Protective effects of glycoglycerolipids extracted from spinach on 5-fluorouracil induced intestinal mucosal injury

Glycoglycerolipids are mostly found in plants, however the beneficial effects of the glycoglycerolipids on mammalian body have not been understood. In this study, we investigated the effects of glycolipid extracts from spinach, which highly contained glycoglycerolipids, on mucosal injury induced by...

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Veröffentlicht in:	The Journal of Medical Investigation 2010, Vol.57(3,4), pp.314-320
Hauptverfasser:	Shiota, Asuka, Hada, Takahiko, Baba, Tomoko, Sato, Minako, Yamanaka-Okumura, Hisami, Yamamoto, Hironori, Taketani, Yutaka, Takeda, Eiji
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Alkaline Phosphatase - metabolism Animals Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antioxidants - isolation & purification Antioxidants - pharmacology Caco-2 Cells Cytokines - genetics Fluorouracil - antagonists & inhibitors Fluorouracil - toxicity Galactolipids - pharmacology Glycine max - chemistry glycoglycerolipid Glycolipids - isolation & purification Glycolipids - pharmacology Humans Intestinal Mucosa - drug effects Intestinal Mucosa - injuries Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Male mucositis Mucositis - chemically induced Mucositis - prevention & control oxidative stress Plant Extracts - chemistry Plant Extracts - pharmacology Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Spinacia oleracea - chemistry
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