Insulin resistance as early sign of hepatic dysfunction in liver cirrhosis
Glucose intolerance characterized by postprandial hyperglycemia and hyperinsulinemia is commonly seen in patients with liver cirrhosis (LC). The aim of this study is to clarify the relation between glucose intolerance and disorder of liver function in patients with LC. The 75 g oral glucose toleranc...
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| Veröffentlicht in: | The Journal of Medical Investigation 2014, Vol.61(1.2), pp.180-189 |
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| container_title | The Journal of Medical Investigation |
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| creator | Taguchi, Kayo Yamanaka-Okumura, Hisami Mizuno, Akira Nakamura, Taki Shimada, Mitsuo Doi, Toshio Takeda, Eiji |
| description | Glucose intolerance characterized by postprandial hyperglycemia and hyperinsulinemia is commonly seen in patients with liver cirrhosis (LC). The aim of this study is to clarify the relation between glucose intolerance and disorder of liver function in patients with LC. The 75 g oral glucose tolerance test (75 g OGTT) and the hyperinsulinemic euglycemic clamp combined with 0.2 g/kg oral glucose load (HECGL) were conducted in 61 patients with LC. Based on the results of 75 g OGTT, the 61 patients with LC were divided into groups, 21 (34.4%) patients with normal glucose tolerance (LC-NGT), 12 (19.7%) patients with impaired glucose tolerance (LC-IGT) and 28 (45.9%) patients with diabetes mellitus (LC-DM). Fasting plasma glucose (FPG) level was normal in 50 (82.0%) patients with LC. All patients with LC showed insulin resistance in both peripheral (skeletal and adipose) and hepatic tissues evaluated by HECGL, although significant correlation between the degree of glucose intolerance and the severity of hepatic dysfunction was not observed. Insulin resistance in both liver and peripheral tissues is the early sign in the patients with LC. This fact indicates that nutritional care from early stages of LC would be necessary in the patients. J. Med. Invest. 61: 180-189, February, 2014 |
| doi_str_mv | 10.2152/jmi.61.180 |
| format | Article |
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The aim of this study is to clarify the relation between glucose intolerance and disorder of liver function in patients with LC. The 75 g oral glucose tolerance test (75 g OGTT) and the hyperinsulinemic euglycemic clamp combined with 0.2 g/kg oral glucose load (HECGL) were conducted in 61 patients with LC. Based on the results of 75 g OGTT, the 61 patients with LC were divided into groups, 21 (34.4%) patients with normal glucose tolerance (LC-NGT), 12 (19.7%) patients with impaired glucose tolerance (LC-IGT) and 28 (45.9%) patients with diabetes mellitus (LC-DM). Fasting plasma glucose (FPG) level was normal in 50 (82.0%) patients with LC. All patients with LC showed insulin resistance in both peripheral (skeletal and adipose) and hepatic tissues evaluated by HECGL, although significant correlation between the degree of glucose intolerance and the severity of hepatic dysfunction was not observed. Insulin resistance in both liver and peripheral tissues is the early sign in the patients with LC. This fact indicates that nutritional care from early stages of LC would be necessary in the patients. J. Med. Invest. 61: 180-189, February, 2014</description><identifier>ISSN: 1343-1420</identifier><identifier>EISSN: 1349-6867</identifier><identifier>DOI: 10.2152/jmi.61.180</identifier><identifier>PMID: 24705764</identifier><language>eng</language><publisher>Japan: The University of Tokushima Faculty of Medicine</publisher><subject>Aged ; Blood Glucose - metabolism ; Case-Control Studies ; diabetes mellitus ; Diabetes Mellitus - metabolism ; Diabetes Mellitus - physiopathology ; Glucose Clamp Technique ; Glucose Tolerance Test ; Hepatitis B ; Hepatitis C ; Hepatitis, Viral, Human - metabolism ; Hepatitis, Viral, Human - physiopathology ; Humans ; hyperinsulinemic euglycemic clamp combined with oral glucose load ; indirect calorimetry ; Insulin Resistance - physiology ; Liver - physiopathology ; liver cirrhosis ; Liver Cirrhosis - metabolism ; Liver Cirrhosis - physiopathology ; Liver Cirrhosis, Alcoholic - metabolism ; Liver Cirrhosis, Alcoholic - physiopathology ; Middle Aged ; nutritional assessment</subject><ispartof>The Journal of Medical Investigation, 2014, Vol.61(1.2), pp.180-189</ispartof><rights>2014 by The University of Tokushima Faculty of Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-650c1dd9e8acbd9d145288604ce91e373ac49e1d91259add51e060cd785e80993</citedby><cites>FETCH-LOGICAL-c610t-650c1dd9e8acbd9d145288604ce91e373ac49e1d91259add51e060cd785e80993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24705764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taguchi, Kayo</creatorcontrib><creatorcontrib>Yamanaka-Okumura, Hisami</creatorcontrib><creatorcontrib>Mizuno, Akira</creatorcontrib><creatorcontrib>Nakamura, Taki</creatorcontrib><creatorcontrib>Shimada, Mitsuo</creatorcontrib><creatorcontrib>Doi, Toshio</creatorcontrib><creatorcontrib>Takeda, Eiji</creatorcontrib><title>Insulin resistance as early sign of hepatic dysfunction in liver cirrhosis</title><title>The Journal of Medical Investigation</title><addtitle>J. Med. Invest.</addtitle><description>Glucose intolerance characterized by postprandial hyperglycemia and hyperinsulinemia is commonly seen in patients with liver cirrhosis (LC). The aim of this study is to clarify the relation between glucose intolerance and disorder of liver function in patients with LC. The 75 g oral glucose tolerance test (75 g OGTT) and the hyperinsulinemic euglycemic clamp combined with 0.2 g/kg oral glucose load (HECGL) were conducted in 61 patients with LC. Based on the results of 75 g OGTT, the 61 patients with LC were divided into groups, 21 (34.4%) patients with normal glucose tolerance (LC-NGT), 12 (19.7%) patients with impaired glucose tolerance (LC-IGT) and 28 (45.9%) patients with diabetes mellitus (LC-DM). Fasting plasma glucose (FPG) level was normal in 50 (82.0%) patients with LC. All patients with LC showed insulin resistance in both peripheral (skeletal and adipose) and hepatic tissues evaluated by HECGL, although significant correlation between the degree of glucose intolerance and the severity of hepatic dysfunction was not observed. Insulin resistance in both liver and peripheral tissues is the early sign in the patients with LC. This fact indicates that nutritional care from early stages of LC would be necessary in the patients. J. Med. Invest. 61: 180-189, February, 2014</description><subject>Aged</subject><subject>Blood Glucose - metabolism</subject><subject>Case-Control Studies</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Glucose Clamp Technique</subject><subject>Glucose Tolerance Test</subject><subject>Hepatitis B</subject><subject>Hepatitis C</subject><subject>Hepatitis, Viral, Human - metabolism</subject><subject>Hepatitis, Viral, Human - physiopathology</subject><subject>Humans</subject><subject>hyperinsulinemic euglycemic clamp combined with oral glucose load</subject><subject>indirect calorimetry</subject><subject>Insulin Resistance - physiology</subject><subject>Liver - physiopathology</subject><subject>liver cirrhosis</subject><subject>Liver Cirrhosis - metabolism</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Liver Cirrhosis, Alcoholic - metabolism</subject><subject>Liver Cirrhosis, Alcoholic - physiopathology</subject><subject>Middle Aged</subject><subject>nutritional assessment</subject><issn>1343-1420</issn><issn>1349-6867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEQhoMotlYv_gDJWdia2Wyym5NI8aNS8KLnkCazbcp2tyRbof_eaOueZmCe94V5CLkFNs1B5A-brZ9KmELFzsgYeKEyWcny_G_nGRQ5G5GrGDeMcS6EuCSjvCiZKGUxJu_zNu4b39KA0cfetBapiRRNaA40-lVLu5qucWd6b6k7xHrf2t53LU2Rxn9joNaHsO5S-Jpc1KaJeHOaE_L18vw5e8sWH6_z2dMisxJYn0nBLDinsDJ26ZSDQuRVJVlhUQHykhtbKASnIBfKOCcAmWTWlZXAiinFJ-T-2GtDF2PAWu-C35pw0MD0rxCdhGgJOglJ8N0R3u2XW3QD-m8gAY9HYJO-X-EAmJA-bnDo0vmpcrjYtQkaW_4DGNpzPw</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Taguchi, Kayo</creator><creator>Yamanaka-Okumura, Hisami</creator><creator>Mizuno, Akira</creator><creator>Nakamura, Taki</creator><creator>Shimada, Mitsuo</creator><creator>Doi, Toshio</creator><creator>Takeda, Eiji</creator><general>The University of Tokushima Faculty of Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2014</creationdate><title>Insulin resistance as early sign of hepatic dysfunction in liver cirrhosis</title><author>Taguchi, Kayo ; Yamanaka-Okumura, Hisami ; Mizuno, Akira ; Nakamura, Taki ; Shimada, Mitsuo ; Doi, Toshio ; Takeda, Eiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-650c1dd9e8acbd9d145288604ce91e373ac49e1d91259add51e060cd785e80993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Blood Glucose - metabolism</topic><topic>Case-Control Studies</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Glucose Clamp Technique</topic><topic>Glucose Tolerance Test</topic><topic>Hepatitis B</topic><topic>Hepatitis C</topic><topic>Hepatitis, Viral, Human - metabolism</topic><topic>Hepatitis, Viral, Human - physiopathology</topic><topic>Humans</topic><topic>hyperinsulinemic euglycemic clamp combined with oral glucose load</topic><topic>indirect calorimetry</topic><topic>Insulin Resistance - physiology</topic><topic>Liver - physiopathology</topic><topic>liver cirrhosis</topic><topic>Liver Cirrhosis - metabolism</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>Liver Cirrhosis, Alcoholic - metabolism</topic><topic>Liver Cirrhosis, Alcoholic - physiopathology</topic><topic>Middle Aged</topic><topic>nutritional assessment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taguchi, Kayo</creatorcontrib><creatorcontrib>Yamanaka-Okumura, Hisami</creatorcontrib><creatorcontrib>Mizuno, Akira</creatorcontrib><creatorcontrib>Nakamura, Taki</creatorcontrib><creatorcontrib>Shimada, Mitsuo</creatorcontrib><creatorcontrib>Doi, Toshio</creatorcontrib><creatorcontrib>Takeda, Eiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The Journal of Medical Investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taguchi, Kayo</au><au>Yamanaka-Okumura, Hisami</au><au>Mizuno, Akira</au><au>Nakamura, Taki</au><au>Shimada, Mitsuo</au><au>Doi, Toshio</au><au>Takeda, Eiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin resistance as early sign of hepatic dysfunction in liver cirrhosis</atitle><jtitle>The Journal of Medical Investigation</jtitle><addtitle>J. Med. Invest.</addtitle><date>2014</date><risdate>2014</risdate><volume>61</volume><issue>1.2</issue><spage>180</spage><epage>189</epage><pages>180-189</pages><issn>1343-1420</issn><eissn>1349-6867</eissn><abstract>Glucose intolerance characterized by postprandial hyperglycemia and hyperinsulinemia is commonly seen in patients with liver cirrhosis (LC). The aim of this study is to clarify the relation between glucose intolerance and disorder of liver function in patients with LC. The 75 g oral glucose tolerance test (75 g OGTT) and the hyperinsulinemic euglycemic clamp combined with 0.2 g/kg oral glucose load (HECGL) were conducted in 61 patients with LC. Based on the results of 75 g OGTT, the 61 patients with LC were divided into groups, 21 (34.4%) patients with normal glucose tolerance (LC-NGT), 12 (19.7%) patients with impaired glucose tolerance (LC-IGT) and 28 (45.9%) patients with diabetes mellitus (LC-DM). Fasting plasma glucose (FPG) level was normal in 50 (82.0%) patients with LC. All patients with LC showed insulin resistance in both peripheral (skeletal and adipose) and hepatic tissues evaluated by HECGL, although significant correlation between the degree of glucose intolerance and the severity of hepatic dysfunction was not observed. Insulin resistance in both liver and peripheral tissues is the early sign in the patients with LC. This fact indicates that nutritional care from early stages of LC would be necessary in the patients. J. Med. Invest. 61: 180-189, February, 2014</abstract><cop>Japan</cop><pub>The University of Tokushima Faculty of Medicine</pub><pmid>24705764</pmid><doi>10.2152/jmi.61.180</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Blood Glucose - metabolism Case-Control Studies diabetes mellitus Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Glucose Clamp Technique Glucose Tolerance Test Hepatitis B Hepatitis C Hepatitis, Viral, Human - metabolism Hepatitis, Viral, Human - physiopathology Humans hyperinsulinemic euglycemic clamp combined with oral glucose load indirect calorimetry Insulin Resistance - physiology Liver - physiopathology liver cirrhosis Liver Cirrhosis - metabolism Liver Cirrhosis - physiopathology Liver Cirrhosis, Alcoholic - metabolism Liver Cirrhosis, Alcoholic - physiopathology Middle Aged nutritional assessment |
| title | Insulin resistance as early sign of hepatic dysfunction in liver cirrhosis |
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