The prevalence and clinical features of asthma-COPD overlap (ACO) definitively diagnosed according to the Japanese Respiratory Society Guidelines for the Management of ACO 2018
Background Asthma-COPD overlap (ACO) is a disease that shares clinical features of both asthma and COPD. The purpose of this study is to investigate the prevalence and clinical features of ACO. Methods We retrospectively reviewed data for 170 patients with persistent airflow limitation and diagnosed...
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| Veröffentlicht in: | The Journal of Medical Investigation 2019/02/15, Vol.66(1.2), pp.157-164 |
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| creator | Yamamura, Kenta Hara, Johsuke Kobayashi, Takafumi Ohkura, Noriyuki Abo, Miki Akasaki, Kyota Nomura, Syunichi Yuasa, Mizuki Saeki, Keigo Terada, Nanao Matsuoka, Hiroki Tambo, Yuichi Nishikawa, Shingo Sone, Takashi Kimura, Hideharu Kasahara, Kazuo |
| description | Background Asthma-COPD overlap (ACO) is a disease that shares clinical features of both asthma and COPD. The purpose of this study is to investigate the prevalence and clinical features of ACO. Methods We retrospectively reviewed data for 170 patients with persistent airflow limitation and diagnosed them according to “The Japanese Respiratory Society Guidelines for the Management of ACO 2018”. Results Of the 170 patients, 111 were diagnosed as follows : COPD (74 patients, 66.6%), ACO (34 patients, 30.6%), and asthma (3 patients, 2.8%). There was no significant difference in clinical features between ACO and COPD patients. The following pulmonary function tests were significantly lower in ACO than in COPD patients : forced expiratory volume in 1 second/forced vital capacity, peak expiratory flow, maximal mid-expiratory flow, and the maximum expiratory flow at 50%and75%. The following respiratory impedance parameters were significantly higher in ACO than in COPD patients : respiratory resistance (Rrs) at 5 Hz (R5), Rrsat 20 Hz (R20), R5-R20, and low-frequency reactance area. Conclusions About 30% of patients with persistent airflow limitation were diagnosed with ACO. ACO patients had lower lung function and higher respiratory impedance compared with COPD patients. J. Med. Invest. 66 : 157-164, February, 2019 |
| doi_str_mv | 10.2152/jmi.66.157 |
| format | Article |
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The purpose of this study is to investigate the prevalence and clinical features of ACO. Methods We retrospectively reviewed data for 170 patients with persistent airflow limitation and diagnosed them according to “The Japanese Respiratory Society Guidelines for the Management of ACO 2018”. Results Of the 170 patients, 111 were diagnosed as follows : COPD (74 patients, 66.6%), ACO (34 patients, 30.6%), and asthma (3 patients, 2.8%). There was no significant difference in clinical features between ACO and COPD patients. The following pulmonary function tests were significantly lower in ACO than in COPD patients : forced expiratory volume in 1 second/forced vital capacity, peak expiratory flow, maximal mid-expiratory flow, and the maximum expiratory flow at 50%and75%. The following respiratory impedance parameters were significantly higher in ACO than in COPD patients : respiratory resistance (Rrs) at 5 Hz (R5), Rrsat 20 Hz (R20), R5-R20, and low-frequency reactance area. Conclusions About 30% of patients with persistent airflow limitation were diagnosed with ACO. ACO patients had lower lung function and higher respiratory impedance compared with COPD patients. J. Med. Invest. 66 : 157-164, February, 2019</description><identifier>ISSN: 1343-1420</identifier><identifier>EISSN: 1349-6867</identifier><identifier>DOI: 10.2152/jmi.66.157</identifier><identifier>PMID: 31064931</identifier><language>eng</language><publisher>Japan: The University of Tokushima Faculty of Medicine</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Asthma - diagnosis ; Asthma - epidemiology ; Asthma-COPD overlap (ACO) ; bronchial asthma (BA) ; chronic obstructive pulmonary disease (COPD) ; Female ; Humans ; Japan - epidemiology ; Male ; Middle Aged ; Practice Guidelines as Topic ; Prevalence ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - epidemiology ; pulmonary function ; Retrospective Studies</subject><ispartof>The Journal of Medical Investigation, 2019/02/15, Vol.66(1.2), pp.157-164</ispartof><rights>2019 by The University of Tokushima Faculty of Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-b4645bd22e11353d8216457a7f333c0fa053b133e49ca7590c04da38308a27923</citedby><cites>FETCH-LOGICAL-c570t-b4645bd22e11353d8216457a7f333c0fa053b133e49ca7590c04da38308a27923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31064931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamura, Kenta</creatorcontrib><creatorcontrib>Hara, Johsuke</creatorcontrib><creatorcontrib>Kobayashi, Takafumi</creatorcontrib><creatorcontrib>Ohkura, Noriyuki</creatorcontrib><creatorcontrib>Abo, Miki</creatorcontrib><creatorcontrib>Akasaki, Kyota</creatorcontrib><creatorcontrib>Nomura, Syunichi</creatorcontrib><creatorcontrib>Yuasa, Mizuki</creatorcontrib><creatorcontrib>Saeki, Keigo</creatorcontrib><creatorcontrib>Terada, Nanao</creatorcontrib><creatorcontrib>Matsuoka, Hiroki</creatorcontrib><creatorcontrib>Tambo, Yuichi</creatorcontrib><creatorcontrib>Nishikawa, Shingo</creatorcontrib><creatorcontrib>Sone, Takashi</creatorcontrib><creatorcontrib>Kimura, Hideharu</creatorcontrib><creatorcontrib>Kasahara, Kazuo</creatorcontrib><title>The prevalence and clinical features of asthma-COPD overlap (ACO) definitively diagnosed according to the Japanese Respiratory Society Guidelines for the Management of ACO 2018</title><title>The Journal of Medical Investigation</title><addtitle>J. Med. Invest.</addtitle><description>Background Asthma-COPD overlap (ACO) is a disease that shares clinical features of both asthma and COPD. The purpose of this study is to investigate the prevalence and clinical features of ACO. Methods We retrospectively reviewed data for 170 patients with persistent airflow limitation and diagnosed them according to “The Japanese Respiratory Society Guidelines for the Management of ACO 2018”. Results Of the 170 patients, 111 were diagnosed as follows : COPD (74 patients, 66.6%), ACO (34 patients, 30.6%), and asthma (3 patients, 2.8%). There was no significant difference in clinical features between ACO and COPD patients. The following pulmonary function tests were significantly lower in ACO than in COPD patients : forced expiratory volume in 1 second/forced vital capacity, peak expiratory flow, maximal mid-expiratory flow, and the maximum expiratory flow at 50%and75%. The following respiratory impedance parameters were significantly higher in ACO than in COPD patients : respiratory resistance (Rrs) at 5 Hz (R5), Rrsat 20 Hz (R20), R5-R20, and low-frequency reactance area. Conclusions About 30% of patients with persistent airflow limitation were diagnosed with ACO. ACO patients had lower lung function and higher respiratory impedance compared with COPD patients. J. Med. Invest. 66 : 157-164, February, 2019</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asthma - diagnosis</subject><subject>Asthma - epidemiology</subject><subject>Asthma-COPD overlap (ACO)</subject><subject>bronchial asthma (BA)</subject><subject>chronic obstructive pulmonary disease (COPD)</subject><subject>Female</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Practice Guidelines as Topic</subject><subject>Prevalence</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnosis</subject><subject>Pulmonary Disease, Chronic Obstructive - epidemiology</subject><subject>pulmonary function</subject><subject>Retrospective Studies</subject><issn>1343-1420</issn><issn>1349-6867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kN1uEzEQRlcIREvhhgdAvgSkDbZnvT9XqApQQEVBUK5XE3s2cbRrr2wnUt6KR8RtSq7GGh99R_MVxWvBF1Io-WE32UVdL4RqnhSXAqqurNu6efrwhlJUkl8UL2LccQ6glHpeXIDgddWBuCz-3m2JzYEOOJLTxNAZpkfrrMaRDYRpHygyPzCMaTthuVz9_MT8gcKIM3t7vVy9Y4aGzCd7oPHIjMWN85EMQ619MNZtWPIsZct3nNFRJPaL4mwDJh-O7LfXltKR3eytoezNssGHB_4HOtzQRC7d-7OKSS7al8WzAcdIrx7nVfHny-e75dfydnXzbXl9W2rV8FSuq7pSayMlCQEKTCtFXjTYDACg-YBcwVoAUNVpbFTHNa8MQgu8Rdl0Eq6K96dcHXyMgYZ-DnbCcOwF7-9r73PtfV33ufYMvznB8349kTmj_3vOwMcTsIspH3UGMCSrRzpn9fIx8vyjtxh6cvAPtpCVXg</recordid><startdate>20190215</startdate><enddate>20190215</enddate><creator>Yamamura, Kenta</creator><creator>Hara, Johsuke</creator><creator>Kobayashi, Takafumi</creator><creator>Ohkura, Noriyuki</creator><creator>Abo, Miki</creator><creator>Akasaki, Kyota</creator><creator>Nomura, Syunichi</creator><creator>Yuasa, Mizuki</creator><creator>Saeki, Keigo</creator><creator>Terada, Nanao</creator><creator>Matsuoka, Hiroki</creator><creator>Tambo, Yuichi</creator><creator>Nishikawa, Shingo</creator><creator>Sone, Takashi</creator><creator>Kimura, Hideharu</creator><creator>Kasahara, Kazuo</creator><general>The University of Tokushima Faculty of Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20190215</creationdate><title>The prevalence and clinical features of asthma-COPD overlap (ACO) definitively diagnosed according to the Japanese Respiratory Society Guidelines for the Management of ACO 2018</title><author>Yamamura, Kenta ; Hara, Johsuke ; Kobayashi, Takafumi ; Ohkura, Noriyuki ; Abo, Miki ; Akasaki, Kyota ; Nomura, Syunichi ; Yuasa, Mizuki ; Saeki, Keigo ; Terada, Nanao ; Matsuoka, Hiroki ; Tambo, Yuichi ; Nishikawa, Shingo ; Sone, Takashi ; Kimura, Hideharu ; Kasahara, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-b4645bd22e11353d8216457a7f333c0fa053b133e49ca7590c04da38308a27923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asthma - diagnosis</topic><topic>Asthma - epidemiology</topic><topic>Asthma-COPD overlap (ACO)</topic><topic>bronchial asthma (BA)</topic><topic>chronic obstructive pulmonary disease (COPD)</topic><topic>Female</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Practice Guidelines as Topic</topic><topic>Prevalence</topic><topic>Pulmonary Disease, Chronic Obstructive - diagnosis</topic><topic>Pulmonary Disease, Chronic Obstructive - epidemiology</topic><topic>pulmonary function</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamura, Kenta</creatorcontrib><creatorcontrib>Hara, Johsuke</creatorcontrib><creatorcontrib>Kobayashi, Takafumi</creatorcontrib><creatorcontrib>Ohkura, Noriyuki</creatorcontrib><creatorcontrib>Abo, Miki</creatorcontrib><creatorcontrib>Akasaki, Kyota</creatorcontrib><creatorcontrib>Nomura, Syunichi</creatorcontrib><creatorcontrib>Yuasa, Mizuki</creatorcontrib><creatorcontrib>Saeki, Keigo</creatorcontrib><creatorcontrib>Terada, Nanao</creatorcontrib><creatorcontrib>Matsuoka, Hiroki</creatorcontrib><creatorcontrib>Tambo, Yuichi</creatorcontrib><creatorcontrib>Nishikawa, Shingo</creatorcontrib><creatorcontrib>Sone, Takashi</creatorcontrib><creatorcontrib>Kimura, Hideharu</creatorcontrib><creatorcontrib>Kasahara, Kazuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Journal of Medical Investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamura, Kenta</au><au>Hara, Johsuke</au><au>Kobayashi, Takafumi</au><au>Ohkura, Noriyuki</au><au>Abo, Miki</au><au>Akasaki, Kyota</au><au>Nomura, Syunichi</au><au>Yuasa, Mizuki</au><au>Saeki, Keigo</au><au>Terada, Nanao</au><au>Matsuoka, Hiroki</au><au>Tambo, Yuichi</au><au>Nishikawa, Shingo</au><au>Sone, Takashi</au><au>Kimura, Hideharu</au><au>Kasahara, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prevalence and clinical features of asthma-COPD overlap (ACO) definitively diagnosed according to the Japanese Respiratory Society Guidelines for the Management of ACO 2018</atitle><jtitle>The Journal of Medical Investigation</jtitle><addtitle>J. Med. Invest.</addtitle><date>2019-02-15</date><risdate>2019</risdate><volume>66</volume><issue>1.2</issue><spage>157</spage><epage>164</epage><pages>157-164</pages><issn>1343-1420</issn><eissn>1349-6867</eissn><abstract>Background Asthma-COPD overlap (ACO) is a disease that shares clinical features of both asthma and COPD. The purpose of this study is to investigate the prevalence and clinical features of ACO. Methods We retrospectively reviewed data for 170 patients with persistent airflow limitation and diagnosed them according to “The Japanese Respiratory Society Guidelines for the Management of ACO 2018”. Results Of the 170 patients, 111 were diagnosed as follows : COPD (74 patients, 66.6%), ACO (34 patients, 30.6%), and asthma (3 patients, 2.8%). There was no significant difference in clinical features between ACO and COPD patients. The following pulmonary function tests were significantly lower in ACO than in COPD patients : forced expiratory volume in 1 second/forced vital capacity, peak expiratory flow, maximal mid-expiratory flow, and the maximum expiratory flow at 50%and75%. The following respiratory impedance parameters were significantly higher in ACO than in COPD patients : respiratory resistance (Rrs) at 5 Hz (R5), Rrsat 20 Hz (R20), R5-R20, and low-frequency reactance area. Conclusions About 30% of patients with persistent airflow limitation were diagnosed with ACO. ACO patients had lower lung function and higher respiratory impedance compared with COPD patients. J. Med. Invest. 66 : 157-164, February, 2019</abstract><cop>Japan</cop><pub>The University of Tokushima Faculty of Medicine</pub><pmid>31064931</pmid><doi>10.2152/jmi.66.157</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Asthma - diagnosis Asthma - epidemiology Asthma-COPD overlap (ACO) bronchial asthma (BA) chronic obstructive pulmonary disease (COPD) Female Humans Japan - epidemiology Male Middle Aged Practice Guidelines as Topic Prevalence Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - epidemiology pulmonary function Retrospective Studies |
| title | The prevalence and clinical features of asthma-COPD overlap (ACO) definitively diagnosed according to the Japanese Respiratory Society Guidelines for the Management of ACO 2018 |
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