1R3 expression positively correlated and Scnn1 expression negatively correlated with estimated glomerular filtration rate, suggesting that altered taste receptor gene expression could reflect impaired renal function. Thus, alterations in T1R3 and Scnn1 expression in diabetes correlated with renal function. Taste receptor gene expression dysregulation could indicate dysgeusia associated with impaired renal function in patients with diabetes. J. Med. Invest. 69 : 120-126, February, 2022</description><identifier>ISSN: 1343-1420</identifier><identifier>EISSN: 1349-6867</identifier><identifier>DOI: 10.2152/jmi.69.120</identifier><identifier>PMID: 35466133</identifier><language>eng</language><publisher>Japan: The University of Tokushima Faculty of Medicine</publisher><subject>Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - genetics ; Dysgeusia ; Dysgeusia - genetics ; eGFR ; Gene Expression ; Humans ; Quality of Life ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - metabolism ; Taste - genetics ; Taste receptor gene</subject><ispartof>The Journal of Medical Investigation, 2022, Vol.69(1.2), pp.120-126</ispartof><rights>2022 by The University of Tokushima Faculty of Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-f29b64e5095bedada3dab3bda0ce925f0db1f0947f963405e07d8afa3c267ba33</citedby><cites>FETCH-LOGICAL-c469t-f29b64e5095bedada3dab3bda0ce925f0db1f0947f963405e07d8afa3c267ba33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35466133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beppu, Kana</creatorcontrib><creatorcontrib>Kawakami, Ayuka</creatorcontrib><creatorcontrib>Mishima, Yuna</creatorcontrib><creatorcontrib>Tsutsumi, Rie</creatorcontrib><creatorcontrib>Kuroda, Masashi</creatorcontrib><creatorcontrib>Mori, Hiroyasu</creatorcontrib><creatorcontrib>Kuroda, Akio</creatorcontrib><creatorcontrib>Matsuhisa, Munehisa</creatorcontrib><creatorcontrib>Sakaue, Hiroshi</creatorcontrib><title>Taste receptor gene expression is associated with decreased eGFR in patients with diabetes</title><title>The Journal of Medical Investigation</title><addtitle>J. Med. Invest.</addtitle><description>Dysgeusia is not only associated with zinc deficiency but also with certain drugs or diseases, including diabetes and renal failure. It often lowers the patient’s quality of life and hinders access to proper nutrition. The underlying mechanism is unclear and there is a lack of awareness among patients. Here, we focused on lingual taste receptor gene expression in diabetes and elucidated the relationship between taste receptor gene expression and renal function. Forty-seven patients with diabetes and 10 healthy subjects (control group) were enrolled. Lingual foliate papillae were scraped and the derived cDNA was quantified by real-time polymerase chain reaction. Dysgeusia was assessed using SALSAVE?. All statistical analyses were performed using JMP? software 13. The expression of T1R1 and T1R2 was significantly upregulated in type 2 diabetes patients as compared with that in healthy subjects (P<0.01) but did not change in type 1 diabetes patients. T1R3 expression positively correlated and Scnn1 expression negatively correlated with estimated glomerular filtration rate, suggesting that altered taste receptor gene expression could reflect impaired renal function. Thus, alterations in T1R3 and Scnn1 expression in diabetes correlated with renal function. Taste receptor gene expression dysregulation could indicate dysgeusia associated with impaired renal function in patients with diabetes. J. Med. Invest. 69 : 120-126, February, 2022</description><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Dysgeusia</subject><subject>Dysgeusia - genetics</subject><subject>eGFR</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Quality of Life</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Taste - genetics</subject><subject>Taste receptor gene</subject><issn>1343-1420</issn><issn>1349-6867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFKAzEURYMotlY3foBkLUzNJJNMsxIptgoFQerGzfCSvGlT2pkhiah_72hrV-8-7uEuDiHXORvzXPK7zc6PlR7nnJ2QYS4KnamJKk__ssjygrMBuYhxw5gQUspzMhCyUCoXYkjelxAT0oAWu9QGusIGKX51AWP0bUN9pBBjaz0kdPTTpzV1aANC7F-cz16pb2gHyWOT4qH3YDBhvCRnNWwjXh3uiLzNHpfTp2zxMn-ePiwyWyidspprowqUTEuDDhwIB0YYB8yi5rJmzuQ100VZayUKJpGVbgI1CMtVaUCIEbnd79rQxhiwrrrgdxC-q5xVv4KqXlCldNUL6uGbPdx9mB26I_pvpAfu98AmJljhEYCQvN3icavih8ljY9cQKmzEDxOZeg4</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Beppu, Kana</creator><creator>Kawakami, Ayuka</creator><creator>Mishima, Yuna</creator><creator>Tsutsumi, Rie</creator><creator>Kuroda, Masashi</creator><creator>Mori, Hiroyasu</creator><creator>Kuroda, Akio</creator><creator>Matsuhisa, Munehisa</creator><creator>Sakaue, Hiroshi</creator><general>The University of Tokushima Faculty of Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2022</creationdate><title>Taste receptor gene expression is associated with decreased eGFR in patients with diabetes</title><author>Beppu, Kana ; Kawakami, Ayuka ; Mishima, Yuna ; Tsutsumi, Rie ; Kuroda, Masashi ; Mori, Hiroyasu ; Kuroda, Akio ; Matsuhisa, Munehisa ; Sakaue, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-f29b64e5095bedada3dab3bda0ce925f0db1f0947f963405e07d8afa3c267ba33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Dysgeusia</topic><topic>Dysgeusia - genetics</topic><topic>eGFR</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Quality of Life</topic><topic>Receptors, G-Protein-Coupled - genetics</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Taste - genetics</topic><topic>Taste receptor gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beppu, Kana</creatorcontrib><creatorcontrib>Kawakami, Ayuka</creatorcontrib><creatorcontrib>Mishima, Yuna</creatorcontrib><creatorcontrib>Tsutsumi, Rie</creatorcontrib><creatorcontrib>Kuroda, Masashi</creatorcontrib><creatorcontrib>Mori, Hiroyasu</creatorcontrib><creatorcontrib>Kuroda, Akio</creatorcontrib><creatorcontrib>Matsuhisa, Munehisa</creatorcontrib><creatorcontrib>Sakaue, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Journal of Medical Investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beppu, Kana</au><au>Kawakami, Ayuka</au><au>Mishima, Yuna</au><au>Tsutsumi, Rie</au><au>Kuroda, Masashi</au><au>Mori, Hiroyasu</au><au>Kuroda, Akio</au><au>Matsuhisa, Munehisa</au><au>Sakaue, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Taste receptor gene expression is associated with decreased eGFR in patients with diabetes</atitle><jtitle>The Journal of Medical Investigation</jtitle><addtitle>J. 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The expression of T1R1 and T1R2 was significantly upregulated in type 2 diabetes patients as compared with that in healthy subjects (P<0.01) but did not change in type 1 diabetes patients. T1R3 expression positively correlated and Scnn1 expression negatively correlated with estimated glomerular filtration rate, suggesting that altered taste receptor gene expression could reflect impaired renal function. Thus, alterations in T1R3 and Scnn1 expression in diabetes correlated with renal function. Taste receptor gene expression dysregulation could indicate dysgeusia associated with impaired renal function in patients with diabetes. J. Med. Invest. 69 : 120-126, February, 2022</abstract><cop>Japan</cop><pub>The University of Tokushima Faculty of Medicine</pub><pmid>35466133</pmid><doi>10.2152/jmi.69.120</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals |
| subjects | Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Dysgeusia Dysgeusia - genetics eGFR Gene Expression Humans Quality of Life Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Taste - genetics Taste receptor gene |
| title | Taste receptor gene expression is associated with decreased eGFR in patients with diabetes |
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